Digital Image Correlation (DIC) is an optical measurement technique that can easily be adapted for high magnification applications. These high magnifications involve competing phenomena which must be balanced to produce the highest quality measurements. When out-of-plane displacements cause the specimen under investigation to move out of the depth of field, poor focus negatively affects the measurement. As a result, it is often recommended to reduce aperture size to improve the depth of field. However, smaller aperture sizes can also cause poor focus as the diffraction limit of light causes larger Airy disks, particularly at longer working distances. This work investigates the competing effects of both depth of field and Airy disk size in three test cases: higher magnification and shorter working distance, lower magnification and shorter working distance, and lower magnification and longer working distance. Different aperture sizes are found to change which effect dominates, and a recommendation for selecting the aperture setting to minimize measurement error from both phenomena is made.