A short overview of African horse sickness disease was given. Results were described of a research project that was carried out in Egypt cooperatively between Egyptian and American scientists. The virus was isolated from the blood of street dogs and camels from southern Egypt close to the Sudan border. Camel tick Hyaloma dromadarrii and dog tick Rhipicephalus sanguineus sanguineus harbored and transmitted the virus. Optimal reaction times were determined for agar diffusion precipitin and direct fluorescent antibody tests. Complement fixation and agar precipitin diffusion do not differentiate virus serotypes. Formalin, acetylethyleneimine, and binary ethyleneimine respectively inactivated the virus. Inactive preparation with adjuvant are promising vaccines. The virus was inactivated by irradiation. Plant antiviral extracts were investigated. Latent AHS virus in dogs was activated, producing viremia incident to the dogs being bitten by Culicoides . An antimoulting insecticide was more effective on early developmental stages of Culicoides pipiens .