Anatomical airways parameters, such as length, diameter and angles, have a strong effect on the flow dynamics. Aiming to explore the effect of variations of the bifurcation angle (BA) and carina rounding radius (CRR) of lower human airways on respiratory processes, numerical simulations of airflow during inhalation and exhalation were performed using synthetic bifurcation models. Geometries for the airways models were parameterized based on a set of different BA’s and several CRR’s. A range of Reynolds numbers (Re), relevant to the human breathing process, were selected to analyze airflow behavior. The numerical results showed a significant influence of BA and the CRR on the development of the airflow within the airways, and, therefore, affecting the following relevant features of the flow: the deformation of velocity profiles, alterations of pressure drop, flow patterns, and, finally, enhancement or attenuation of wall shear stresses (WSS) appearing during the regular respiratory process. The numerical results showed that increases in the bifurcation angle value were accompanied by pressure increases of about 20%, especially in the regions close to the bifurcation. Similarly, increases in the BA value led to a reduction in peak shear stresses of up to 70%. For the ranges of angles and radii explored, an increase in pressure of about 20% and a reduction in wall shear stress of more than 400% were obtained by increasing the carina rounding radius. Analysis of the coherent structures and secondary flow patterns also revealed a direct relationship between the location of the vortical structures, the local maxima of the velocity profiles and the local vorticity minima. This relationship was observed for all branches analyzed, for both the inhalation and exhalation processes of the respiratory cycle.
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