Based on the current terminal airspace structure, a method for scheduling aircraft arrival and departure that integrates trajectory optimization, conflict detection and multi-objective optimization is proposed to help implement continuous climb and descent operations in busy terminal airspace. First, based on the multi-stage optimal control theory, the Gaussian pseudo-spectral method is used to propose a vertical profile optimization method for continuous climb and descent operations, and the trajectory optimization of continuous climb and descent operations based on the cost index is realized. Secondly, according to the wake turbulence interval and release interval used by the runway, and the horizontal and vertical intervals of air operations, the Mahalanobis distance is used to establish an aircraft conflict detection model. Then, considering the demands of air traffic control, airlines, airports and other operating units, a multi-objective scheduling model and method for aircraft arrival and departure that can achieve the optimization results are proposed. Finally, two sets of arrival and departure data at Guangzhou Baiyun Airport during busy periods are selected, multiple interval parameters are set, alternative paths are introduced, and case analysis and comparative studies are carried out. The results show that during the busy period dominated by departures, the terminal airspace of Guangzhou Baiyun Airport can achieve continuous climb and descent operations during busy periods; during the busy period dominated by arrivals, two aircraft could not be dispatched. The introduction of alternative paths can reduce the number of aircraft that cannot be dispatched.