The Asian region, most populous and fastest growing in terms of economic growth, has countries with lowest per capita energy/electricity consumption. Barring the Middle East, the rest of the region is, by and large, modest in conventional energy resources. This is also a region where large sections of population suffer from income inequality and inadequate economic development. Economic growth and quality of life of a population depend heavily on per capita availability of energy/electricity, and thus there is an urgent need to increase the per capita electricity production/consumption in the region. Unlike in the past, it is the Asian region that is poised to dwarf the today's developed world in new capacity addition in the coming years. This fact alone asks for sensible choices to be made. Also, the Asian region is quite vulnerable to the effects of climate change, given the geography and population distribution. Today, governments must seriously consider the environmental impact of electricity generation, in order to help mitigate global warming and its consequences. Nuclear power, being environmentally benign, affords sustainability at the very outset. But that's not all. The other compelling reasons in favour of nuclear power are its compact nature as a source of energy and the promise of long-term energy security. Nuclear power is, therefore, inevitable for the region. Recognising this, the rapidly developing countries in the region – such as India and China – are pursuing ambitious nuclear power programmes, while several other countries in the region are also planning to embark on the nuclear power route for electricity generation. As nuclear power is inherently technology-intensive, there is a need for greater cooperation, to reach out to countries that presently do not have the technology base for starting nuclear power programmes on their own. Even in the countries with established commercial nuclear power programmes, there is a need to reach out to the people to demonstrate the merits, safety aspects and economic competitiveness of nuclear power, and also the role of nuclear power in the preservation of the environment. The imperatives of the current scenario warrant building confidence among the people regarding nuclear power through sharing of credible information on all its aspects to remove misconceptions. This paper describes the current scenario, key issues, challenges and possible ways to address them. The paper also briefly describes the Indian nuclear power programme for being the second-most aggressive player in the nuclear arena in this region, after China.