Initiation experiment of Pentaerythritol Tetranitrate (PETN) and Hexanitrostilbene IV(HNS-IV) explosives by laser driven flyer plate is conducted. By using an optimum selection of 5μm Al flyer and φ0.5×0.3 metal barrel, the explosive samples of about 1μm mean grain size and 90% theoretical maximum density(TMD) in a metal case are detonated successfully. The PETN has a much lower critical firing laser energy than HNS-IV, which is in accordance with the electrical slapper exploding practices. The much lower critical firing laser energy of the explosives makes it possible for safe transmission of laser by a fiber optic line with the core diameter no more than 600μm, and in turn makes it possible for the use of optical detonation technique in multipoint synchronous initiation of warheads.