The objective of this work is the characterization and the assessment of the damage in CFRP composite laminates with different stacking sequences subjected to low velocity impact and flexural loading. Charpy impact test and three-point bending test were used in order to obtained the impact response and flexural behavior of different laminates. An experimental test series was carried out to determine impact energy absorption, flexural strength and stiffness and failure mechanisms of composite laminates made from M21E/IMA, an unidirectional prepreg used in Airbus A350 XWB primary structures. It is important to note that both elastic moduli and strength in the principal material directions are different under tension and compression. The flexural modulus is expected to have an intermediate value between the tensile and compression moduli. We analyze the effect of this type of multimodulus materials [1–3] in order to evaluate the influence of the geometry of the specimen on the failure modes (shear or flexural failure modes) observed in the three-point bending test and compare the results with tensile and compression behavior.Two main lay-up configurations have been analyzed: Unidirectional laminates [0]12,[90]12,[45]12 and multidirectional laminates (cross-ply [0/90]3s, angle-ply [±45]3s and quasi-isotropic laminates [0/90/(±45)2]s). Unidirectional laminates are rarely used in structural components but help to assess the different types of damage (splitting, matrix cracking, delamination) and response of the specimens under low-velocity impact and flexural loading. They are usually combined with plies of varying orientation in multidirectional laminates. These laminates exhibit a more complex behavior due to coupling effects and the combination of different failure modes. In this study, both impact and flexural response for the different laminates have been compared. Special attention is paid in the response of multidirectional laminates under flexural (and impact) loading. Shear effects are very important in this type of laminates. Only a limited number of experimental studies have been developed in this context [4–7]. Additionally, the failure modes observed under impact and flexural loading were correlated with fracture energy absorption and load–deflection behavior respectively for the unidirectional and multidirectional laminates.The results have shown that the effect of the stacking sequences on the impact and flexural response depicted similar trends than in the case of tensile response studied in previous works [8–11]. Furthermore, the present work has shown a distinctive behavior of [±45]3s angle-ply laminate.under impact loading due to its pseudo-ductile behavior. This laminate exhibited the best impact performance in terms of averaged absorbed energy but the flexural strength and stiffness drastically decreased compared to [0]12laminate. Finally, SEM and optical micrographs of fracture surfaces were used to gain an insight into the assessment of different type of damage of the previous laminates.