Men In Age Group Research Articles

Age-related annual changes in arterial stiffness in healthy adults: Insights from a large Korean cohort study

Background and aimsArterial stiffness, a known cardiovascular risk factor, is associated with increasing age and arteriosclerosis. This study examines age-related annual changes in arterial stiffness in a large cohort of healthy individuals without cardiovascular disease, hypertension, or diabetes mellitus. MethodsThe study included 195,405 Korean adults aged 30–79 years who attended a health check-up between 2006 and 2019. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV), and the final cohort for the baPWV annual change analysis comprised 147,313 participants. ResultsThe study found that baPWV values increase progressively with age in both sexes, with the most notable changes occurring in the 70–79 age group. The spread in baPWV measurements, as indicated by the interquartile ranges, generally increases with age but was particularly pronounced in women in the 50s and 60s age groups, with men showing a greater spread in the 70–79 age group. The average annual change in baPWV (ΔbaPWV) values increased from 1.48 cm/s (95 % CI: 0.80–2.16) in the 30–39 age group to 23.72 cm/s (95 % CI: 16.25–31.19) in the 70–79 age group in men. Similarly, for women, the average ΔbaPWV values increased from 1.80 cm/s (95 % CI: 0.93–2.68) to 18.51 cm/s (95 % CI: 7.18–29.85) in the 30–39 and 70–79 age groups, respectively. The study observed that arterial stiffness in men consistently increases across all age groups, whereas in women, it does not significantly increase annually before age 50 but shows a steeper rise after this age. ConclusionsThis study emphasizes the progressive nature of arterial stiffness with aging in a healthy population. It highlights notable differences in the rate of progression and the distribution of baPWV between men and women, with men exhibiting a greater spread in the oldest age group.

Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: A Turkish Study.

Earlier research has suggested gender differences in event-related potentials/oscillations (ERPs/EROs). Yet, the alteration in event-related oscillations (EROs) in the delta and theta frequency bands have not been explored between genders across the three age groups of adulthood, i.e., 18-50, 51-65, and >65 years. Data from 155 healthy elderly participants who underwent a neurological examination, comprehensive neuropsychological assessment (including attention, memory, executive function, language, and visuospatial skills), and magnetic resonance imaging (MRI) from past studies were used. The delta and theta ERO powers across the age groups and between genders were compared and correlational analyses among the ERO power, age, and neuropsychological tests were performed. The results indicated that females displayed higher theta ERO responses than males in the frontal, central, and parietal regions but not in the occipital location between 18 and 50 years of adulthood. The declining theta power of EROs in women reached that of men after the age of 50 while the theta ERO power was more stable across the age groups in men. Our results imply that the cohorts must be recruited at specified age ranges across genders, and clinical trials using neurophysiological biomarkers as an intervention endpoint should take gender into account in the future.

Indirect Determination of Hematological Reference Intervals in Healthy Moroccan Adults Using Outpatient Data.

Reference intervals are essential for the interpretation of clinical laboratory tests and patient management. This study aims to determine age and gender reference intervals of complete blood count (CBC) in the Moroccan population by using the indirect approach. The study used data of ostensibly healthy adults collected retrospectively using the laboratory information system (LIS) of the Laboratory for Research and Medical Analysis of the Fraternal Royal Gendarmerie in Rabat (Morocco), between January 2018 and February 2020. The study included 5,898 men and 10,172 women ranging in age from 18 to 90 years. The lower and upper reference limits of CBC parameters were calculated using the nonparametric technique, as suggested by the Clinical and Laboratory Standards Institute (CLSI). All hematological parameters showed no clinically significant gender-related differences, except small differences in the values of hemoglobin (HB), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). There were also no clinically significant agerelated differences for median values of all hematology analytes in both genders, except for platelet count (PLT) that continued to decline with increasing age in men and women, and Red blood cell count (RBC), Hematocrit (HCT), and hemoglobin (HB) that tended to increase with age but decrease in older age groups in men while they tended to increase with age in women. The indirect method can be used to establish reference intervals for CBC, with appropriate selection criteria and statistical tools. Our findings differed from the reference ranges provided in the textbook and also in other countries' reports.

Semenogram Characteristics in Correlation with Hormonal Studies among Different Age Groups of Men - Damietta Governorate

Semenogram Characteristics in Correlation with Hormonal Studies among Different Age Groups of Men - Damietta Governorate

Erectile Function in Men during the COVID-19 Pandemic

This research focused on two age groups of men (under 40 and over 40 years) and their sexual function during the COVID-19 pandemic. Somatic examinations, including the measurement of hormone levels, were conducted on all patients. The subjects also completed two questionnaires and provided personal history data. The first questionnaire covered the evaluation of erectile function, while the second assessed psychosocial trauma and stress. The results in the first group (men under 40 years of age) showed a correlation between prolactin values and erectile function score results (R = 0.54), between erectile function score results and trauma and psychosocial stress symptoms (R = 0.49) and also between prolactin values and trauma and psychosocial stress symptoms (R = 0.53). The results in the second group (men over the age of 40) showed a correlation between prolactin values and erectile function score results (R = 0.42), between erectile function score results and trauma and psychosocial stress symptoms (R = 0.54) and between free testosterone level and erectile function score results (R = 0.32). These findings support the hypothesis of a different impact of stress on the development of erectile dysfunction in men under 40 and over 40 years of age during COVID-19.

(359) Vasectomy Trends in Western NY Following Dobbs v. Jackson Women’s Health Organization

Abstract Introduction On June 24, 2022, the United States Supreme Court ruled on Dobbs v. Jackson Women’s Health Organization (Dobbs) that the Constitution of the United States does not confer a right to abortion. The court’s decision overruled both Roe v. Wade (1973) and Planned Parenthood v. Casey (1992), giving individual states the full power to regulate any aspect of abortion not protected by federal law. Objective Our study aims to identify the difference, if any, in the number of vasectomies performed in Western NY before and after the ruling on Dobbs v. Jackson Women’s Health Organization. Methods We performed a retrospective chart review of 2428 patients who had vasectomies in Western New York from August 2021 – March 2023. Leveraging a dataset containing de-identified patient information, we compared the rates of all men undergoing vasectomies in the six-month period before and after the ruling. Vasectomy case information collected by urologists in Buffalo dating back to 1996 was collected and tabulated using Excel. Statistical analyses were performed to compare differences in both the overall change in frequency of vasectomies among all men in the six-month period before and after the court decision, as well as by specific demographic groups. Statistical analyses were performed in R and SAS. Results Men with no children had a statistically significant increase (p=0.009) in the number of vasectomies in the six-month period after the Dobbs decision (n=138) compared to before (n=98). Rates of vasectomies pre- and post- Dobbs were organized by age quartiles (<33.20, 33.20-36.65, 36.66-40.59, ≥40.60). In the “No Child” group, men with ages <33.2 (p=0.0137) and ages 33.2-36.65 (p=0.0394) had significant increases in frequency of vasectomy after the court decision. Conclusions Our data demonstrates that in the wake of Dobbs v. Jackson Women’s Health Organization (2022), the number of vasectomies among men with no children significantly increased after the court decision. There were significant increases in the number of vasectomies within different age groups of men without children following the decision. Future aims of this study will seek to create statistical models to determine the underlying reasons that influenced the observed change in frequency of vasectomies following the court decision in men without children. Disclosure No.

Direct and indirect impact of COVID-19 on life expectancy at birth in Chile in 2020

This article shows the direct and indirect impacts of COVID-19 on life expectancy in Chile in 2020, based on mortality statistics published in March 2023. To this end, a counterfactual mortality was estimated for 2020 without COVID-19; based on the pattern of mortality by cause of death from 1997 to 2019, mortality charts were created to calculate life expectancy from 2015 to 2020 and an estimation for 2020, and the difference between expected and observed life expectancy in 2020 was then separated by age group and cause of death. Life expectancy in 2020 interrupted the upward trend from 2015 to 2019, showing a decline of 1.32 years in men and 0.75 years in women compared to 2019. Compared to the estimated 2020, life expectancy was 1.51 years lower in men and 0.92 years lower in women, but the direct impact of COVID-19 on the decrease in life expectancy was greater (1.89 for men and 1.5 for women) in the 60-84 age group in men and the 60-89 age group in women. The direct negative impact of COVID-19 on life expectancy was partially mitigated by significant positive indirect impacts on two groups of causes of death: diseases of the respiratory system and infectious and parasitic diseases. This study shows the need to differentiate direct and indirect impacts of COVID-19, due to the implications for public health when the intensity of COVID-19 decreases and mobility restrictions are suspended.

Dietary Intakes of Community-Dwelling Adults in the United States across Older Adulthood: National Health and Nutrition Examination Survey 2015–March 2020

BackgroundDietary guidance is set on the basis of age and life stage and defines older adults as ≥60 y. Yet, little is known about if and/or how diet quality differs beyond the age of 60. ObjectiveThe objective of this study was to compare the dietary intakes of 60–69 (n = 2079), 70–79 (n = 1181), and 80+ y old (n = 644) noninstitutionalized men and women in the United States using the Healthy Eating Index 2015 (HEI) and the What We Eat in America food categories. MethodsData were obtained from National Health and Nutrition Examination Survey 2015–2016 and 2017–March 2020. HEI and component scores were calculated using the population ratio method. Population estimates for dietary intake were calculated as the average reported over 2 separate nonconsecutive 24-h dietary recalls. ResultsIn men and women, the reported energy intake was lower among the 80+ y olds (kcal/d men—80+: 1884 ± 30, 70–79: 2022 ± 33, 60–69: 2142 ± 39; women—80+: 1523 ± 36; 70–79: 1525 ± 33, 60–69: 1650 ± 25; P-trend < 0.001). Total HEI scores did not differ significantly across the 3 age categories, but the 80+ y olds had significantly lower scores for the green vegetables and beans component than the 60–69 y olds [men—mean (95% confidence interval): 2.0 (1.5, 2.5) compared with 3.4 (2.6, 4.1); women—2.3 (1.8, 2.8) compared with 4.4 (3.7, 5.0)]. In women, the percentage of daily calories from protein was significantly lower in the 80+ y olds than in the 60–69 and 70–79 y olds (12.9% ± 0.6%, compared with 17.0% ± 0.9% and 15.6% ± 0.6%, respectively). Protein intake did not differ significantly among the 3 age groups in men. The 80+ y old men and women reported consuming a significantly higher percentage of calories from snacks and sweets compared with the 60–69 y olds (men—80+: 18.1% ± 0.8%, 60–69: 15.4% ± 0.7%; women—80+: 19.6% ± 0.8%, 60–69: 15.5% ± 0.7%). ConclusionThe diet of 80+ y olds differed from that of 60–69 y olds in some key components, including energy, snacks and sweets, protein, and green vegetables. Future research is needed to determine if there are health-related consequences to these differences.

Morphological Evaluation of the Incisive Canal in the Aspect of the Diagnosis and Planning of Orthodontic Treatment—CBCT Study

Background: Understanding the anatomy of the incisive canal is crucial for effective diagnosis and treatment planning in clinical orthodontics. This is because, during orthodontic tooth movement, there is a risk of contact between the roots of the upper central incisors and the incisive canal. Objective: The aim of this study was to assess the anatomical variability of the incisive canal using cone beam computed tomography (CBCT), as well as to evaluate its correlation with age, sex, and the position of the maxillary central incisors. There are only a few studies on this topic. Materials and methods: We analysed CBCT data from 67 patients aged from 13 to 49 years. This study was conducted at the Wroclaw Medical University. Measurements were performed twice by two independent researchers, and intra-observer error and correlation were calculated. The mean difference between the first and second observations and between observers was also assessed. We examined the dimensions of the incisive canal and its relationship to the roots of the upper central incisors in relation to age and gender. Results: Our study results revealed a significant correlation between the width and length of the incisive canal. Males exhibited a significantly greater canal length at the lowest point of the incisive canal on the palatal wall. Additionally, males had wider canals compared to females. The analysis of canal width and distance between the most mesial point of the root and the line passing through the most anterior point of the incisive canal showed a negative correlation in all age groups of men. The analysis of incisal inclination and incisal canal inclination showed a very strong relationship, especially in the age group of 13 to 20 years. Several potential risk groups of contact between the roots of central incisors and the incisive canal have been identified based on their structure and the planned incisors’ orthodontic movement. Conclusions and implications: Knowledge of the anatomy of the incisive canal and the use of 3D imaging in high-risk patients can prevent resorption of the incisor root by considering the individual anatomical conditions of the patient when planning orthodontic tooth movement. We recommend performing a CBCT scan before starting orthodontic treatment in the case of moderate and significant retraction of the incisors, or a significant change in their inclination due to the wide anatomical diversity of the incisive canal, especially in adult patients.

Comparison of thirty-year survival in the populations of Russia and the United States of America

Aim. To compare survival at a 30-year follow-up in the populations of Russia and USA.Material and methods. From the Russian studies of 1975-1982, 14728 men and 6140 women aged 18-71 years were included, with follow-up until 2017 (501016 person-years of follow-up). In addition, 2265 men and 2345 women aged 18-71 years from the US population (The Third National Health and Nutrition Examination Survey) were compared with survey data in 1988-1994, with mortality follow-up until 2019 (115523 person-years of follow-up). Kaplan-Meier curves were created in groups of men and women aged 18-29, 30-39, 40-49, 50-59, 60-71 years old. All-cause death was taken into account as an outcome. We analyzed the prevalence of a number of cardiovascular risk factors.Results. Comparison of Kaplan-Meier curves in Russia and USA shows significant differences in all five age groups of men; in Russia the prognosis was worse (p=0,000). In women, significant differences of the same direction appear only at the age of ≥60 years (p=0,003). Comparison of the prevalence of risk factors showed that in Russia hypertension occurs several times more often than in the United States, while the differences are significant in all age groups of men and women.Conclusion. At a 30-year follow-up, the prognosis for Russia is worse compared to the United States for all age groups of men and for women &gt;60 years of age.

The distribution of blood pressure and associated factors of the elderly with type 2 diabetes in Jiangsu Province

Objective: To investigate the distribution of blood pressure and analyze the associated factors of blood pressure of the elderly with type 2 diabetes in Jiangsu Province. Methods: The elderly over 60 years old participants with type 2 diabetes in the communities of Huai'an City and Changshu City, Jiangsu Province were selected in this study. They were divided into two groups: taking antihypertensive drugs and not taking antihypertensive drugs. The demographic characteristics, such as age and sex, and relevant factors were collected by questionnaire. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured by physical examination. The percentile of SBP and DBP in each age group of men and women were described. The kernel density estimation curve was used to show the blood pressure distribution. The trend of blood pressure with age was fitted by locally weighted regression. The logistic regression model was used to analyze relevant factors of blood pressure. Results: A total of 12 949 participants were included in this study, including 7 775 patients in the antihypertensive drug group and 5 174 patients in the group without antihypertensive drugs. The SBP of participants was concentrated at 140-160 mmHg, and their DBP was concentrated at 75-85 mmHg. There were significant differences in the distribution of blood pressure among the subgroups of body mass index (BMI) and rural areas whether taking antihypertensive drugs and not. For participants aged under 80 years old, the SBP showed an increasing trend with age and the DBP showed a decreasing trend with age. Age, BMI ≥24 kg/m2, fasting blood glucose ≥7.0 mmol/L, living in rural areas and no smoking were influencing factors of the elevated SBP; BMI ≥24 kg/m2, male, living in rural areas, no smoking, drinking alcohol and not receiving drug hypoglycemic treatment were influencing factors of the elevated DBP. Conclusion: The SBP of older diabetic adults in Jiangsu Province is at a high level, and the distribution of blood pressure is significantly different between men and women in taking antihypertensive drugs group. The SBP presents a rising trend and the DBP is decreasing at the age of 60-80 years. The blood pressure level of this population are mainly affected by age, BMI, urban and rural areas, smoking.

European cancer mortality predictions for the year 2023 with focus on lung cancer

We predicted cancer mortality figures for 2023 for the European Union (EU-27), its five most populous countries, and the UK. We also focused on mortality from lung cancer. Using cancer death certification and population data from the World Health Organization and Eurostat databases for 1970-2018, we predicted numbers of deaths and age-standardized rates (ASRs) for 2023 for all cancers combined and the 10 most common cancer sites. We investigated the changes in trends over the observed period. The number of avoided deaths over the period 1989-2023 were estimated for all cancers as well as lung cancer. We predicted 1 261 990 cancer deaths for 2023 in the EU-27, corresponding to ASRs of 123.8/100 000 men (-6.5% versus 2018) and 79.3 for women (-3.7%). Over 1989-2023, ∼5 862 600 cancer deaths were avoided in the EU-27 compared with peak rates in 1988. Most cancers displayed favorable predicted rates, with the exceptions of pancreatic cancer, which was stable in EU men (8.2/100 000) and rose by 3.4% in EU women (5.9/100 000), and female lung cancer, which, however, tends to level off (13.6/100 000). Steady declines are predicted for colorectal, breast, prostate, leukemia, stomach in both sexes, and male bladder cancers. The focus on lung cancer showed falls in mortality for all age groups in men. Female lung cancer mortality declined in the young (-35.8%, ASR: 0.8/100 000) and middle-aged (-7%, ASR: 31.2/100 000) but still increased by 10% in the elderly (age 65+ years). The advancements in tobacco control are reflected in favorable lung cancer trends, and should be pushed further. Greater efforts on the control of overweight and obesity, alcohol consumption, infection and related neoplasms, together with improvements in screening, early diagnosis, and treatments may achieve a further 35% reduction in cancer mortality in the EU by2035.

Subsequent participation in organized FIT based screening following screen-derived colonoscopy – A Danish nationwide cohort study

IntroductionIn the Danish National Colorectal Cancer (CRC) screening program, participants with screen-detected low-risk adenomas are invited to a new faecal immunochemical test (FIT) screening after two years. However, participation rate in next FIT screening is unknown. We aimed to investigate this subsequent participation rate within the Danish CRC screening program. MethodsThis nationwide register-based study included participants aged 50–72 years registered with FIT screening in the Danish CRC screening program between January 1, 2016, and June 30, 2017. Participants were included if their index FIT was negative or if it was positive and the subsequent colonoscopy detected low-risk adenomas. Invitees were categorized as subsequent participants if they returned a FIT within 135 days following the invitation to screening. We estimated the relative risk for participation depending on screening outcome, age, and sex. Result415,107 with a negative result and 5,550 with low-risk adenomas were included. 86.0% (85.9;86.1) of the invitees with a negative result participated in the subsequent screening, while 71.8% (70.6;73.0) of the invitees with low-risk adenomas participated subsequently. The risk of participation in the subsequent screening was significantly lower among all age groups of men and women with low-risk adenomas compared to similar groups with negative results. ConclusionInvitees with low-risk adenomas detected at their initial colonoscopy are less likely to participate in the subsequent screening than invitees with negative results. This association was found in all age groups and for both sexes. Further studies are necessary to assess whether non-attendance is more pronounced in specific subgroups.

S-15-1: EPIDEMIOLOGY AND CONTROL OF HYPERTENSION IN JAPAN

The national surveys of Japan in the past 60 years showed a steady decrease in mean of systolic blood pressure (BP) among all age groups of men and women, but not in diastolic BP levels, particularly among men. Hypertension prevalence remains high: over 60% of men aged 50 years or over and women aged 60 years or over had hypertension in 2016. However, the control rates of hypertension (BP&lt; 140/90) have continuously improved in the past 40 years, and were around 40% in 2016. Nonetheless, the over 50% prevalence of uncontrolled hypertension would still be the strongest risk factor of cardiovascular diseases in Japan. Of the estimated 43 million hypertensives in Japan, most (31 million, 72%) were under poor control. According to new Japanese hypertension guidelines (JSH 2019), there will be only a small increase (2.2 million, 2.1 percentage points) in adults who are recommended for antihypertensive medication compared with 2014 guidelines. However, an additional 5.3 million (22.1 percentage points) adults taking antihypertensive medication would have a BP above the target defined by JSH 2019. The number of hypertensives with poor control was targeted to decrease by 7 million (from 31 million in 2017 to 24 million in 2028) by the Japanese Society of Hypertension, when the followings are achieved: (1) the prevalence of hypertension decreases by 5 percentage points; (2) the treatment rate of hypertension among hypertensives increases by 10 percentage points; and (3) the control rate of hypertension, defined as BP &lt; 140/90 mmHg, among individuals taking antihypertensive medication increases by 10 percentage points. Both high-risk and population strategies to manage and prevent hypertension deserve greater priority.

Dietary Characteristics of Elders with Frailty and with Mild Cognitive Impairment: Cross-Sectional Findings and Implications from the Nutrition and Health Survey in Taiwan 2014-2017.

It is unclear whether low dietary intake accompanied with multiple nutrient deficiencies or specific nutrient inadequacy is associated with geriatric syndrome. This study aimed to examine the nutrition inadequacy profiles associated with frailty and cognitive impairment (CI). With information from the Nutrition and Health Survey in Taiwan, 2014-2017, sex-specific nutrient intakes and intake per kg of body weight (BW) were estimated from 24-hour recall data for two age groups (65-74 years; ≥75 years) regarding the three frailty and three CI subgroups. Total energy intakes were significantly lower with the severity of both frailty and CI in analysis combining both gender and age groups, and in both the 65-to-74-year-old women or the over-75-year-old women. These trends were observed but not significant in either of the two age groups in men. Significantly lower levels of energy intake have been observed when age, sex, and sampling strata were adjusted. Intake levels of multiple nutrients also decreased with the severity of frailty and CI. A greater number of nutrient inadequacies for the frail and the CI was found in the 65-to-74-year-old group than the over-75-year-old age group. However, most of the associations between micronutrients and the two geriatric syndromes disappeared after energy adjustment. The remaining few did not show consistency across age-sex subgroups. In conclusion, frailty or CI was associated with low amounts of food consumption accompanied by multiple nutrient insufficiencies. Dietary intervention to ensure adequate total energy and multiple nutrient intakes should be trialed in the geriatric population to address both the causal and efficacy issues.

Improved cardiovascular disease risk prediction by implementing sex-specific cut-offs for intervention and new risk markers

Abstract Background More than 17 million people die from cardiovascular disease (CVD) annually. CVDs are preventable and several risk prediction models are available for determining the 10-year risk of CVD, including the Norwegian NORRISK2 model. However, the available risk prediction models only explain a modest proportion of the incidence. For myocardial infarction (MI), it is estimated that 15–20% of the patients have none of the traditional risk factors and would be classified as “low risk”. Purpose Aim was to develop improved models for predicting the 10-year risk of MI. Methods We included 31.946 participants from the third wave of the Trøndelag Health Study (HUNT3) with no previous CVDs. HUNT data included 101 variables from interviews, clinical measurements, and biological samples on each participant. Totally, 11% of the men and 6% of the women experienced an MI between the HUNT3 and HUNT4 (10-year follow-up). The dataset was split 80/20 into a training set and a test set. XGBoost and logistic regression (LR) were used to fit two models for each sex predicting MI including variables from HUNT3. The models were evaluated by the area under the Receiver-Operating-Characteristic (ROC) curve and the Precision-Recall (PR) curve, both for the full test set and the test set divided into age groups. Thresholds for classification were suggested by maximizing different performance measures through 10-fold cross-validation on the training set. We then explored age- and sex-specific thresholds for intervention with a reasonable trade-off between sensitivity and specificity. All results were compared with NORRISK 2, which was implemented and applied to the same test set for exact comparison. Results For men, the XGBoost model improved risk prediction compared to NORRISK 2 for all age groups (AUC-ROC for XGBoost and NORRISK 2, respectively, 0.72 and 0.65 (age 45–54), 0.63 and 0.62 (age 55–64), 0.69 and 0.62 (age 65–74)). The liver-related enzyme alkaline phosphatase (ALP) was among the new predictors for MI in men. For women, NORRISK 2 performed best when evaluated by ROC curves, however, when evaluated by PR curves, the XGBoost models indicated improved prediction compared to NORRSIK 2 in the women 55–64 years (AUC-PR for XGBoost and NORRISK 2, respectively, 0.20 and 0.12). The thyroid stimulation hormone (TSH) was among the new predictors for MI in women. Regarding NORRISK 2, our results indicated that the thresholds for intervention should be increased for all age groups in men and decreased for all age groups in women for improved balance between sensitivity and specificity. Conclusion New risk factors should be considered implemented in CVD risk prediction algorithms, for improved identification of individuals at increased risk of MI. In addition, implementing sex-specific thresholds for intervention could be a useful step towards improved prevention of CVD for both men and women. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Regional Health Authorities

Age-related changes in the glucose level, its metabolites, and aminotransferases activity in women and men of mature and elderly age

BACKGROUND: Adaptation to living conditions in the North in humans is determined by the persons energy status in particular glucose homeostasis, and the activity of several enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT).&#x0D; AIM: To conduct a comparative analysis of the levels of glucose, lactate, pyruvate, the activity of AST, ALT, and the ratio of different age groups in men and women residing in the subarctic region of the Arkhangelsk Region.&#x0D; MATERIAL AND METHODS: This article is an observational cross-sectional uncontrolled study that accounts for the differences in the content of carbohydrate metabolism parameters and transferase activity between groups of women and men of different age periods. 437 women and 194 men aged 2174 years, born and permanent residents of the Arkhangelsk region, were examined. The glucose content of the blood serum was determined by the enzymatic method, the lactate level was measured by the Trinder Reaction, the pyruvate level by the Umbright Method, the activity of AST and ALT by the unified kinetic method, and the values of the AST/ALT ratio (De Ritis ratio) were obtained. The study participants were divided into 4 age groups: women 2135, 3645, 4655, 5674 years, and men 2235, 3645, 4660, and 6174 years.&#x0D; RESULTS: Non-parametric comparison showed an age-related increase in blood glucose in women aged 4655 years accompanied by an increase in the activity of AST and ALT, while in men aged 6174 years, there was a decrease in ALT. This indicates the presence of different mechanisms that accounts for its increase; an increase in the number of people with a critical glucose level (prediabetes 5.66.1 mmol/l and above is normal) in older age groups can serve as a confirmation of the onset of hyperglycemia and could be the cause and/or consequence of the insulin resistance. An individual analysis of the De Ritis ratio showed individuals with different metabolic flows in glucose homeostasis in all gender and age groups. With age in 57.5; 66.7; 59.5 and 52.4% of women and in 72.6; 63.2; 74.1 and 28.6% of men, there were predominated anabolic processes, which, with an increase in glucose, increased the risk of insulin resistance.&#x0D; CONCLUSIONS: The observed features of the state of carbohydrate metabolism and aminotransferases in men and women, taking into account their ages, can contribute to diagnostic and preventive measures aimed at preserving the health of the people living in the Arctic.

Satisfaction with Singlehood and Sexual Activity

The purpose of this paper is to examine the extent to which Norwegians are satisfied with their singlehood, and to determine the association between being single and sexual activity. Data were obtained from a questionnaire survey of a representative web sample of 1076 unpartnered individuals (568 women, 508 men) aged 18–89 years. A total of 45.2% of the single respondents reported being satisfied with being single, while 33.9% reported being unsatisfied. There was no difference between the age groups in men, but more women aged 45 years or older than women under the age of 45 were satisfied with being single. A higher percentage of gay, bisexual, and transmen than heterosexual men was satisfied with being single. More women who had not been sexually active with a partner in the past year were satisfied with being single than were women who had been sexually active. The men who were most satisfied with being single were those who had masturbated and/or had sexual intercourse, and least satisfied were those with no sexual activity, or exclusively masturbation activity. The results are discussed in terms of biological, psychological, and social positions.

Spatiotemporal Clusters and Trend of Trichomonas vaginalis Infection in Korea.

This study was done to provide an overview of the latest trichomoniasis status in Korea by finding disease clusters and analyzing temporal trends during 2012–2020. Data were obtained from the Health Insurance Review & Assessment Service (HIRA) of Korea. SaTScan and Joinpoint programs were used for statistical analyses. Gyeonggi-do had the highest average population and highest number of cases. The high incidence of T. vaginalis infections were observed among women aged 40–49 and 30–39 years (33,830/year and 33,179/year, respectively). Similarly, the 40–49 and 30–39 age group in men showed the highest average cases (1,319/year and 1,282/year, respectively). Jeollabuk-do was the most likely cluster, followed by Busan/Gyeongsangnam-do/Ulsan/Daegu and Jeju-do and Gwangju. Urban and rural differences were prominent. Trichomoniasis has decreased significantly in most clusters, except for Incheon. Trichomoniasis was decreasing in women recently after peaking around 2014. Men showed different trends according to age. Trichomoniasis was increasing in the 10–39 age groups, but decreasing in the 40–59 age groups. This study might provide an analytic basis for future health measures, policy-makers, and health authorities in developing effective system for prevention of trichomoniasis.

Age-related and sexual features of the mobility of the temporomandibular joints

Introduction.Pathology of the temporomandibular joints (TMJ) is widespread even among young people, and the frequency of its occurrence increases with the age of patients. In this case, there is violated one of the main characteristics of the joints — mobility, which is measured by the mouth opening width (MOW). There is not enough information in the literature on the age and sex characteristics of the TMJ mobility in individuals without pathology of this joint.The aimof the study is to research the mobility of the TMJ in different age groups in men and women without pathology of this joint.Materials and methods.There were examined 714 patients who applied for dental care, aged 20 to 79 years (504 women and 210 men), without pathology of the TMJ. The range of motion in the TMJ was measured using a caliper with thin lips during the opening of the mouth in a neutral head position. The subjects were divided into age groups: 20–29, 30–39, 40–49, 50–59, 60–69 and 70–79 years old.Results.It was found that the most common MOW value was 4,9 cm (range from 4,5 to 5,2 cm). A distribution of relative frequencies corresponding to the normal Gaussian distribution was observed for this indicator. The mobility of the TMJ changed little with age. Analysis of the distribution of temporomandibular joint mobility by age groups of patients with a step of 10 years showed the similarity of the average MOW values in all groups of subjects, except for the group of 20–29 years. Their average values (4,75 cm) were lower than those of the other groups (4,9 cm,p&lt;0,05). It was found that men have a higher mobility of the TMJ compared to women in all age groups (on average by 0,28 cm,p&lt;0,05).Conclusion.Mouth opening widths of 4,6 to 5,2 cm (average 4,9 cm) can be considered as normal. TMJ mobility is not related to age. Consequently, a decrease in the mobility of the TMJ in persons of older age groups cannot be considered as normal age-related changes. TMJ mobility depends on sex. Men have higher TMJ mobility than women in all age groups. Thus, the TMJ differ from other joints not only in their complexity (two joints always work together), but also in age and sex patterns of mobility.