Agar Hydrogel Research Articles

Influence of cellulose on the properties of physically cross-linked poly(vinyl alcohol)/Agar double network hydrogels and investigation of multifunctional flexible sensors

With the slogan "double carbon target" coming into the public's view, green, healthy, non-toxic and harmless hydrogel flexible sensors have become one of the research subjects of many staff. But most hydrogels need a crosslinking agent to complete polymerization. In this work, a PVA (poly (vinyl alcohol))/Agar hydrogel material was designed to form three-dimensional reticulated composite hydrogels with a variety of cellulose, and more green and healthy citric acid was used instead of PVA crosslinker to promote hydrogel polymerization. Through the test of four kinds of cellulose, it was found that PVA/ HPMC ( (Hydroxypropyl)methyl cellulose)/Agar hydrogel has the most outstanding performance, its mechanical property is 1.77MPa, its elongation at break can reach 766%, and it has good recovery performance, fatigue resistance and good adhesion. After it is applied to the flexible hydrogel sensor, its gauge factor value is as high as 5.94 under the strain of more than 200%. When simulating human skin and detecting human motion, the electrical signal changes sensitively and repeatedly, and has a good response when testing temperature and humidity. PVA/HPMC/Agar hydrogel provides a more healthy solution for flexible electronic devices.

Visual tracking of real-time freshness of fish using an agar hydrogel colorimetric indicator containing CuNPs/NCQDs

A simple, selective, and affordable dual fluorescence-colorimetric indicator for hydrogen sulfide was developed based on a complex of copper nanoparticles and N-doped carbon quantum dots (CuNPs/NCQDs). Real-time and visual freshness tracking of fish was done using a colorimetric indicator by incorporating CuNPs/NCQDs into agar hydrogel (AH-CuNPs/NCQDs). The fluorescence response of the CuNPs/NCQDs solution is quenched upon exposure to H2S. The field-emission scanning electron microscopy image of the AH-CuNPs/NCQDs film revealed a unified structure. The prepared indicator exhibited a good and irreversible response to H2S, with a LOD of 91.36 and a LOQ of 276.86 μM, based on the localized surface plasmon resonance (LSPR) mechanism. The X-ray photoelectron spectrometer and Fourier transform infrared spectrometer results confirmed the formation of a CuS bond in the colorimetric indicator exposed to fish spoilage. The prepared indicator demonstrated good stability and remained unaffected by pH or other volatile compounds. Notably, there was a strong correlation between ΔΕ and fish freshness parameters (pH, TV-BN, and TVC). Light green, pale yellow, and dark yellow colors, respectively, indicated freshness, semi-freshness, and spoilage of fish during storage in the refrigerator. Overall, the prepared indicator can be effectively used for detecting spoilage in meat products as a highly sensitive freshness indicator.

A new photoacoustic method to study diffusion in soft matter

We describe an improvement to the photoacoustic method for determining diffusion coefficients of dyes in soft matter, such as agar hydrogels. The proposed method is based on the properties of thermal wave formed due to a heat transfer at the interface of the two media: the gel and polyethylene film. It is inherently simple, requires a small number of reagents and relatively fast, since samples are small. To assess the obtained results, we independently determined diffusion coefficients of the dyes using an optical image analysis method and found both sets of results to be in a good agreement.

AI-assisted smartphone-based colorimetric biosensor for visualized, rapid and sensitive detection of pathogenic bacteria

Accurate and effective detection is essential to against bacterial infection and contamination. Novel biosensors, which detect bacterial bioproducts and convert them into measurable signals, are attracting attention. We developed an artificial intelligence (AI)-assisted smartphone-based colorimetric biosensor for the visualized, rapid, sensitive detection of pathogenic bacteria by measuring the bacteria secreted hyaluronidase (HAase). The biosensor consists of the chlorophenol red-β-D-galactopyranoside (CPRG)-loaded hyaluronic acid (HA) hydrogel as the bioreactor and the β-galactosidase (β-gal)-loaded agar hydrogel as the signal generator. The HAase degrades the bioreactor and subsequently determines the release of CPRG, which could further react with β-gal to generate signal colors. The self-developed YOLOv5 algorithm was utilized to analyze the signal colors acquired by smartphone. The biosensor can provide a report within 60 min with an ultra-low limit of detection (LoD) of 10 CFU/mL and differentiate between gram-positive (G+) and gram-negative (G-) bacteria. The proposed biosensor was successfully applied in various areas, especially the evaluation of infections in clinical samples with 100% sensitivity. We believe the designed biosensor has the potential to represent a new paradigm of “ASSURED” bacterial detection, applicable for broad biomedical uses.

Agar and Chitosan Hydrogels' Design for Metal-Uptaking Treatments.

In the field of cultural heritage, the use of natural gels is rising for the application of active agents. Here, two natural polymers are assessed: agar, a pioneer hydrogel for conservation treatments, and chitosan, a rather novel and metal-binding gel. For chitosan, a state-of-the-art based formulation (CS-ItA-LCys) is evaluated as it was reported for silver-complexing properties. It is evaluated whether these polymers can withstand the addition of the chelating compound deferoxamine, which is a bacterial siderophore. This allows for the obtainment of completely bio-sourced gel systems. A Fourier-transformed (FT) infrared spectroscopy characterization is performed, completed with rheological measurements and Cryo-Scanning Electron Microscopy (cryo-SEM) to investigate the physico-chemical properties of the gels, as well as their interaction with deferoxamine. Both polymers are also tested for their inherent complexing ability on silver ions using FT-Raman spectroscopy. A multi-analytical comparison shows different microstructures, in particular, the presence of a thick membrane for chitosan and different mechanical behaviors, with agar being more brittle. Neither hydrogel seems affected by the addition of deferoxamine; this is shown by similar rheological behavior and molecular structures in the presence or absence of the chelator. The intrinsic abilities of the chitosan formulation to make silver complex are demonstrated with the observation of two peaks characteristic of Ag-S and Ag-O bonds. Agar and chitosan are both proven to be reliable gels to act as carriers for bio-based active agents. This paper confirms the potential asset of the chitosan formulation CS-ItA-LCys as a promising gel for the complexation of soluble silver.

Agar as a single organogelator in the process of solidification of rapeseed (canola) oil obtained by different manufacturing methods

The minimalistic solidified form of oil, herein called hydroleogel, was elaborated via the emulsion oleogelation method by using agar hydrogel, as sole oleogelator. The rapeseed oils, originating from different manufacturing processes, were used as oil phase. The texture and rheological characteristics, weight loss, oil binding capacity, as well as color and appearance once solidified and after 24 h and 48 h of storage were studied. Texture profile revealed the dual dependance – the hardest hydroleogels were formed with 3 % agar and using refined rapeseed (canola) oil showing 14.16 ± 0.28 N and 14.11 ± 0.45 N after 2 h and 48 h, respectively. In contrast, hydrogels formed with cold pressed oil and 3% agar solution had an average of 50% lower hardness compared to the others. The oil retention capacity of the matrix was highest for hydroleogels with 3 % agar and cold pressed oil (98.3 ± 1.4 %), followed by cold pressed and bleached oil (97.0 ± 1.8 %) and refined oil (95.77 ± 2.4 %). The largest weight losses were observed for hydroleogels based on 1 % agar, with the exception of those formed from refined oil where a sub-weight loss of 0.5 % was recorded after 48h. The brightest were hydroleogels with pressed and bleached oil and 1 % (w/w) agar having after 2h the L* parameter equal to 98.95 ± 0.01, while the darkest one was cold pressed and bleached oil with 3 % (w/w) of agar (83.15 ± 0.25). The concentration of agar and the type of rapeseed oils used strongly impacted the physicochemical parameters of agar-based hydroleogels. Rapeseed oil hydroleogels with agar as the only structuring agent - an oleogelator in the composition, are a unique combination of two phases being hydrogel (aqueous phase) and rapeseed oil (oil phase) with promising physicochemical parameters.

Combined experimental and DFT study on the adsorption of congo red dye using self-assembled hierarchical microspheres of lanthanum hydroxide

Self-assembled hierarchical microspheres of lanthanum hydroxide (La(OH)3) were used to investigate the adsorption of the azo-dye Congo Red (C.R.) in an aqueous medium. The versatile coordination chemistry of lanthanum ions makes them very efficient in adsorption processes involving organic ligands. The microspheres were synthesized using the reaction-diffusion framework (RDF) at ambient temperature, which consists of diffusing a concentrated ammonia solution onto an agar hydrogel matrix containing the dissolved lanthanum salt. The microspheres, which emerged with distinct Liesegang bands ranging in size from ∼300 nm to ∼70 µm, demonstrated rapid adsorption, reaching equilibrium within 15 min, with optimal adsorption of 395 mg g–1 at pH 6 and 30 °C. The kinetic and thermodynamic data were analyzed and fitted to a pseudo-second-order equation and the Sips model. The adsorption mechanism, driven by the dye's structure, the adsorbent's surface chemistry, and the medium, involves complex interplays of electrostatic attractions, physisorption, and chemisorption, with water playing a pivotal role. The positive enthalpy of adsorption extracted from a Sips isotherm, diverging from Langmuir behavior, and FTIR spectral comparisons pre- and post-adsorption provide empirical insights. Density functional theory (DFT) calculations, complemented by implicit solvation models, reveal significant solvation effects on the adsorption enthalpy of the sulfonate group of C.R. on the La(OH)3 surface, highlighting the solvent's vital role. The adsorption enthalpy of +62.63 kJ mol–1 closely aligns with the primary termination of the lanthanum hydroxide surface by water molecules. Remarkably, the bond length between the surface lanthanum and water's oxygen undergoes a significant shift when bonded to the sulfonate group. This study offers a deeper understanding of C.R. dye adsorption dynamics, emphasizing both experimental findings and theoretical insights, underscoring the complex interplay of forces and the central role of water in the process.

A wearable zinc-air battery based on an Agar hydrogel electrolyte for stable operation at −30 °C

Conventional flexible zinc-air batteries (ZABs) electrolytes are mainly made of hydrogels, and thus can freeze at low temperatures and cause cell failure. Here, we report a gel electrolyte consisting of agar, polyacrylamide and dimethyl sulfoxide with high ionic conductivity (24 mS cm−1) at −30 °C. The flexible ZABs based on this gel electrolyte showed good cycling stability (45 h) at −30 °C, which provides a new idea for the development of low-temperature resistant flexible ZABs.

Modification of mechanical, rheological and structural properties of agar hydrogel using xanthan and locust bean gum

Agar is a valuable seaweed hydrocolloid that can form a high-firmness thermoreversible gel. With the increasing demand for vegetarian meals, agar can be used as a gelatin substitute with some modifications. In this study, we investigated the structural, mechanical, and rheological properties of a compound hydrogel using the agar/locust bean/xanthan gum (ALX). The different concentrations of hydrocolloids were optimized based on comparing the results of texture profile analysis of samples with high-bloom gelatin. Fourier transform infrared spectroscopy, differential scanning calorimetry and scanning electron microscopy tests confirmed the interaction between agar, locust bean and xanthan gum. The textural analysis results showed that the addition of locust bean gum (LBG) and xanthan gum (XG) to agar could significantly increase the springiness of agar hydrogel (AG) from 0.92 ± 0.00 to 1.00 ± 0.00, also decrease its hardness from 702.11 ± 5.99 to 343.31 ± 20.23 g (p < 0.05). Moreover, a remarkable decrease was shown in the syneresis degree of AG from 2.33 ± 0.02% to 0.52 ± 0.00%. All behaviors of the optimum hydrogel indicated the effective interaction of LBG and XG with AG which made the final compound hydrogel a promising alternative to high-bloom gelatin.

Evaluation of advective solute infiltration into porous media by pulsed focused ultrasound-induced acoustic streaming effects.

Acoustic streaming induced by applying transcranial focused ultrasound (FUS) promotes localized advective solute transport in the brain and has recently garnered research interest for drug delivery and enhancement of brain waste clearance. The acoustic streaming behavior in brain tissue is difficult to model numerically and thus warrants an in vitro examination of the effects of using different sonication parameters, in terms of frequency, intensity, and pulse duration (PD). Melamine and polyvinyl alcohol (PVA) foams were used to mimic the porous brain tissue, which contains leptomeningeal fenestrations and perivascular space, while agar hydrogel was used to emulate denser neuropil. FUS was delivered to these media, which were immersed in a phosphate-buffered saline containing toluidine blue O dye, across various frequencies (400, 500, and 600 kHz; applicable to transcranial delivery) in a pulsed mode at two different spatialpeak pulse-average intensities (3 and 4 W/cm2). Image analysis showed that the use of 400 kHz yielded the greatest dye infiltration in melamine foam, while sonication had no impact on infiltration in the agar hydrogel due to the dominance of diffusional transport. Using a fixed spatial-peak temporal-average intensity of 0.4 W/cm2 at 400 kHz, a PD of 75 ms resulted in the greatest infiltration depth in both melamine and PVA foams among the tested range (50-150 ms). These findings suggest the existence of a specific frequency and PD that induce greater enhancement of solute/fluid movement, which may contribute to eventual in vivo applications in promoting waste clearance from the brain.

Ionic liquids (ILs)-loaded hydrogels as a potential cleaning method of metallic stains for stone conservation

In the field of built heritage, the removal of reddish-brown and greenish stains presents a complex challenge frequently encountered by experts. Consequently, numerous studies strive to develop sustainable and respectful cleaning methods for conserving stone materials in their original esthetic state. In pursuit of this objective, agar hydrogels were here investigated as solid support, capitalizing on their slow-release capability and capacity to store chemical species. As chelating and biocidal loading, three different ionic liquids (ILs) (trihexyltetradecylphosphonium chloride (TP), bis(2-ethylhexyl) phosphate (BP), and Alicy (AL) and a mixture of Aliquat 336 and Cyanex 272 were tested for the controlled removal of iron and copper stains. The homogeneity and cleaning effectiveness of the different loaded agar hydrogels were assessed on artificial stains using a combination of micro-energy dispersive X-ray fluorescence (µ-ED-XRF) and Raman imaging analyses. The spectroscopic data were supported by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and colorimetric measurements. Additionally, the inhibitory effect on microbial growth of the most effective treatments was tested prior to their in situ application on naturally stained stones. The results indicated that agar provides suitable solid support to apply ILs, specifically highlighting the strong affinity of AL and BP for sequestering iron and copper ions, respectively, from stained stone surfaces. Furthermore, the disk-diffusion results evidenced that the proposed treatments could play a bi-functional role if a biocidal action is required to remove biological colonization, reaching nwhalo average values in the range of 0.6 - 0.8 against Micrococcus Luteus. Thus, this study showcases the potential of agar hydrogels loaded with ILs as a sustainable and gentle cleaning method in built heritage conservation.

Exploring alternative red seaweed species for the production of agar-based hydrogels for food applications

Three different red seaweed species, Gelidium corneum and two Gracilaria species (Agarophyton chilensis, and Gracilariopsis longissima), were used to produce agar-based fractions through conventional and simplified extraction methods and their composition and gel-forming properties were evaluated. The use of an alkaline pre-treatment was effective in removing impurities such as proteins, lipids, and ash, while the agarose/agaropectin ratio in agar was not affected. This led to the formation of hydrogels with higher stiffness and strength. Surprisingly, the presence of semi-crystalline agaropectin in the agar fractions from the two Gracilaria species, especially G. longissima, promoted the formation of more densely packed and stronger hydrogel networks, with higher gelling temperatures and superior mechanical properties. Thus, these results suggest that G. longissima has the potential to be used as an alternative to the more widespread use of G. corneum for the production of agar hydrogels for food applications.

Physiological adaptation in flagellar architecture improves Vibrio alginolyticus chemotaxis in complex environments

Bacteria navigate natural habitats with a wide range of mechanical properties, from the ocean to the digestive tract and soil, by rotating helical flagella like propellers. Species differ in the number, position, and shape of their flagella, but the adaptive value of these flagellar architectures is unclear. Many species traverse multiple types of environments, such as pathogens inside and outside a host. We investigate the hypothesis that flagellar architectures mediate environment-specific benefits in the marine pathogen Vibrio alginolyticus which exhibits physiological adaptation to the mechanical environment. In addition to its single polar flagellum, the bacterium produces lateral flagella in environments that differ mechanically from water. These are known to facilitate surface motility and attachment. We use high-throughput 3D bacterial tracking to quantify chemotactic performance of both flagellar architectures in three archetypes of mechanical environments relevant to the bacterium's native habitats: water, polymer solutions, and hydrogels. We reveal that lateral flagella impede chemotaxis in water by lowering the swimming speed but improve chemotaxis in both types of complex environments. Statistical trajectory analysis reveals two distinct underlying behavioral mechanisms: In viscous solutions of the polymer PVP K90, lateral flagella increase the swimming speed. In agar hydrogels, lateral flagella improve overall chemotactic performance, despite lowering the swimming speed, by preventing trapping in pores. Our findings show that lateral flagella are multipurpose tools with a wide range of applications beyond surfaces. They implicate flagellar architecture as a mediator of environment-specific benefits and point to a rich space of bacterial navigation behaviors in complex environments.

Thermogravimetric analysis of agar hydrogels in combination with honey and sesame flour for the product

An important factor in the stability and quality of gels during production, storage and use as part of confectionery and culinary products is their heat resistance, which depends on the ingredient composition and the content of dry substances. The article is devoted to the thermogravimetric analysis of agar-based hydrogels in combination with honey and sesame flour for the production of bars. The study consisted of two stages. At the first, experimental samples were studied - individual ingredients of the finished hydrogel: agar 1200 TM "Fujian Province" (China), food glycerin TM BASF (Germany), sunflower honey and sesame flour TM "Useful flour" (Ukraine). At the second stage, samples of agar hydrogels were prepared with the required amount of auxiliary ingredients: "agar 1%-water-glycerol 0.2%", "agar 1%-water-glycerol 0.2%-honey 25%", "agar 1%- water-glycerin 0.2%-honey 25%-sesame flour 20%".The comparative analysis of the curves showed that at all stages of decomposition of the experimental samples, mass losses occur due to water evaporation. It was investigated that the final mass loss for pure agar from the beginning of the experiment was 16.91% (16.75 mg), the change in the mass of glycerin was 0.17% (0.21 mg), the mass loss of sunflower honey was 46.06% ( 56.20 mg.), and for sesame flour, the mass change was 7.25% (8.92 mg). However, in complex gels, there was a decrease in the rate of water removal, which is associated with the appearance of additional bonds between agar and recipe components - honey and sesame flour. It was established that at the end of the experiment, the mass of the test sample, namely "agar-water-glycerin", changed by 42% (44.10 mg), the mass loss of the "agar-water-glycerin-sunflower honey" sample was 33.40% ( 36.74 mg.), the mass of the sample "agar-water-glycerin-sunflower honey-sesame flour" gradually decreased and at the end of the experiment changed by 28.82% (34.59 mg) at the temperature, which is associated with the evaporation of water phases. Key words: thermogravimetric analysis, derivatograms, agar, honey, glycerin, sesame flour, hydrogels.

In vivo tests of a novel wound dressing based on agar aerogel

Aerogels, especially bio-based ones, present a promising option for wound dressing; specifically, because of their low toxicity, high stability, bio-compatibility, and good biological performance. In this study, agar aerogel was prepared and evaluated as novel wound dressing material in an in vivo rat study. Agar hydrogel was prepared by thermal gelation, after that the water inside the gel was exchanged with ethanol, and finally the alcogel was dried by supercritical CO2. The textural and rheological properties of the prepared aerogel were characterized, showing that the prepared agar aerogels possess high porosity (97–98 %), high surface area (250–330 m2g−1) as well as good mechanical properties and easiness of removal from the wound site. The results of the in vivo experiments macroscopically demonstrate the tissue compatibility of the aerogels in dorsal interscapular injured rat tissue and a shorter wound healing time comparable to that of gauze-treated animals. The histological analysis underpins the reorganisation and healing of the tissue for the injured skin of rats treated with agar aerogel wound dressing within the studied time frame.

Advances in galvanic corrosion of aluminum alloys

Two lightweight materials were evaluated: a wrought aluminum alloy (AA1) and a cast aluminum alloy (AA2), always coupled to a low-carbon steel (CS). Both the electric potential and pH distributions, of two bare systems (CS-AA1 and CS-AA2) subjected to full immersion conditions in 0.06 M NaCl, are discussed in detail from the experimental and numerical point of views. In conjunction with a miniaturized electrochemical cell and a LAQUAtwin® sensor that allows pH measurements of viscous liquids, solids, and even powder samples, agar hydrogels were used to gather new transient information used to validate a tertiary current distribution model, which was solved by using the finite element method (FEM). The numerical predictions perfectly match with the experimental distributions. The two experimental methodologies exhibit excellent performance for studying galvanic corrosion phenomena, providing reliable and precise results.

Design of vitamin-loaded emulsions in agar hydrogel matrix dispersed with plant surfactants

Polysaccharide colloids and gels supplemented with bioactive compounds are very common in the food industry, although hydrophobic substances can significantly affect the structure and physicochemical properties of hydrogels. In the present study, the impact of natural surfactants, saponins, on agar hydrogels containing vitamins A and E was evaluated. The study started with the research of droplet size distribution of vitamin-loaded aqueous emulsions, stabilized by saponins. A composition containing vitamins at a concentration of 2 mg mL−1 and Sapindus mukorossi saponins at a concentration of 0.1 mg mL−1 was used for further analysis. The second stage of our studies includes the introduction of the emulsion into a hydrogel matrix based on agar. The vitamin-containing hydrogel systems obtained were studied to verify how the vitamin, saponin, and agar concentration affect the mechanical and swelling properties of the materials, as well as their color and transparency. An important aspect was to indicate how the presence of vitamins affects the activity of water molecules measured by low-field NMR. The collected results indicated that, as a result of the use of saponins, stable emulsions that can be incorporated into hydrogels can be obtained while the size and properties of the droplets are maintained without changing their physicochemical properties.

Smart composite hydrogel with magnetocaloric anisotropy for controllable multi-drug release

Controllable multi-drug release has been achieved by constructing a unique composite hydrogel structure comprising two layers of agar hydrogel, each incorporated with magnetically aligned anisotropic Fe3O4 nanorods. With the orthogonal alignment of the Fe3O4 nanorods chains in the two layers, controllable multi-drug release can be triggered by the magnetocaloric anisotropy in different layers of the composite hydrogel, depending on the direction of the external alternating magnetic field. The thermal-triggered release of methylene blue (MB) increases up to 1.4 folds by switching magnetic field direction from 0° to 90°. The physical origin of magnetocaloric anisotropy is magnetic anisotropy. The as-designed composite hydrogel displays an obvious opposite drug release trend by switching the magnetic field direction from 0° to 90°. This opposite drug release trend maintains significantly after more than 4 times of magnetic field direction switching. This work opens a promising avenue for realizing the combination of magnetic hyperthermia and remotely controllable multi-drug combination therapy.

Systematic evaluation of agarose- and agar-based bioinks for extrusion-based bioprinting of enzymatically active hydrogels.

Extrusion-based 3D bioprinting enables the production of customized hydrogel structures that can be employed in flow reactors when printing with enzyme-containing inks. The present study compares inks based on either low-melt agarose or agar at different concentrations (3-6%) and loaded with the thermostable enzyme esterase 2 from the thermophilic organism Alicyclobacillus acidocaldarius (AaEst2) with regard to their suitability for the fabrication of such enzymatically active hydrogels. A customized printer setup including a heatable nozzle and a cooled substrate was established to allow for clean and reproducible prints. The inks and printed hydrogel samples were characterized using rheological measurements and compression tests. All inks were found to be sufficiently printable to create lattices without overhangs, but printing quality was strongly enhanced at 4.5% polymer or more. The produced hydrogels were characterized regarding mechanical strength and diffusibility. For both properties, a strong correlation with polymer concentration was observed with highly concentrated hydrogels being more stable and less diffusible. Agar hydrogels were found to be more stable and show higher diffusion rates than comparable agarose hydrogels. Enzyme leaching was identified as a major drawback of agar hydrogels, while hardly any leaching from agarose hydrogels was detected. The poor ability of agar hydrogels to permanently immobilize enzymes indicates their limited suitability for their employment in perfused biocatalytic reactors. Batch-based activity assays showed that the enzymatic activity of agar hydrogels was roughly twice as high as the activity of agarose hydrogels which was mostly attributed to the increased amount of enzyme leaching. Agarose bioinks with at least 4.5% polymer were identified as the most suitable of the investigated inks for the printing of biocatalytic reactors with AaEst2. Drawbacks of these inks are limited mechanical and thermal stability, not allowing the operation of a reactor at the optimum temperature of AaEst2 which is above the melting point of the employed low-melt agarose.

Tension‐Responsive Graphene Oxide Conductive Hydrogel with Robust Mechanical Properties and High Sensitivity for Human Motion Monitoring

PVA‐BB/GO‐Fe3+/agar hydrogels (BB is configured by 1:1 configuration of 0.04 mol L−1 boric acid solution and 0.04 mol L−1 borax solution) are designed with excellent mechanical and electrical properties due to their triple cross‐linked network, and they maintain stable performance in various tests, which is sufficient to support the use of hydrogels in multiple scenarios. Meanwhile, the tension responsiveness of the PVA‐BB/GO‐Fe3+/agar hydrogel allows it to rapidly transmit signal changes upon tension changes. Finally, maintaining increased energy dissipation and strength enhancement during the loading–unloading cycle provides the possibility of long, stable operation. In summary, it is believed that PVA‐BB/GO‐Fe3+/agar hydrogel has significant potential in the field of flexible sensors and is expected to be fabricated as a sensor for motion monitoring.