To examine racial and ethnic differences in cognition and motor skills post-stroke in Asian and Black patients at admission and discharge. Participants were Asian (N = 5659), Black (N = 51,909), and non-Asian/non-Black stroke patients (N = 174,679) admitted to inpatient rehabilitation facilities across the United States. Patient functionality was assessed via the Functional Independence Measure (FIM). Age at admission, admission year, sex, marital status, insurance type, and length of stay were included as covariates. Hierarchical linear regression analyses showed that at admission, Asian and African American stroke patients were associated with reduced cognitive and motor functioning compared to non-Asian/non-Black stroke patients (β's ranged from = -0.020 to -0.032 for both groups; all p's < 0.001). Upon discharge, Asian and Black stroke patients were associated with lower cognitive and motor functioning compared to non-Asian/non-Black stroke patients (β's ranged from = -0.012 to -0.052) for both groups; all p's < 0.001). In an inpatient sample of stroke patients, findings showed race/ethnicity was associated with lower cognitive and motor functioning across at admission and discharge. These data may provide evidence on the role of social determinants of stroke health (Skolarus, 2020) for Asian and Black patients in the inpatient rehabilitation context. Implications for the assessment and practice of Clinical Neuropsychologists working in these settings with Asian and Black stroke patients are discussed.