Alarming Problem Research Articles

Exploration of catalytic activities of Caesalpinia bonduc (L.) Roxb. ash on green-oxidation of small organic substrates: an effective way to reduce the use of harsh chemicals

In this modern era, large-scale industrial use of harsh chemicals is an alarming problem as it can cause serious environmental damage. Among industrial pollutants, harsh chemical oxidizing agents are one of the leading chemicals that can cause severe environmental threats. These harmful harsh chemicals are practically omnipresent in industries and are used to oxidize numerous small organic substrates. Replacement of these harsh chemicals with some plant-based products might be helpful to safeguard our environmental damage. In this study, Caesalpinia bonduc (L.) Roxb. ash is used as a catalyst to activate aerial oxygen for promoting the oxidation of 3,5-di-tert-butylcatechol (3,5-DTBC) and o-aminophenol (OAPH) like small organic substrates. Detailed kinetic studies for these catalytic oxidation reactions have been performed spectrophotometrically, which confirms that catalytic reactions follow Michaelis–Menten kinetics. Several enzyme-kinetics plots such as the Michaelis–Menten plot, Lineweaver–Burk plot, Hanes–Woolf plot, and Eadie–Hofstee plot have been used to determine the maximum rate achieved by the reaction (Vmax) and Michaelis constant (KM) like kinetic parameters. The average values of Vmax and KM for catalytic oxidation of 3,5-DTBC are (8.6669 ± 0.6519) × 10–5 M S−1 and (21.4289 ± 0.4741) × 10–4 M, respectively. Similarly, the average values of Vmax and KM for catalytic oxidation of OAPH are (2.1781 ± 0.2071) × 10–5 M S−1 and (20.1062 ± 1.2690) × 10–3 M, respectively. The mineral composition of Caesalpinia bonduc (L.) Roxb. ash has also been evaluated by using inductively coupled plasma optical emission spectroscopy (ICP-OES).Graphical

The prevalence of Hemophilia A in males in Africa: evidence from a systematic review and meta-analysis

BackgroundHemophilia A (HA) is an X-linked recessive bleeding disorder characterized by reduced or absent coagulation factor (F) VIII activity. The empirical evidence on the prevalence of HA in Africa has reported inconsistent findings and seems to present such a wide range of prevalence that it is hard to swiftly ascertain its average extent. Hence, this review aimed to pool the results of primary studies reporting the prevalence of HA into a single estimate in the region.MethodsWe followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles published in EMBASE, PubMed, Web of Science, SCOPUS, Science Direct, and Cochrane Library databases were searched. Observational studies revealing the prevalence of HA in Africa between 2010 and 2023 were incorporated. We assessed the quality of each study using the Newcastle-Ottawa quality assessment tool. The prevalence of HA was estimated as the cases (the sample size) per 100,000 population multiplied by 1000. To produce the pooled estimate, Der Simonian random-effects models were computed with Metaprop on the STATA command. The studies’ heterogeneity was assessed using the I-squared (I2) value test and the Galbraith plot. A funnel plot was conducted to evaluate publication bias.ResultsOf the 337 studies accessed, we included 15 that fulfilled the eligibility criteria. The random-effect model meta-analysis demonstrated the overall pooled prevalence of HA was 6.82 cases per 100,000 persons (95% confidence interval: 5.16, 8.48) with heterogeneity (I2 = 0.00%, p < 0.001).ConclusionsThis systematic review and meta-analysis revealed that HA is an alarming problem that may pose a future threat to public health in Africa. Given the detrimental effects of the disease on health and the complications involved, we recommended that African regions increase patient access to factor VIII medication, improve carrier detection rates, and take the initiative toward the development and access to gene therapy.

A Review On: Role of Pearl Millet Derived Gluten Free Product and Its Benefit in Treating Iron Deficiency Anaemia in Celiac Patients

Hidden hunger is a global issue and is coming up as a alarming problem for mankind. At the same time world’s most popular countries data showed the occurrence of Celiac Disease, mostly popular in India, Brazil, Russia also in US. 5-8 million people of India is expected to have celiac disease which is not a number can be ignored. The Strict Gluten Free Diet (GFD) is the only therapy intended for celiac patients, as a result most of the patient suffers from Iron Deficiency Anemia which is one of the most reported additional intestinal manifestations of celiac disease. Today’s market lacks the proper gluten free diet products. Most of them are either too costly or not nutrient dense. Millets being a Nutri cereal and old-style staple food of the dry land areas of the world can work as wonder in treating this problem. Among millets, Pearl millet is famous and important grain in the dry and semitropical areas of many developing countries. Proper fortification, enrichment and introducing millets in the plate of celiac patients are showing beneficial result in improving their health status. Our present study will review the part of pearl millet derived product and their efficacy, in treating iron deficiency anemia in celiac patients.

DETECTION OF FAKE NEWS ON TWITTER USING MACHINE LEARNING: AN XGBOOST-BASED APPROACH WITH SENTIMENT AND SOURCE CHARACTERISTIC ANALYSIS

The spread of fake news on social media platforms is becoming an increasingly alarming problem with fake news becoming more deceptive and harder to detect. Twitter, in particular, poses a significant threat as fake news spreads faster than real news on the platform, enhancing misinformation and leading to serious consequences.This project presents a novel machine learning-based approach for detecting fake news tweets on Twitter using the TruthSeeker 2023 dataset from the University of New Brunswick. As the largest ground truth dataset for fake news detection on social media, it contains over 130,000 crowdsourced tweets, enabling the creation of a broader and more applicable model for real-world scenarios. The algorithm employed in this study leverages the properties of gradient-boosted decision tree models (XGBoost) to develop a novel method for classifying fake and real news tweets. The proposed model preprocesses the data by extracting additional features for each tweet, such as detailed sentiment analysis of both the tweet and the related news statement, as well as features pertaining to the author. These features are added to the tweets feature vector. The enhanced feature vectors are then fed into an XGBoost model with tuned hyperparameters determined through a grid search algorithm to perform binary classification. The additional extracted features increase the robustness of the model by highlighting key differentiating factors between real and fake tweets. The results of this study demonstrate the effectiveness of the proposed algorithm, achieving an accuracy of 0.9335 on over 13,000 unseen tweets.

Homoeopathic dilution of Berberis vulgaris and Urinary calculi: A Case Series

Introduction- Consequent upon the changing lifestyle the incidence of urinary calculus is emerging as one of the alarming problems around the globe. Apart from modern management, homoeopathy provides an alternative and effective means for its management. In this case series Six successfully treated cases of urinary calculi are presented which shows how potentized homoeopathic medicine Berberis vulgaris (Berb-v) is effective in expelling and mitigating urinary calculi. Case summary- After proper case taking Berb-v in diluted and potentised form was prescribed specifically in pre-diagnosed six cases. They were followed up for varied periods of time at 15 to 20 days intervals after first enrolment. Calculi were expelled with diminution of symptoms. However, more and more randomized control trials and other basic researches are needed to evaluate and explore the effectiveness of Berb-v in urinary calculi.

“Knowledge, attitude and reporting practices of ventilator-related errors among nursing professionals"

BackgroundVentilator-related errors (VREs) pose a critical concern for patient safety, necessitating a thorough understanding and mitigation strategies within healthcare settings. This study delves into the prevalence of VREs, while examining the nurse's knowledge of VREs and their reporting attitudes, and practices. Study designCross sectional analytical study. MethodsA cross-sectional study was conducted on 129 nurses working in the Intensive Care Unit (ICU) of a major tertiary care hospital located in the southern part of India. The study involved the administration of a Knowledge, Attitude, and Practice (KAP) survey questionnaire. ResultsThe findings demonstrate a deficiency in the comprehension of VREs among ICU nurses, which subsequently affects their attitudes and reporting practices. Only a small percentage of nurses possess good knowledge (13.2 %), attitude (7 %), and reporting practices (5.4 %). Many nurses identified issues with ventilator performance, including component failure (17 %), design issues (14 %), and alarm problems (14 %). They also reported battery-related problems (9 %), lack of awareness of the instruction manual (7 %), software challenges (6 %), and wear and tear (6 %). A significant association between VRE knowledge and staff experience (p < 0.05) and attitude (P < 0.001) was found. Reporting practices are influenced by staff attitudes (moderate, P < 0.001; good, P < 0.001). ConclusionThis study highlights the significant impact of VRE on patient safety, emphasizing the urgent need for comprehensive understanding and effective preventative measures in healthcare settings.

Journalists in a circular economy: Stakeholders’ engagement in the media discourse on single-use plastics during the COVID-19 pandemic

The world faces an alarming plastic waste problem. The volume of plastic waste is rapidly and continuously increasing, mainly due to the single-use plastics overconsumption, whereas its recycling and utilization leave much to be desired. Despite the negative effects of plastic on the environment and public health, the COVID-19 outbreak shifted the public attention away from the environmental issues, potentially giving space for extended lobbyism by interest groups and industry to delay or even prevent legislation to combat plastic pollution.Our study aims to understand how the media discourse on single-use plastic (SUP) in particular, evolves in the course of the pandemic. How it vary across EU Member States? For this purpose, we specifically analyse plastic-related articles in major prestigious daily newspapers published between June 2019 and June 2021 in four EU Member States: Germany, France, Italy, and Poland, as countries with different levels of sustainable transition to form a representative model of an European context. Additionally, between November 2022 and January 2023, we conducted a series of interviews via Google Meet, with journalists who agreed to be asked on the plastic issues they upraised.Our analysis initially covered 1076 articles, out of which 198 articles were rejected due to non-compliance with the subject or repetition, leaving 878 articles forming the database for eventual analysis. Specifically, we outline a key impact of the COVID-19 pandemic followed by a clear evolution on the number of plastic-related articles, on related stakeholder engagement, and the focus on specific SUP items. Moreover, we address a research gap - presenting a media portrait of different types of SUP in more details and highlighting the significance based on several culturally and linguistically very different countries within a single supranational state (EU).A clear trend reversal towards an informed knowledge circulation across the circular economy model of single-use plastics is ultimately essential to develop sustainable solutions to reject the disposable culture, stop the waste of natural resources, and reduce the consumption of oil or gas for plastic production and thus protect the climate.

Knowledge, attitudes, and practices of dentists about patients with HIV/AIDS: a descriptive study at the dentists

ABSTRACTIntroduction: Human Immunodeficiency Virus (HIV) is still an alarming global public health problem. Individuals infected with HIV can develop Acquired Immune Deficiency Syndrome (AIDS) when the infection reaches an advanced stage. Dentists are a group at high risk of contracting HIV/AIDS. Therefore, dentists must have good knowledge, attitudes, and practices towards HIV/AIDS patients. The purpose of this study was to determine the knowledge level, attitudes, and practices of dentists about patients with HIV/AIDS. Method: This type of research was descriptive with a cross-sectional design and was carried out directly at dentists' private practices or clinics in Medan. A total of 1319 dentists in Medan included 299 dentists during 2024 using a simple random sampling method. Data collection regarding knowledge, attitudes, and practices towards patients with HIV/AIDS from dentists in Medan was carried out using questionnaires. Results: The majority of respondents had a better level of knowledge regarding HIV/AIDS at 51.2%, followed by 44.5% of respondents having a moderate level of knowledge and only 4.3% of respondents having a poor level of knowledge. The majority of respondents had a neutral attitude, namely 58.9% and 34.8% of respondents had a negative attitude, and only 6.4% of respondents had a positive attitude towards patients with HIV/AIDS. The majority of respondents had a good level of practice at 49.2%, 44.1% of respondents had a moderate level of practice, and only 6.7% of respondents had a poor level of practice towards patients with HIV/AIDS. Conclusion: Satisfactory level of knowledge, neutral attitudes, and good practices regarding patients with HIV/AIDS. To maintain a good level of knowledge and practice and establish positive attitudes towards patients with HIV/AIDS, there is a need for improvement in education and post-graduate courses, refresher courses, seminars, and training about HIV/AIDS.KEYWORDSknowledge, attitudes, practices, HIV/AIDS, dentists

High efficiency of treated-phengite clay by sodium hydroxide for the Congo red dye adsorption: Optimization, cost estimation, and mechanism study

Wastewater textile dye treatment is a challenge that requires the development of eco-friendly technology to avoid the alarming problems associated with water scarcity and health-environment. This study investigated the potential of phengite clay as naturally low-cost abundant clay from Tamgroute, Morocco (TMG) that was activated with a 0.1 M NaOH base (TMGB) after calcination at 850 °C for 3 h (TMGC) before its application in the Congo red (CR) anionic dye from the aqueous solution. The effect of various key operational parameters: adsorbent dose, contact time, dye concentration, pH, temperature, and the effect of salts, was studied by a series of adsorption experiments in a batch system, which affected the adsorption performance of TMG, TMGC, and TMGB for CR dye removal. In addition, the properties of adsorption kinetics, isotherms, and thermodynamics were also studied. Experimental results showed that optimal adsorption occurred at an acidic pH. At a CR concentration of 100 mg L−1, equilibrium elimination rates were 68%, 38%, and 92% for TMG, TMGC, and TMGB, respectively. The adsorption process is rapid, follows pseudo-second-order kinetics, and is best described by a Temkin and Langmuir isotherm. The thermodynamic parameters indicated that the adsorption of CR onto TMGB is endothermic and spontaneous. The experimental values of CR adsorption on TMGB are consistent with the predictions of the response surface methodology. These led to a maximum removal rate of 99.97% under the following conditions: pH = 2, TMGB dose of 7 g L−1, and CR concentration of 50 mg L−1. The adsorbent TMGB's relatively low preparation cost of around $2.629 g-1 and its ability to regenerate in more than 6 thermal calcination cycles with a CR removal rate of around 56.98%, stimulate its use for textile effluent treatment on a pilot industrial scale.

Descriptive study of the oral health status of disadvantaged mexican populations in relation to their adherence to the mediterranean diet.

Obesity in Mexico is an alarming problem that has been increasing in recent decades. Dietary factors make this pathology more common at younger ages and closely related to oral health. This study attempts to investigate the association between the oral health status of a Mexican population in the state of Yucatan and their dietary habits. This study explores the relationship between oral health-related quality of life and adherence to the Mediterranean diet in a disadvantaged population in the state of Yucatan, Mexico. The research was conducted in July 2023 in Merida, Yucatan (Mexico). The sample consisted of 109 individuals aged between 4 and 72 years old. Data analysis focused on factors such as body mass index (BMI), oral health-related quality of life, and adherence to the Mediterranean diet. A notable presence of caries is observed in individuals with low adherence to the Mediterranean diet (Correlation coefficient 0.040, p=0.682). This underscores the potential interaction between oral health, obesity, and dietary habits. The mean Oral Health-Related Quality of Life (OHIP-14Sp) score was 13.19 ±13.57, median 8.00. This research adds to the increasing evidence that highlights the significance of a balanced diet in enhancing the oral quality of life for people. More research is necessary to explore preventive measures and treatment to raise awareness about oral health within the community.

Nutrition Intervention in reducing gestational Diabetes Mellitus

To review literature about Nutrition Intervention in reducing Gestational Diabetes Mellitus (GDM). We conducted a literature search for published articles on “Nutrition Therapy in reducing Gestational Diabetes” “Nutrition therapy” Gestational diabetes” “diabetes” and “Gestation” as keywords search in the Sothern Medical University Library Electronic resources (E-resources), PubMed, ScienceDirect, Web of Science and other databases including Google Scholar. A search strategy was developed for each database with no restriction on language and publication status, 75% of the papers used in this study were published in the last 5 years. Several studies have established that gestational diabetes mellitus (GDM) is an alarming health problem worldwide and is one of the most common complications of nutrition intervention in addressing GDM in pregnant women and one of the causes of the T2DM in the world. During pregnancy, it is most likely to be a critical moment for appropriate therapy and activities aimed at reducing the incidence of T2DM.

Antimicrobial Resistance in Livestock: A Serious Threat to Public Health.

Antimicrobial resistance represents an alarming public health problem; its importance is related to the significant clinical implications (increased morbidity, mortality, disease duration, development of comorbidities, and epidemics), as well as its economic effects on the healthcare sector. In fact, therapeutic options are severely limited by the advent and spread of germs resistant to many antibiotics. The situation worldwide is worrying, especially in light of the prevalence of Gram-negative bacteria-Klebsiella pneumoniae and Acinetobacter baumannii-which are frequently isolated in hospital environments and, more specifically, in intensive care units. The problem is compounded by the ineffective treatment of infections by patients who often self-prescribe therapy. Resistant bacteria also show resistance to the latest generation antibiotics, such as carbapenems. In fact, superbacteria, grouped under the acronym extended-spectrum betalactamase (ESBL), are becoming common. Antibiotic resistance is also found in the livestock sector, with serious repercussions on animal production. In general, this phenomenon affects all members of the biosphere and can only be addressed by adopting a holistic "One Health" approach. In this literature overview, a stock is taken of what has been learned about antibiotic resistance, and suggestions are proposed to stem its advance.

Bridging the gap: understanding out-of-school children in Pakistan

ABSTRACT Education plays a central role in promoting social inclusion, respect and dignity and therefore contributes significantly to economic and social progress. The accessibility and quality of education are directly related to the development of any country. Therefore, ensuring equal access to quality education is crucial for sustainable economic growth, especially in developing countries. UNICEF’s ranking of Pakistan as the country with the second highest number of school dropouts in the world stimulated this study to address the alarming problem of large numbers of out-of-school children in marginalized communities such as Pakistan. The study aims to examine the multiple factors that stimulate dropout rates or out of school, including socioeconomic status, geographical location, child-related characteristics, child labor, skills and attitudes. Using data from MICS Wave 6 in Pakistan, this study proposes recommendations for educators and policymakers aimed at promoting equal educational opportunity and inclusive growth around the world.

Crithmum maritimum Extract Restores Lipid Homeostasis and Metabolic Profile of Liver Cancer Cells to a Normal Phenotype

Hepatocellular carcinoma (HCC) is an alarming epidemiological clinical problem worldwide. Pharmacological approaches currently available do not provide adequate responses due to poor effectiveness, high toxicity, and serious side effects. Our previous studies have shown that the wild edible plant Crithmum maritimum L. inhibits the growth of liver cancer cells and promotes liver cell differentiation by reducing lactic acid fermentation (Warburg effect). Here, we aimed to further characterise the effects of C. maritimum on lipid metabolism and markers of cellular metabolic health, such as AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1), and Sirtuin 3 (SIRT3), as well as the insulin signalling pathway. To better mimic the biological spectrum of HCC, we employed four HCC cell lines with different degrees of tumorigenicity and lactic acid fermentation/Warburg phenotype. Lipid accumulation was assessed by Oil Red O (ORO) staining, while gene expression was measured by real-time quantitative PCR (RT-qPCR). The activation of AMPK and insulin signalling pathways was determined by Western blotting. Results indicate that C. maritimum prevents lipid accumulation, downregulates lipid and cholesterol biosynthesis, and modulates markers of metabolic health, such as AMPK, SIRT1 and SIRT3. This modulation is different amongst HCC cell lines, revealing an important functional versatility of C. maritimum. Taken together, our findings corroborate the importance of C. maritimum as a valuable nutraceutical, reinforcing its role for the improvement of metabolic health.

Global Landscape of the Attack of Predatory Journals in Oncology.

Open-access publishing expanded opportunities to give visibility to research results but was accompanied by the proliferation of predatory journals (PJos) that offer expedited publishing but potentially compromise the integrity of research and peer review. To our knowledge, to date, there is no comprehensive global study on the impact of PJos in the field of oncology. A 29 question-based cross-sectional survey was developed to explore knowledge and practices of predatory publishing and analyzed using descriptive statistics and binary logistic regression. Four hundred and twenty-six complete responses to the survey were reported. Almost half of the responders reported feeling pressure to publish from supervisors, institutions, and funding and regulatory agencies. The majority of authors were contacted by PJos through email solicitations (67.8%), with fewer using social networks (31%). In total, 13.4% of the responders confirmed past publications on PJo, convinced by fast editorial decision time, low article-processing charges, limited peer review, and for the promise of academic boost in short time. Over half of the participants were not aware of PJo detection tools. We developed a multivariable model to understand the determinants to publish in PJos, showing a significant correlation of practicing oncology in low- and middle-income countries (LMICs) and predatory publishing (odds ratio [OR], 2.02 [95% CI, 1.01 to 4.03]; P = .04). Having previous experience in academic publishing was not protective (OR, 3.81 [95% CI, 1.06 to 13.62]; P = .03). Suggestions for interventions included educational workshops, increasing awareness through social networks, enhanced research funding in LMICs, surveillance by supervisors, and implementation of institutional actions against responsible parties. The prevalence of predatory publishing poses an alarming problem in the field of oncology, globally. Our survey identified actionable risk factors that may contribute to vulnerability to PJos and inform guidance to enhance research capacity broadly.

Data-Driven-Based Intelligent Alarm Method of Ultra-Supercritical Thermal Power Units

In order to ensure the safe operation of the ultra-supercritical thermal power units (USCTPUs), this paper proposes an intelligent alarm method to enhance the performance of the alarm system. Firstly, addressing the issues of slow response and high missed alarm rate (MAR) in traditional alarm systems, a threshold optimization method is proposed by integrating kernel density estimation (KDE) and convolution optimization algorithm (COA). Based on the traditional approach, the expected detection delay (EDD) indicator is introduced to better evaluate the response speed of the alarm system. By considering the false alarm rate (FAR), and EDD, a threshold optimization objective function is constructed, and the COA is employed to obtain the optimal alarm threshold. Secondly, to address the problem of excessive nuisance alarms, this paper reduces the number of nuisance alarms by introducing an adaptive delay factor into the existing system. Finally, simulation results demonstrate that the proposed method significantly reduces the MAR and EDD, improves the response speed and performance of the alarm system, and effectively reduces the number of nuisance alarms, thereby enhancing the quality of the alarms.

Mechanical design of an upper limb robotic rehabilitation system

Physical diseases have become an alarming social problem worldwide. Several conditions related to limb mobility are more frequent due to a high level of demand in the repetitive execution of activities. Assistive technologies have been proposed to improve the experience of physical rehabilitation. This paper presents a framework with the mechanical design criteria for an upper limb assistive robotic system. We define the design specifications and construction characteristics of an assistive system. As a result, a 7-degree-of-freedom system for upper limb physical rehabilitation is designed with a novel characteristic of arm-switching configuration for the treatment of both arms.

Epidemiological investigation of dengue fever outbreak and its socioeconomic determinants in Banadir region, Somalia

BackgroundDengue has become an alarming global problem and is endemic in many countries, particularly in tropical and subtropical countries. The aim of this study was to investigate dengue fever outbreak in Banadir Region, Somalia, to understand the risk factors (time, place, personal characteristics).MethodsA descriptive cross-sectional study was undertaken to determine the levels of circulating anti-dengue virus antibodies and DENV NS1 antigen among Banadir Region residents, while a questionnaire survey was conducted to understand the clinical and demographic characteristics of the patients.ResultsA total of 735 febrile patients were studied, with 55.6% men and 44.3% women. The majority of the participants were children aged 14 years and younger. Among them, 10.8% tested positive for IgM antibodies against dengue virus (DENV), while the prevalence of DENV NS1 antigen was 11.8%. Fever and myalgia were the most common symptoms observed in the DENV-positive patients.ConclusionsA dengue fever outbreak has been confirmed in Banadir region, Somalia. This study provides information on the most affected districts and identifies risk factors contributing to DF outbreaks. The study recommends improving outbreak readiness and response, particularly in surveillance and laboratory diagnostics, by fostering intersectoral collaboration and establishing regulatory frameworks for financial and operational participation.

An urgent call to address work-related psychosocial hazards and improve worker well-being.

Work-related psychosocial hazards are on the verge of surpassing many other occupational hazards in their contribution to ill-health, injury, disability, direct and indirect costs, and impact on business and national productivity. The risks associated with exposure to psychosocial hazards at work are compounded by the increasing background prevalence of mental health disorders in the working-age population. The extensive and cumulative impacts of these exposures represent an alarming public health problem that merits immediate, increased attention. In this paper, we review the linkage between work-related psychosocial hazards and adverse effects, their economic burden, and interventions to prevent and control these hazards. We identify six crucial societal actions: (1) increase awareness of this critical issue through a comprehensive public campaign; (2) increase etiologic, intervention, and implementation research; (3) initiate or augment surveillance efforts; (4) increase translation of research findings into guidance for employers and workers; (5) increase the number and diversity of professionals skilled in preventing and addressing psychosocial hazards; and (6) develop a national regulatory or consensus standard to prevent and control work-related psychosocial hazards.

Multidrug-Resistant Bacterial Infections in Pediatric Patients Hospitalized at King Abdulaziz University Hospital, Jeddah, Western Saudi Arabia.

Multidrug-resistant bacterial infections (MDRIs) constitute a major global threat due to increased patient morbidity/mortality and hospital stay/healthcare costs. A few studies from KSA, including our locality, addressed antimicrobial resistance in pediatric patients. This study was performed to recognize the incidence and clinical/microbiologic features of MDRIs in hospitalized pediatric patients. A retrospective cross-sectional study included pediatric patients < 18 years, admitted to King Abdulaziz University Hospital, between October 2021 and November 2022, with confirmed positive cultures of bacteria isolated from blood/body fluids. Patients' medical files provided the required data. MDR organisms (MDROs) were identified in 12.8% of the total cultures. The incidence of MDRIs was relatively high, as it was detected in 42% of patients and in 54.3% of positive bacterial cultures especially among critically ill patients admitted to the NICU and PICU. Pneumonia/ventilator-associated pneumonia was the main type of infection in 37.8% of patients with MDROs. Klebsiella pneumoniae was the most common significantly isolated MDRO in 39.5% of MDR cultures. Interestingly, a low weight for (no need for their as terminology weight for age is standard and well-known) was the only significant risk factor associated with MDROs (p = 0.02). Mortality was significantly higher (p = 0.001) in patients with MDROs (32.4%) than in patients without MDROs (3.9%). Patients who died including 85.7% of patients with MDROs had significantly longer durations of admission, more cultures, and utilized a larger number of antibiotics than the surviving patients (p = 0.02, p = 0.01, p = 0.04, respectively). This study provided a comprehensive update on the seriously alarming problem of MDROs, and its impacts on pediatric patients. The detected findings are crucial and are a helpful guide to decid for implementing effective strategies to mitigate MDROs.