With the impact of climate change in recent years, the instability of precipitation and the increase of evaporation have made water resources in Shaanxi Province more and more stressed. How to maintain stable economic development while ensuring the sustainable development of agriculture within the limited water resources has become an important issue facing Shaanxi Province. This paper analyzes the temporal and spatial distribution characteristics of maize irrigation water requirement in Shaanxi Province based on meteorological data and obtains the ideal irrigation water requirement. However, considering the agricultural water scarcity issue in this region, this paper establishes different water scarcity scenarios, adopts the Jensen model to construct an objective function aimed at minimizing crop yield reduction, and solves it using a genetic algorithm to obtain the optimized maize irrigation scheduling under different water scarcity scenarios. The results analysis indicates the following: (1) The effective rainfall in Shaanxi Province from 1960 to 2019 shows a slight upward trend, while the maize water requirement and maize irrigation water requirement shows a downward trend. (2) The spatial distribution of maize irrigation water requirement in Shaanxi Province decreases gradually from north to south. High-value areas are mainly distributed in the northern regions of Yulin City and Yan’an City in Shanbei. Low-value areas are distributed in Ankang City in Shannan. (3) In the face of water scarcity, spring maize should ensure water use during the middle growth period, fast development period, and initial growth periods. Under the same water scarcity conditions, the yield reduction rate is the highest in Guanzhong, followed by the Shannan, and the lowest in Shanbei. This paper aims to provide a scientific and reasonable optimization plan for maize irrigation in Shaanxi Province by calculating and analyzing the maize irrigation water requirement in Shaanxi Province, combined with optimization tools such as genetic algorithms, to address the challenges brought by water resource constraints.