High-resolution microclimate data is essential for capturing spatio-temporal heterogeneity of urban climate and heat health management. However, previous studies have relied on dense measurements that require significant costs for equipment, or on physical simulations demanding intensive computational loads. As a potential alternative to these methods, we propose a multimodal deep learning model to predict microclimate at a high spatial and temporal resolution based on street-level and satellite imagery. This model consists of LSTM and ResNet-18 architectures, and predicts air temperature (Tair), relative humidity (RH), wind speed (ν), and global horizontal irradiance (GHI). For our study area situated at a university campus in Singapore, we collected microclimate data, street-level and satellite imagery. We conducted extensive experiments with our collected dataset to showcase our model’s predictive capabilities and its practical use in generating high-resolution microclimate maps. Our model reported RMSE at 0.95 °C for Tair, 2.57% for RH, 0.31 m/s for ν, and 225 W/m2 for GHI. Furthermore, we observed a contribution of imagery inputs to higher accuracy by comparing models with and without such inputs. We identified hot spots at a high spatio-temporal resolution, indicating its application for issuing real-time heat alerts. Our models are released openly at the microclimate-vision GitHub repository (https://github.com/kunifujiwara/microclimate-vision).