Age-related Changes In Blood Pressure Research Articles

The long and the short of it: Salivary telomere length as a candidate biomarker for hypertension and age-related changes in blood pressure.

Hypertension becomes more prevalent with increasing age. Telomere length (TL) has been proposed as a candidate biomarker and can be accessibly extracted from saliva. However, clarity is needed to evaluate the suitability of using TL as a predictor in such instances. This study investigated salivary TL in a cohort of older adults from the 2008 Health and Retirement Study (n = 3329; F: 58%, mean age: 69.4, SD: 10.3 years) to examine any associations with blood pressure (BP). A Bayesian robust regression model was fit using weakly informative priors to predict the effects of TL with age, sex, systolic BP (SBP), diastolic BP (DBP), and treatment status. There were small effects of treatment (β: -0.07, 95% CrI [-0.33, 0.19], pd: 71.91%) and sex (β: -0.10, 95% CrI [-0.27, 0.07], pd: >86.78%). Population effects showed a reduction of 0.01 log2 units in TL with each year of advancing age (95% CrI [-0.01, -0.00]). Conditional posterior predictions suggest that females, and treated individuals, experience greater change in TL with increasing age. Bayes R2 was ~2%. TL declines with increasing age, differs between sexes, and appears to be influenced by antihypertensive drugs. Overall, all effects were weak. The data do not currently support the suitability of salivary TL as a biomarker to predict or understand any age-related changes in BP.

Age-Related Changes In Blood Pressure Among Young Adults

Blood pressure is the common name for what is technically known as systemic arterial pressure, which is the pressure inside the major arteries that feed the body's circulatory system. This number delineates the systolic and diastolic components of blood pressure. One of the most closely watched clinical markers, blood pressure, is essential in charting treatment progress. The importance of measuring blood pressure stems from the correlation between present blood pressure and the possibility of future health problems. A person's arteries and heart must work harder when blood pressure is high. In the long run, this stress may make the arteries less elastic, less intense, and thicker, all of which are bad. Monitoring a patient's blood pressure is crucial to ensure it doesn't rise to dangerous levels. High blood pressure, often known as HBP, is a severe health problem. The illness is sometimes called "the silent killer" due to the lack of apparent symptoms. For instance, a medical professional may quickly monitor the patient's blood pressure [1, 2]

Estimating biological age of the autonomic regulation cardio-vascular system

Abstract. Based on our data on age-related changes in blood pressure, ECG, and HRV, we developed a method for assessing the cardiovascular system's biological (functional) age. We set ourselves the task of finding a simple non-invasive method for the integral assessment of the state of the cardiovascular system, which allows us to quantify the degree of age-related changes in this system. The essence of the method lies in the fact that the BA of the cardiovascular system is calculated according to the indicators of BP, QT and HRV. The study included 108 practically healthy people aged from 20 to 90 years. The formula for calculating BA was obtained by multiple stepwise regression. The multiple correlation between biological age and chronological is high (r = 0.895; p <0.00001). The average absolute value of the error of BA calculation, in this case, is 5.19 years. Thus, the method for assessing the rate of ageing developed by us has high accuracy and can be used to assess the risk of developing age-dependent cardiovascular pathology. The implementation of the proposed method will allow not only to identify people with the risk of developing pathology but also to assess the effectiveness of treatment, prophylactic and rehabilitation measures. Keywords: biological age; heart rate variability

Characteristics of age-related changes in blood pressure, oxyhemoglobin saturation, and physique in Bolivians residing at different altitudes: presentation of basic data for health promotion.

[Purpose] To present basic data for a health promotion plan tailored to the body function of Bolivians residing in different municipalities and altitudes by investigating their blood pressure and oxyhemoglobin saturation. [Participants and Methods] The participants were 589 Bolivians residing in different altitudes who voluntarily participated in health promotion activities. We measured the blood pressure, peripheral capillary oxygen saturation, height, and weight, and calculated the body mass index. We divided the participants into two groups based on the altitude (valley and lowland) and the participants of each altitude group into six age brackets (every 10 years) to investigate the effect of age on each value. [Results] The altitude affected the systolic and diastolic blood pressure, oxyhemoglobin saturation, and height. All average values in the valley group were lower than those in the lowland group. There were significant effects in all variables based on age. The body mass index values were significantly higher in participants aged 45–64 years compared to those aged 18–34 years; the average value was 29. [Conclusion] An anti-obesity initiative for health promotion is needed to reduce the risk of health impairment in Bolivians, especially lifestyle-related diseases, such as type 2 diabetes mellitus, cardiovascular diseases, and stroke.

Effect of High-Salt Diet on Age-Related High Blood Pressure and Hypothalamic Redox Signaling

Aim: The aim of this study was to investigate the effect of a high salt (HS) diet on age-related changes in blood pressure (BP) and the possible role played by regulatory central mechanisms. Methods: Young (5 months) and old (27 months) male Fischer 344 × Brown Norway (F344/BN) rats were fed standard chow or 8% HS diet for 12 days. BP and heart rate (HR) were measured by telemetry. Results: Mean arterial BP (MAP) was significantly elevated in old rats during the day and night when compared with young animals. The HS diet further elevated MAP in both age groups, and the increase was more pronounced in the old animals, while HR was not altered by age or HS diet. In addition, cardiovascular responses to restraint stress were diminished in the old when compared with the young and were unchanged with HS diet in either age group. Both age and the HS diet elevated the adrenomedullary mRNA levels of tyrosine hydroxylase, an indicator for sympathoexcitation. HS diet enhanced intracerebroventricular angiotensin II (AngII)-induced BP and HR elevations in both age groups. AngII type 1 receptor mRNA increased significantly in the hypothalamus with age and HS diet. Furthermore, hypothalamic p22^phox mRNA and gp91^phox protein, subunits of NADPH oxidase, as well as NADPH oxidase activity increased with the HS diet in the old animals, whereas antioxidant enzymes that decreased with age yet remained unaltered with the HS diet. Conclusion: Our findings indicate that sensitivity of BP to HS diet increases with age, and that central AngII-induced pressor responses are diminished in old rats compared with the young both under control conditions and during HS diet treatment. These changes are paralleled by increases in the expression and NADPH oxidase activity in the hypothalamus, possibly leading to central oxidative stress-mediated sympathoexcitation and high BP.

Neurocardiovascular instability may modulate end-organ damage: A review of this hypothesis investigating the eye and manifestations of NCVI

Neurocardiovascular instability (NCVI) represents age-related changes in blood pressure and heart rate behaviour. It has been associated with increased leukoaraiosis in the brain and also conditions which are likely to be are related to cerebral end-organ damage, such as stroke and falls. The eye is a ‘window’ into the brain and cardiovascular (CV) system, changes in retinal microvasculature being independently predictive of cardiovascular events. The eye is highly vascular, having two circulatory systems and as such the ideal target end-organ to investigate NCVI and early end-organ damage. The retinal and choroidal circulations of the eye would be vulnerable to NCVI if ocular vasoregulation becomes impaired with age, particularly given the high metabolic activity of the retina. The choroid is predominantly extrinsically regulated by the autonomic nervous system. In patients with NCVI, autonomic dysfunction is more common and thus impairment of the tightly regulated ocular microcirculation may indeed be compromised. We review the evidence for the hypothesis that NCVI may modulate end-organ cardiovascular pathology and that the eye is the ideal target organ to monitor this.

Percentile distribution of blood pressure readings in relation to body mass index: a populationbased cross-sectional study ADOPOLNOR

Recent upward trends toward elevated blood pressure and increased weight expressed in terms of body mass index in children and adolescents call for regular monitoring of their physical growth and age-related changes in blood pressure. This requires adequate tools – reference values of a normal blood pressure range. The main objective of this study was to provide sex- and BMI-specific percentile reference values for systolic and diastolic blood pressure based on the adolescent Polish population, participants in the ADOPOLNOR study. A cross-sectional survey was carried out on a representative, randomly selected cohort of 4,941; 2,451 male and 2,490 female students aged 10–18 years, residents in Wielkopolska province and its capital, the city of Poznań. All examinations were performed in school nursery rooms during morning hours according to standard procedures. Body height and weight were measured and BMI was calculated. Blood pressure was measured twice on each occasion on the right arm using a fully calibrated TECH MED TM-Z mercury gauge sphygmomanometer with sets of exchangeable cuffs and a clinical stethoscope. The blood pressure classification was determined using the surveillance method. For each participant, the mean of measurements taken on each of the three occasions was calculated and served as his/her final blood pressure value. Using the LMS method, fitted percentile curves were created for BMI-related systolic and diastolic blood pressure. The findings revealed that age related blood pressure pattern was similar in boys and girls. It showed a steady increase of systolic and diastolic blood pressure with age. There was a positive correlation between the systolic and diastolic blood pressure indicating that when systolic blood pressure increased so diastolic did (r=0.61 at p<0.01). Boys were likely to have relatively higher mean values of systolic and diastolic blood pressure and steeper slope for BMI-related change in blood pressure than girls. Similar pattern was found for age-related changes in BMI. The quotation of 3rd, 5th, 10th, 15th, 25th, 50th, 75th, 85th, 90th, 95th, and 97th at any given BMI between 12 kg/m2 and 35 kg/m2 provided indication of the entire variation in blood pressure of adolescent males and females aged 10–18 years. The sex- and BMI-specific reference values and charts for systolic and diastolic blood pressure may be a useful tool in monitoring blood pressure for early detection of its abnormal level and treatment of children and adolescents with high blood pressure.

Ambulatory blood pressure monitoring in the elderly: Features and perspectives

Aging leads to a multitude of changes in the cardiovascular system that include a rise in blood pressure. Age-related changes in blood pressure are mainly attributable to an increase in systolic blood pressure, generally associated with a slight decrease diastolic blood pressure. This leads to a widening in pulse pressure. Ambulatory blood pressure monitoring is a useful tool to understand these processes and to refine cardiovascular risk assessment. In the light of emerging data in this area, we reviewed the main features of ambulatory blood pressure in elderly and discussed the evidence showing that ambulatory blood pressure is superior to clinic blood pressure to reflect the true pattern of blood pressure over time. Furthermore, we discussed the role of weight control obtained by fitness programs to prevent an excessive rise in blood pressure with age.A thorough understanding of these concepts is of paramount importance and has therapeutic implications in the growing population of elderly subjects with increased blood pressure.

“From Apennines to Andes:” Does Body Mass Index Affect the Relationship Between Age and Blood Pressure?

See related article, pp 25–33 > … after all those days of travel across that endless plain, he saw before him a chain of mountains which reminded him of the Alps. They were the Andes … > > — Heart Novel , Edmondo De Amicis Even small differences in blood pressure (BP) significantly impact the lifetime risk for cardiovascular disease. In a meta-analysis involving ≈1 million adults with no previous vascular disease enrolled in 61 prospective observational studies, within each decade of age, even minor differences in the usual systolic or diastolic BPs were associated with different risks of mortality for stroke and ischemic heart disease. These age-specific associations were similar in men and women.1 A recent meta-analysis from 18 cohort studies showed a substantially lower lifetime risk of cardiovascular disease in subjects with BP <120/80 mm Hg and low-risk profile than in subjects with higher BP.2 Age is of major importance in determining BP levels, and the age-related rise in BP is primarily responsible for an increase in both incidence and prevalence of hypertension with aging. Some longitudinal surveys of the general population carried out in the past provided an opportunity to explore the relations between changes of BP and age. Studies from industrialized countries confirmed the presence of age-related changes in systolic and diastolic BPs.3–5 A report from 3 different longitudinal Swedish population studies for a total of 1304 men and 1246 women followed for ≤12 years showed that the mean systolic/diastolic BP in untreated subjects increased in men from 138/91 mm Hg at 50 years of age to 159/91 mm Hg at age 79 years and from 123/79 mm Hg at age 38 years to 168/93 mm Hg at age 70 years in women.3 Similar results were obtained from a representative …

Aldosterone synthase gene (CYP11B2) promoter polymorphism as a risk factor for ischaemic stroke in Tunisian Arabs

We investigated the contribution of aldosterone synthase CYP11B2 polymorphism (C-344T) to the age-related changes in blood pressure in stroke patients. Study subjects comprised 329 stroke patients (121 normotensive, 208 hypertensive) and 444 healthy controls. Genotyping was done by PCR-RFLP, and the contribution of CYP11B2 polymorphism to the risk of stroke was analysed by regression analysis. The T allele, and CT, TT, and CT + TT genotypes, independently of sex and age, were significantly associated with increased stroke risk. Varied distributions of CYP11B2 genotypes were noted among patients with respect to gender, age and hypertension status, being pronounced in hypertensive patients. Both systolic and diastolic blood pressure were positively correlated with the presence of T allele. Mean systolic and diastolic blood pressure were significantly higher among young (< 60 years) CT and TT genotype carriers. Regression analysis confirmed the positive association of CT and TT genotypes and systolic blood pressure, and the negative association of diastolic blood pressure with odds of stroke development. Taking normotensive patients as reference, regression analysis identified TT genotype, age and female gender to be independently associated with increased odds of stroke. Compared to CC genotype, CT and TT CYP11B2 genotypes are independently associated with increased stroke index.

Age-Related Changes in Blood Pressure, Heart Rate and Heart Rate Variability in Healthy Beagle Dogs

Age-Related Changes in Blood Pressure, Heart Rate and Heart Rate Variability in Healthy Beagle Dogs

The Mediterranean Diet and Incidence of Hypertension: The Seguimiento Universidad de Navarra (SUN) Study

The Mediterranean diet is receiving increasing attention in cardiovascular epidemiology. The association of adherence to the Mediterranean diet with the incidence of hypertension was evaluated among 9,408 men and women enrolled in a dynamic Spanish prospective cohort study during 1999-2005. Dietary intake was assessed at baseline with a validated semiquantitative food frequency questionnaire, and a 9-point Mediterranean diet score was constructed. During a median follow-up period of 4.2 years (range, 1.9-7.9), 501 incident cases of hypertension were identified. After adjustment for major hypertension risk factors and nutritional covariates, adherence to the Mediterranean diet was not associated with hypertension (the hazard ratio was 1.10 (95% confidence interval (CI): 0.81, 1.41) for moderate adherence and 1.12 (95% CI: 0.79, 1.60) for high adherence). However, it was associated with reduced changes in mean levels of systolic blood pressure (moderate adherence, -2.4 mm Hg (95% CI: -4.0, -0.8); high adherence, -3.1 mm Hg (95% CI: -5.4, -0.8)) and diastolic blood pressure (moderate adherence, -1.3 mm Hg (95% CI: -2.5, -0.1); high adherence, -1.9 mm Hg (95% CI: -3.6, -0.1)) after 6 years of follow-up. These results suggest that adhering to a Mediterranean-type diet could contribute to the prevention of age-related changes in blood pressure.

Is neurocardiovascular instability a risk factor for cognitive decline and/or dementia? The science to date

Neurocardiovascular instability (NCVI) is defined as ‘age-related changes in blood pressure and heart-rate behaviour, predominantly resulting in hypotension and bradyarrhythmia’ The four most common presentations of NCVI are orthostatic hypotension (OH), carotid sinus hypersensitivity/syndrome (CSH/CSS), vasovagal syncope (VVS) and post-prandial hypotension (PPH), although there is considerable overlap between these conditions. The criteria for diagnosis of these syndromes are given in Table 1. Clinically, these conditions manifest as dizziness, falls, pre-syncope and syncope. Older people are more susceptible to NCVI because of age-related physiological changes in the cardiovascular system, the autonomic nervous system, and humoral control of blood pressure. These neurocardiovascular changes are further complicated by co-morbidity and polypharmacy in older people.

Impedance Progress

Changes in global arterial function and blood pressure pulsatility play an important role in the exponential increase in the incidence of various common afflictions of aging. However, our current approach to hemodynamics, evaluating the peak (systolic blood pressure) and trough (diastolic blood pressure) of the blood pressure waveform in the arm, provides a limited view of pulsatile hemodynamics. As a first refinement, blood pressure can be separated into steady-flow and pulsatile components, mean arterial pressure (MAP) and pulse pressure (PP), respectively. Numerous recent studies have shown that many serious clinical events may be more closely linked to PP, which is related to large artery stiffness, rather than MAP, which is determined by small artery function and cardiac output. However, systolic blood pressure or PP in the arm probably does not tell the full story. Conventional brachial systolic blood pressure represents a variable composite of PP (large arteries) and MAP (small arteries), depends on ventricular ejection characteristics and arterial properties, and, because of transmission delays and wave reflection, may not be fully representative of central aortic pressure, which may be more relevant to cardiac and cerebral function. These additional sources of variability may have important implications for the pathogenesis of cardiovascular disease and response to treatment. The study by Segers et al1 in the current issue of Hypertension represents an important step forward in our quest to quantify the effects of regional arterial function on the pathogenesis of cardiovascular disease in the community. The authors are reporting pulsatile hemodynamics from the first round of evaluations in a planned longitudinal, observational study of >2000 initially healthy men and women between 35 and 55 years of age recruited from 2 adjacent communities in the suburbs of Brussels, Belgium. The Asklepios investigators assessed pulsatile hemodynamics using a noninvasive approach first developed by Kelly …

Estrogens, Salt, Blood Pressure, and Cardiovascular Disease in Women

Until recently cardiovascular disease in women has been a largely neglected and poorly understood issue, in part related to the misconception of a lower incidence among females compared with males, underrepresentation of females in clinical trials and observational studies until recently, and nontraditional presentation of symptoms in many females. Women have been typically viewed as largely protected from cardiovascular disease until menopause, and thereafter a rise in prevalence has been recognized, presumably related to hormonal decline. Hormonal replacement therapy (HRT) has been viewed as a useful prophylactic approach to ward off such events after menopause as well as to minimize menopausal symptoms. However, recent studies have yielded conflicting results regarding the protective effects of estrogen administration in preventing myocardial infarction and stroke.1–3 Indeed, the results of the Women’s Health Initiative have been interpreted as showing a neutral effect of estrogen administration in women in the 50 to 59 age decile and an adverse cardiovascular effect in older subjects.1 Whereas different pharmacological regimens may have been used in these replacement trials, the impact of these regimens on known risk factors for cardiovascular disease, such as blood pressure, lipoprotein profiles, insulin sensitivity, endothelin, C- reactive proteins, and other vasoactive substances, has not been carefully investigated. The relationship between estrogen and progesterone administration in the form of oral contraceptives and blood pressure, a major risk factor for stroke and cardiovascular disease, has been recognized for 4 decades.4 Population studies have documented a small but significant rise in systolic blood pressure in women receiving oral contraceptives in the 1970s, but only a small proportion of such women demonstrated a rise into the hypertensive range. Whereas epidemiologists remind us repeatedly that a …

Aldosterone synthase gene polymorphism, stroke volume and age-related changes in aortic pulse wave velocity in subjects with hypertension

In rats, chronic aldosterone administration with high diet intake increases aortic stiffness independent of mechanical stress. In hypertensive humans, enhanced plasma aldosterone and arterial stiffness are positively associated. Whether the aldosterone synthase gene polymorphism (ASGP) CYP11B2 influences the age-related changes in blood pressure (BP) and arterial stiffness in hypertensive subjects has never been investigated. In 425 untreated hypertensive men and women, ASGP was evaluated together with aortic pulse wave velocity (PWV). In 191 of these subjects, cardiac haemodynamics were measured using echo-Doppler techniques. In the overall population, independently of sex, the TC and CC genotypes of ASPG had significantly higher heart rate (HR) (P < 0.05) and lower stroke index (P < 0.01) than the TT genotype, but did not affect BP. In men, the adjusted slopes of the curves relating age to PWV and HR were significantly steeper (P = 0.04; P = 0.002) for the TC and CC than for the TT genotype. Such gene-related differences were not observed for the age-systolic BP relationship. In hypertensive subjects, the TC and CC genotypes of ASGP involve, by comparison with the TT genotype, significantly higher HR and reduced stroke index. In men with the C allele, the reduced stroke index (cardiac effect) compensates for the steep increase of PWV with age (arterial effect), thus modulating the cardiovascular phenotype and explaining the lack of increased incidence of systolic hypertension. The results are consistent with a local role of endogenous aldosterone on both heart and vessels.

Dietary calcium lowers the age-related rise in blood pressure in the United States: the NHANES III survey.

This analysis of the third National Health and Nutrition Examination Survey (NHANES III) was designed to investigate the impact of dietary calcium intake on age-related changes in blood pressure and pulse pressure. Data on 17,030 participants 20 years or older (mean age, 48.8+/-0.2 years; 47% male, 42% Caucasian, and 28% African American) were used. Data included demographics, body mass index, blood pressure, and daily dietary calcium. Overall, average calcium intake was 761 mg/day. After adjusting for demographic and anthropomorphic variables, as well as total energy consumption, higher calcium intake was associated with lower rates of age-related increases of systolic blood pressure and pulse pressure (p<0.001). If the calcium intake of the general population were to increase to above 1200 mg, the incidence of isolated systolic hypertension in the elderly might be decreased.

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease.

Our population is aging; in the United States today there are 35 million people 65 years of age or older. That number will double by the year 2030 (Figure 1). Although epidemiological studies have discovered that lipid levels, diabetes, sedentary lifestyle, and genetic factors are risk factors for coronary disease, hypertension, congestive heart failure, and stroke, the quintessential cardiovascular diseases within our society, advancing age unequivocally confers the major risk. The incidence and prevalence of these diseases increase steeply with advancing age (Figure 2). Not only does clinically overt cardiovascular disease increase dramatically with aging, but so do subclinical or occult diseases, such as silent coronary atherosclerosis. Figure 3 (top) shows that a substantial percentage of older, community-dwelling, otherwise healthy volunteers have evidence of inducible ischemia during combined thallium/ECG treadmill stress testing, and their prognosis is poor compared with their counterparts without subclinical coronary disease (Figure 3, bottom). Figure 1. The demographic imperative. Numbers of persons 65 years of age or older (light bars) and 85 years of age or older in the United States from 1900 through 2030. Data taken from the US Census Bureau data with projections for 2030. Figure 2. A, Prevalence of hypertension, defined as systolic blood pressure ≥140, diastolic blood pressure ≥90, or current use of medication for purposes of treating high blood pressure. Data are based on National Health and Nutrition Examination Survey III (1988–1991) (Burt VL, Whelton P, Roccella EJ, et al. Prevalence of hypertension in the US adult population: results from the Third National Health and Nutrition Examination Survey, 1988-1991. Hypertension . 1995;25:305–313). B, Incidence of atherothrombotic stroke (per 1000 subjects per year) by age in men (light bars) and women (dark bars) from the Framingham Heart Study. Data from Wolf PA. Lewis A. Conner lecture: contributions of epidemiology to the …

Effects of blood pressure on neuropsychological functioning in Alzheimer’s disease

Blood pressure is often lower among patients with Alzheimer’s disease (AD) compared to nondemented older adults. Lower blood pressure in AD correlates with reduced cerebral blood flow and cortical atrophy, but its effect on neuropsychological functioning is unclear. We assessed the effects of blood pressure on tests of dementia severity, attention, memory, language, verbal and nonverbal reasoning, motor/psychomotor functioning, and activities of daily living (ADL) among probable AD patients ( n=609). As hypothesized, lower systolic blood pressure (SBP) predicted reduced attention (Digits Forward and Backward), memory (Visual Reproduction I), and ADLs. Unexpectedly, lower pulse pressure (SBP–DBP) predicted greater dementia severity (Mini-Mental State Examination, MMSE), attention (Digits Forward and Backward), memory (Logical Memory I and Visual Reproduction I), and ADLs. These findings may reflect a tendency for less severely demented patients to exhibit normal age-related changes in blood pressure, whereas abnormal patterns may develop with increased dementia severity.

Effects of blood pressure on neuropsychological functioning in Alzheimer's disease

Blood pressure is often lower among patients with Alzheimer's disease (AD) compared to nondemented older adults. Lower blood pressure in AD correlates with reduced cerebral blood flow and cortical atrophy, but its effect on neuropsychological functioning is unclear. We assessed the effects of blood pressure on tests of dementia severity, attention, memory, language, verbal and nonverbal reasoning, motor/psychomotor functioning, and activities of daily living (ADL) among probable AD patients (n=609). As hypothesized, lower systolic blood pressure (SBP) predicted reduced attention (Digits Forward and Backward), memory (Visual Reproduction I), and ADLs. Unexpectedly, lower pulse pressure (SBP–DBP) predicted greater dementia severity (Mini-Mental State Examination, MMSE), attention (Digits Forward and Backward), memory (Logical Memory I and Visual Reproduction I), and ADLs. These findings may reflect a tendency for less severely demented patients to exhibit normal age-related changes in blood pressure, whereas abnormal patterns may develop with increased dementia severity.