Aim Of My Project Research Articles

Suitability analysis for wind farm constructions in Yukon area

The development of science and technology has made people's quality of life better and better, and the mature use of electricity has made people's lives more convenient and faster. However, this has also led to a drastic increase in people's use of non-renewable energy such as coal and oil. In 2021, about 4,108 billion kilowatt-hours (kWh) (or about 4.11 trillion kWh) of electricity were generated at utility-scale electricity generation facilities in the United States, about 546 million short tons (MMst) of coal were consumed. (EIA). In such situation, the exploitation and use of renewable energy becomes significantly urgent and necessary. From 2008 to 2018, global installed wind power capacity grew by an average of 17.2% per year (BP Statistical Review of World Energy 2020). On IRENA's (2019) transformation roadmap, to stay on the pathway of 1.5 °C warming, wind energy is projected to generate 35% of the total electricity demand by 2050. My study area for my research is in Yukon, it is in south part of Canada and contains 4.7 percent of total area. The aim of my project is to determine the suitability of Wind Farm Expansion and its Electric Applications Radiation for Yukon area. The method for the project is using reclassify analysis tool in order to find the suitability site for constructing the wind farms. 1. How Much of Each Energy Source Does It Take to Power Your Home. (2017, September 29). McGinley Support Services. https://www.mcginley.co.uk/news/how-much-of-eachenergy-source-does-it-taketo-power-your-home/bp254/2. CER – Provincial and Territorial Energy Profiles – Yukon. (n.d.).https://www.cerrec.gc.ca/en/data-analysis/energy-markets/provincial-territorialenergyprofiles/provincial-territorial-energy-profiles-yukon.html3. Just a moment. . . (n.d.). https://www.researchgate.net/figure/Flow-Diagram-of-aWindTurbine-System-Here-1-Wind-Turbine-Converts-wind-energy- into_fig3_307906589

Investigating NRP1 and VEGFR2 association using number and brightness.

Neuropilin-1 (NRP1) is a surface glycoprotein originally found to play a role in neuronal adhesion. It has since been discovered that NRP1 is involved in vascular development, as well as tumorigenesis. NRP1 has been previously shown to exist in a monomer-dimer equilibrium in the plasma membrane, in the presence of vascular endothelial growth factor (VEGF). With the addition of vascular endothelial growth factor receptor 2 (VEGFR2), NRP1 can also form heterodimers in the presence or absence of VEGF. The aim of my project is to further probe NRP1 homo-interactions and hetero-interactions with VEGFR2 in the presence and absence of VEGFA-165, using the number and brightness fluorescence fluctuation method (N&B). Using N&B, I hope to quantify the oligomer size of NRP1 under different conditions.

Sarah Breaden: “A Refined and Splendid Kind of Girl”

ABSTRACTIn Central Australia throughout the early 20th century, many Aboriginal women gave birth to babies who had been fathered by white men. Between 1914 and 1929, these children were removed from their families and taken to live in the burgeoning town of Alice Springs, in a collection of tin sheds referred to as “the Bungalow”. Such removal of children from their families was in line with assimilation policies being enacted across the colonised world. During my research into the Bungalow, I came across a file in the National Archives entitled “Sarah Breaden (Half Caste) Education”. Sarah was born of an Aboriginal mother and white father, on a cattle station in Central Australia, in 1907. In some ways, her story, which I went on to explore, reflects that of so many children of dual Indigenous/white heritage born in that time and place. But in other ways, Sarah's circumstances and experiences differ markedly. A key aim of my project has been to research and write a creative history of the first Bungalow in Alice Springs 1914–1929, and the context in which it was situated. This article is adapted from a chapter of that literary work.

Purification of Contaminated Air from the Spinning Mill and Transformation of Microdust as Flyash for Structural Filling

Abstract: This project describes the investigation from the co-operative spinning mill at pattarkadavu. During this process micro dust is deposited in the various filtering medias. Normally in this spinning mill they were incinerating these micro dusts and these incinerated micro dust dumped into the landfills. The aim of my project is reduction of the landfill disposal of incinerated microDust and using the waste as structural filling

Data Mining Techniques to Predict Chronic Kidney Diseases

Chronic Kidney Disease (CKD) is one of the most widespread illnesses nowadays in the world. Some statistics shows that 26 million adults in the United States have CKD and million others are at increasing risk. When condition of the kidney get worse, the wastes in the blood are formed in a high level. Data mining has been a present pattern for an accomplishing analytic outcomes. The Clinical diagnosis of CKD is based on blood and urine tests as well as removing a sample of kidney tissues for testing. By Some previous diagnosis and method of detection the kidney diseases are important to help stop the progression to kidney failure. Data mining and analytics techniques which can be used for predicting CKD by utilizing samples of patient’s data and diagnosis records done previously. The aim of my project is to anticipate CKD utilizing the classification strategy Naïve Bayes. Pre-processing the data is performed to impute any missing data and identified the variables that should be considered in the prediction models. Based on the accuracy of prediction the different predictive analytics models are assessed and compared. By presenting a decision support tool which will be used to help in the diagnosis of CKD.

Recovery and Isolation of Higher Fullerenes and Metallofullerenes Via Selective Chemical Release from Waste Materials

Moving beyond the conventional HPLC approach to isolating fullerenes and endohedrals, scientists have begun using chemical methods to selectively bind either contaminant or desired species. Recently, we introduced aminopropanol as a reagent that would selectively react with spheroidal fullerenes to form water soluble derivatives, with unreacted tubular fullerenes (Fullertubes) remaining in the organic phase. In this presentation, we address the fate of the functionalized spheroidal fullerenes. These spent reaction mixtures are typically discarded as waste material. The aim of my project is to chemically release and recover pristine fullerenes and metallofullerenes. In this presentation, I will discuss our recent progress into the recovery and isolation of new higher fullerene and endohedral species. This selective release approach permits the isolation of new carbon structures.

Review on Facial Recognition

Generally face recognition perform many operations in our daily life such as security purpose identification of people and verification purpose. The basic aim of my project is to design an effective and secure technique for authentication using face recognition that can search or recognize a human face among the thousands of persons and improve the performance of face recognition system in low light conditions and also evaluate the performance of the designed framework by comparing the performance of existing face recognition system. This study also provides a automatic system through which a given still image or video of a scene, identify one or more persons in this scene by using a stored database of facial images.

Accelerated evolution of lager yeast strains for improved flavour profiles

Fermented food and beverages have accompanied humans throughout history. Several species of microorganisms can transform raw materials into products with different and improved characteristics, for example alcoholic beverages (wine and beer) or dairy products, such as yogurt. In a world of constant change and competitiveness, brewers have to modulate and create new products to satisfy consumers. Therefore, the aim of my project is to generate lager yeast capable of producing molecules that improve the organoleptic profile of alcoholic beverages and understand the genetic and biochemical changes that increases the production of these aromatic molecules. The initial work has focused on the Ehrlich Pathway and the ester production. To produce changes in the genome, two approaches have been followed: one chemical way, using Radicicol, and one physical way, Heat Shock Thermal Stress (HSTS). Both ways inhibit Heat Shock proteins. Furthermore, this inhibition produces DNA damage, introducing Single sStrand Breaks (SSBs) and Double Strand Breaks (DSBs). The result of this inhbition is damage in the DNA and, furthermore, mutations in the DNA (aneuplidies and INDELS). After the Accelerated evolution, the evolved strains were plated on media containing amino acid analogues. These amino acid analogues select for cells with decreased feed-back inhibition of amino acid biosynthesis. Different mutant strains were generated with these two ways. These strains will be tested by different approaches, as growth curves, genome ploidy using cCGH and CHEF gel and qPCR analysis to measure the flux throughout the fermentation.

PO-169 Involvement of neurotensin and neurotrophins pathways in human colorectal cancer cells 5-fluorouracil treatment resistance

IntroductionColorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Surgical resection is the only curative treatment. Depending on disease stage, chemotherapies and targeted therapies are available. Despite considerable progress, recidive cases remain frequent. Studies lead in our laboratory on different cancer models, such as CRC, highlighted the importance of neuropeptides in cancer cells survival and progression: neurotrophines (NT) and neurotensin (NTS). NT is a family of four growth factors, BDNF, NT4/5, NT3 and NGF respectively binding a specific Tropomyosin Receptor Kinase (Trk A, B or C), tyrosin kinase receptors, with a strong affinity. NT can all bind another receptor, p75NTR, with low affinity, as well as the Sortilin, a TRK co-receptor, a NT and NTS intracellular trafficking regulator and also known as Neurotensin Receptor 3 (NTR3). Neurotensin can also bind two other receptors: NTR1 with strong affinity and 2 with low affinity; both are G protein coupled receptors. Very few is known about NT and NTS pathways in CRC cells resistance to chemotherapies, 5-Fluorouracil (5FU) being the backbone of any chemotreatments. The aim of my project is to understand if and how these pathways could be involved in 5FU CRC cell resistance and survival.Material and methodsTwo human CRC cell lines from different disease stages (WiDr, SW620) were treated with 8 µM of 5FU to obtain stably 5FU resistant cell lines. Both cell lines were also xenografted in Nude mice which were treated with 5FU. Protein expressions were assessed by western blot. Cell activation was assessed by flow cytometry. Stable knockdown cell lines (NTR3) were obtained by shRNA transfection. Exosomes were purified from culture supernatants by ultracentrifugation.Results and discussionsPreliminary results show that NTSR3 protein expression is increased after 5FU treatment both in whole cell lysates and exosomes especially in the most agressive cell line (SW620). The same results were obtained in vitro and in vivo. Moreover, 5FU treatment induces a decrease of tumour size only for the least agressive line (WiDr). Indeed, the 5FU induces a quiescence state of these cells.ConclusionIt is the first time that, in CRC, the NTSR3 seems to be overexpressed in 5FU-resistant tumour cells (from primary and advanced stages), in vitro and in vivo. This receptor could constitute a new potential therapeutic target.

Tetraspanins in zebrafish development

Introduction: Tetraspanins represent a family of integral membrane proteins involved in cell-cell interaction, including adhesion, fusion, differentiation and proliferation. These basic functions are essential for embryonic development, yet there is little research on the role of tetraspanins in this process. The aim of my project is to pilot zebrafish as a new and sensitive model for assessing tetraspanin function in vertebrate development. Background: There are approximately 50 tetraspanin genes in zebrafish, representing orthologues of most of the 33 mammalian genes. mRNA expression analysis has shown that at least 22 of these are expressed in zebrafish embryos and thus may regulate developmental processes. CD9 is a well-characterized tetraspanin and we have shown that zebrafish CD9 orthologues are present in the posterior lateral line (pLL), a sensory system comprised of hair-cell containing neuromasts. The development of the pLL coordinates proliferation, deposition and migration simultaneously and thus requires highly regulated cell interactions. Major findings: We generated CRISPR double knockouts (dKOs) of both zebrafish CD9 paralogues. The dKOs are adult viable and fertile, in contrast to mouse CD9 KO females which are sterile. Inspection of the pLL in the CD9 KOs revealed that there is measurably slower migration of the primordium and fewer hair cells in the posterior neuromasts at 10 dpf. Furthermore we observed a reduced regenerative capacity of the dKO neuromasts, and also upregulation of CD9 paralogues during bone repair. Conclusions: Our results suggest a role for CD9 in collective cell migration and hair cell development. We will analyse the organisation and migration of the primordium in more detail as well as the development and regeneration of the neuromasts and bone. This will be aided by generating fluorescent transgenic zebrafish to visualise dynamic processes involved. This offers a unique insight into the in vivo function of tetraspanins.

Ethics and the Potential Conflicts between Astrobiology, Planetary Protection, and Commercial Use of Space

A high standard of planetary protection is important for astrobiology, though the risk for contamination can never be zero. It is therefore important to find a balance. If extraterrestrial life has a moral standing in its own right, it will also affect what we have to do to protect it. The questions of how far we need to go to protect extraterrestrial life will be even more acute and complicated when the time comes to use habitable worlds for commercial purposes. There will also be conflicts between those who want to set a world aside for more research and those who want to give the green light for development. I believe it is important to be proactive in relation to these issues. The aim of my project is therefore to identify, elucidate, and if possible, suggest solutions to potential conflicts between astrobiology, planetary protection, and commercial use of space.

Anthropological Renga

I am investigating performance training as an exploratory mode of inquiry. In conjunction with this I ask how may performative enquiry together with anthropological ways of working lead to sustainable forms of academic knowledge production. The underlying aim of my project is to find ways to decolonise academic scholarship that transcend the apparent complacency that cultural critique has proffered (Escobar and Restrepo 2005). An anthropology otherwise, in resonance with Escobar and Restrepo’s manifesto, in which I am exploring a recrafting of what anthropologists make. This needs to include who they make it for, in other words who anthropologists are accountable to, as well as the expected ‘products’ of their scholarly endeavours. This paper is an afterthought on the Walking Threads and how the event can further our understanding in collaborative work.

Endothelial dysfunction, a major event in atherosclerosis: PPIs impair endothelial function through activation of PAI-1

Aim: Endothelial dysfunction is a major risk factor for cardiovascular disease(CVD) and atherosclerosis. Proton pump inhibitors(PPIs) like Esomeprazole(Nexium) are widely used drugs for the treatment of gastroesophageal reflux disease. Recently, our laboratory discovered that PPIs inhibit a key enzyme dimethylarginine dimethylaminohydrolase(DDAH), which may lead to endothelial dysfunction. In addition, our clinical databases indicate that PPI use is associated with cardiovascular risk. We believe that PPIs pose a major risk for CVD by impairing endothelial function. The aim of my project is to investigate the mechanistic basis by which PPIs increase endothelial dysfunction that may lead to development of CVDs including atherosclerosis.

Delivering electronic prescribing and medicines administration in challenging areas such as paediatrics and maternity at King’s College Hospital NHS Foundation Trust

In 2013, the government announced that all NHS organisations must be paperless by 2018. The aim of my project was to design, implement and maintain six paediatric wards, which included HDU, ICU and four maternity locations, within a short 6-month time frame. The primary process involved the