Iron is crucial for the functioning of neurons. However, the accumulation of iron in subcortical structures, particularly in the putamen, has been linked to age-related decline in cognitive function and neurodegeneration. This accumulation leads to oxidative stress, which damages cellular components and contributes to the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Quantitative Susceptibility Mapping (QSM) has provided insights into the paramagnetic properties of iron, enabling the non-invasive measurement of iron deposits in brain structures. Studies have shown a significant correlation between increased iron levels in the putamen and the severity of neurodegenerative diseases, highlighting the vulnerability of the putamen to iron-induced toxicity. QSM holds promise as an imaging biomarker for understanding disease mechanisms, assessing disease severity, and monitoring treatment. However, further longitudinal studies are needed to evaluate the progression of iron deposition and its implications for disease pathology.