AbstractAmagmatic geothermal systems within regional‐scale orogenic faults are promising renewable resources for heat and possibly electricity production. However, their behavior needs to be better understood to improve their exploration and assessment of energy potential. To provide more insight, we report geochemical, geological, and geophysical studies from seven hot spring sites strung along a 90 km segment of the Agua Blanca Fault, which traverses a mountainous region of northern Baja California, Mexico. Our results show that topographic heads drive infiltration of meteoric water deep into basement rocks, where it is heated according to the local geothermal gradients. Long paths lead to long water residence times and high 3He/Hetotal fractions. The hot water ascends along preferentially permeable zones within the ABF, discharging at temperatures from 37°C in inland springs to 102°C on the Pacific coast. Higher discharge temperatures correlate positively with the degree of extensional fault displacement (a proxy for fault permeability). Correlations between hydraulic head gradients, residence times, and 3He/Hetotal of the thermal waters show that the hydraulic head gradient controls the length and depth of the flow paths, whereas the magnitudes and locations of the discharge sites are controlled by fault permeability. Optimal conditions at the coast allow the 120°C temperature threshold for electricity production to be reached at relatively shallow depths (<2 km), demonstrating the potential of orogenic geothermal systems not only for exploitation of hot discharging water but also for EGS exploitation of the hot rocks that surround the water upflow zones.