Aerospace products undergo frequent modifications throughout their product life cycle due to changes in requirements, technology, policy or environmental concerns. These modifications/changes are dealt with through configuration management (CM), which is a techno-managerial function. Conflicting interests of teams involved, complexity due to a long product life cycle spanning over years, R&D nature and techno-political compromises often end up in sub-optimal decisions during aerospace product development. In this article, an attempt is made to apply a scientific method to CM decision-making rather than leave it to techno-political compromises. The CM decision-making is modelled as a multi-criteria decision-making (MCDM) problem and is solved using analytic hierarchy process (AHP). As an example, the CM change proposal on propellant tank material in aerospace is taken up and solved using the model. The authors believe that results of the study will also pave way for substitute development with improved attributes, realized through advances in technologies such as nanotechnology and additive manufacturing, as mentioned in directions for future research.