Building airtightness is crucial for reducing energy demand in the building sector and preventing moisture damage and indoor environment quality issues. Mandatory airtightness tests are now commonly performed in many countries to quantify the total envelope leakage rate of real buildings. For a more precise diagnosis, air leakages are usually identified by infrared thermography or visualized by smoke. However, a finer analysis is also needed to characterize precisely the air flow through specific leaks. Numerical models have been developed for this purpose but experimental data are necessary to validate them. In this paper, two experimental approaches are tested on simple light-wall assembly configurations to address this need: infrared thermography (IRT) and the innovative use of particle image velocimetry (PIV) with a specific experimental set-up and protocol developed. The results are compared with each other as well as with numerical simulations. Results showed that both techniques can be applied for the experimental characterization of the air inlet/outlet of a wall assembly with different advantages and drawbacks. IRT is easy to implement, non-intrusive, possible for in-situ investigations, but the correlation between the thermographs and the air dispersion at the outlet is not straight forward due to thermal inertia and heat conduction issues. PIV gives direct results on the velocity field and enables quantitative analysis of air flow rates for various configurations, with some limitations: a difficult implementation; restrictions on the possible infiltration velocity range and difficulties to visualize the flow exactly at the interface with the wall assembly.