The energy-saving solar greenhouse (ESSG) represents a Chinese-type agricultural building of facilitating low-energy and zero-carbon vegetable overwintering production in high latitudes and cold regions. However, its application benefit outside of China has been limited. To establish an operational ESSG design scheme applicable worldwide, this study developed a comprehensive methodology and specific parameters for different latitudinal regions. The ESSG design was determined based on considerations of daylighting, thermal insulation, heat storage-release capacity, and structural safety. Through validation in six representative regions, the reliability of the ESSG design methodology was confirmed. The optimal design values for front roof angle, ridge height, and back wall height were identified across different latitudes. ESSG in various latitudinal regions from 32°N to 48°N exhibited annual cumulative temperatures could reach 8 × 103∼1.3 × 104°C and accumulated light interception could reach 2 × 1012∼4 × 1012J. Even in the 48°N region, the average internal temperature of the greenhouse exceeded 8 °C, with a nighttime cooling rate lower than 0.75 °C/h and a maximum temperature difference between internal and external environments exceeding 40 °C. This suggests the ESSG fully meets the non-heated overwintering production requirements for common vegetables. The research findings provide crucial theoretical foundations for the global promotion of ESSG, contributing to the reduction of energy consumption and carbon emissions in the sustainable agriculture.