Ukraine's economy is in a state of crisis caused by the war. The agricultural sector in extreme conditions is trying to fulfill its function of ensuring the food security of the state, supporting its export potential despite limited resources and logistical problems. Agrarian science in the conditions of budget funding deficit is trying to find ways to use the scientific and experimental base, developed varieties and technologies to promote the stabilization and revival of agro-industrial production in the industry and regions. Effective models of implementing the innovative potential of agrarian science on a business basis are necessary.The purpose of the study is to justify the platform of market adaptation of science to crisis conditions and the mobilization of scientific potential in the breakthrough directions of the development of the agrarian sphere on the basis of innovative bioeconomy and close cooperation between science and business.To realize the set goal, the work assessed the possibilities of integrating science and business on the platform of innovative bioeconomy in the crisis economic and legal conditions of Ukraine; the bio-ecosystem of the platform and its operational mechanism of the partnership of science and business for the implementation of joint innovation and investment projects are substantiated. For the introduction of a well-founded bioecosystem, a set of measures is proposed for the formation of a platform in the system of agrarian science on the basis of conducted tests and adopted organizational decisions based on the example of the National Academy of Agrarian Sciences of Ukraine. Cooperation between agricultural science and business on the basis of the proposed public-private partnership platform ensures the mobilization of scientific potential to solve pressing issues of innovative development of agricultural production, rural areas through the creation and transfer of breakthrough and supporting bioinnovations, the production of competitive innovative agro-food products.