AbstractMembrane filtration processes have demonstrated remarkable effectiveness in wastewater treatment, achieving high contaminant removal and producing high-quality effluent suitable for safe reuse. Membrane technologies play a primary role in combating water scarcity and pollution challenges. However, the need for more effective strategies to mitigate membrane fouling remains a critical concern. Artificial intelligence (AI) modeling offers a promising solution by enabling accurate predictions of membrane fouling, thus supporting advanced fouling mitigation strategies.This review examines recent progress in the application of AI models, with a particular focus on artificial neural networks (ANNs), for simulating membrane fouling in wastewater treatment processes. It highlights the substantial potential of ANNs, particularly the widely studied multi-layer perceptron (MLP) and other emerging configurations, to accurately predict membrane fouling, thereby enhancing process optimization and fouling mitigation efforts. The review discusses both the potential benefits and current limitations of AI-based strategies, analyzing recent studies to offer valuable insights for designing ANNs capable of providing accurate fouling predictions. Specifically, it provides guidance on selecting appropriate model architectures, input/output variables, activation functions, and training algorithms. Finally, this review highlights the critical need to connect research findings with practical applications in full-scale wastewater treatment plants. Key steps crucial to address this challenge have been identified, emphasizing the potential of AI modeling to revolutionize process control and drive a paradigm shift toward more efficient and sustainable membrane-based wastewater treatment.