Aerosol Spray Research Articles

FDA warns against use of Skin-Cap aerosol spray due to undisclosed steroid

FDA warns against use of Skin-Cap aerosol spray due to undisclosed steroid

Improvement of aerosol spray scavenging efficiency by pre-injecting electrically charged water mist

Efficient aerosol scavenging is crucial for gas purification to reduce environmental pollution in various chemical industries. In nuclear reactor decommissioning, especially for damaged reactors after severe accidents like Fukushima Daiichi, controlling radioactive aerosol generation and dispersion is essential. Radioactive aerosols sizing from 0.1 to 1 μm are expected during containment cleaning and fuel debris retrieval processes. To ensure safe decommissioning and mitigate environmental radioactivity, a containment water spray system is used for aerosol scavenging. However, conventional water spray has low efficiency for these submicron aerosols. Our recent experiments at UTARTS demonstrated that pre-injection of water mist enhances scavenging efficacy by increasing aerosol size and hydrophilicity through aerosol-mist agglomeration prior to spraying. On this basis, in this study, we introduced an innovative method using electrically charged water mist, which significantly facilitates aerosol-mist agglomeration through additional electrostatic coagulation, further improving scavenging efficacy (maximum 35 % in current configurations). The present experimental results attained under various mist conditions and charging configurations provided insights into optimizing the mist charging system. Our developed technology is expected to be useful in radioactive aerosol control during damaged reactor decommissioning and has potential applications in other environmental chemical engineering processes.

Response to Comments on “Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray” by Mansuri et al.

Response to Comments on “Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray” by Mansuri et al.

Comments on “Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray” by Mansuri et al.

Comments on “Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray” by Mansuri et al.

Synthesis Pathway of Layered-Oxide Cathode Materials for Lithium-Ion Batteries by Spray Pyrolysis.

We report the synthesis of LiCoO2 (LCO) cathode materials for lithium-ion batteries via aerosol spray pyrolysis, focusing on the effect of synthesis temperatures from 600 to 1000 °C on the materials' structural and morphological features. Utilizing both nitrate and acetate metal precursors, we conducted a comprehensive analysis of material properties through X-ray diffraction (XRD), Raman spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Our findings reveal enhanced crystallinity and significant oxide decomposition within the examined temperature range. Morphologically, nitrate-derived particles exhibited hollow, spherical shapes, whereas acetate-derived particles were irregular. Guided by high-temperature X-ray diffraction (HT-XRD) data, the formation of a layered LCO oxide structure, with distinct spinel Li2Co2O4 and layered oxide LCO phases was shown to emerge at different annealing temperatures. Optimally annealed particles showcased well-defined layered structures, translating to high electrochemical performance. Specifically, nitrate-based particles annealed at 775 °C for 1 h demonstrated initial discharge capacities close to 179 mAh/g, while acetate-based particles, annealed at 750 °C for 3 h, achieved 136 mAh/g at a 0.1C discharge rate. This study elucidates the influence of synthesis conditions on LCO cathode material properties, offering insights that advance high throughput processes for lithium-ion battery materials synthesis.

Acoustic levitation combined with laboratory-based small-angle X-ray scattering (SAXS) to probe changes in crystallinity and molecular organisation.

Single particle levitation techniques allow us to probe samples in a contactless way, negating the effect that surfaces could have on processes such as crystallisation and phase transitions. Small-angle X-ray scattering (SAXS) is a common method characterising the nanoscale order in aggregates such as colloidal, crystalline and liquid crystalline systems. Here, we present a laboratory-based small-angle X-ray scattering (SAXS) setup combined with acoustic levitation. The capability of this technique is highlighted and compared with synchrotron-based levitation-SAXS and X-ray diffraction. We were able to follow the deliquescence and crystallisation of sucrose, a commonly used compound for the study of viscous atmospheric aerosols. The observed increased rate of the deliquescence-crystallisation transitions on repeated cycling could suggest the formation of a glassy sucrose phase. We also followed a reversible phase transition in an oleic acid-based lyotropic liquid crystal system under controlled humidity changes. Our results demonstrate that the coupling of acoustic levitation with an offline SAXS instrument is feasible, and that the time resolution and data quality are sufficient to draw physically meaningful conclusions. There is a wide range of potential applications including topics such as atmospheric aerosol chemistry, materials science, crystallisation and aerosol spray drying.

Abstract 491: Aerosol delivery of immunotherapy and hesperetin nanoparticles in murine lung cancer model

Abstract Purpose: Radiation is the most common modality for lung cancer treatment method. Radiationinduces apoptosis, causing cancer cells to be fragmented and expose the cancer-associatedantigens to the tumor microenvironment. These can be recognized by antigen-presenting cells(APC) to induce the antineoplastic effect by activating cytotoxic T cells. Our prior studies showadding immunoadjuvant like AntiCD40 with radiation can further activate the APCs in its anti-tumor (M1) format. Recent studies have shown that flavonoids like Hesperetin, an ACE2receptor agonist also can induce apoptosis in cancer cells whereas ACE2 receptors are abundant in lung cancer cells.This project aims to develop a novel treatment for non-small cell lung cancer (NSCLC) using nanotechnology for inhalation drug delivery Hesperetin, a flavonoid with antioxidant and pro-apoptotic activity; bound to PLGA-coated nanoparticles (Hesperetin Nanoparticles, HNPs) andAntiCD40 aiming for localized targeted dosing to reduce the treatment-related systemic toxicity.We plan to test the efficacy and safety of this aerosol spray. Methods: In-vitro studies were performed in human A549 (ATCC) and murine LLC1 (ATCC)lung cancer cell lines for growth (MTT) and clonogenic survival assays to demonstrate the anti-cancer cell activity of Hesperetin (Sigma). Next, HNP was prepared using NanoFabTx™ nano-formulation reagent kits (Millipore-Sigma). A syngeneic orthotopic murine model of Lungadenoma was generated in wild (+/+) C57/BL6 background mice with similar background LLC1cell lines. We developed syngeneic orthotopic murine lung tumors with luciferase genetransfected LL/2-Luc2 (ATCC) Lewis Lung Cancer cell line in wild-type C57BL/6 mice(Techonic). Lung tumor-bearing mice were treated with HNP, antiCD40, or both with aerosolspray with a control group treated with the solvent (dH2O) only. To assess the drug delivery withaerosol treatment ex-vivo lung tissue was analyzed for Fluorescence tagged antiCD40 andnanoparticle uptakes. A survival assay was performed to analyze the efficacy of aerosoltreatment of HNPs with or without AntiCD40. All cohorts were also analyzed for body score, body weight, and liver and kidney functions. Results: We were able to successfully develop an aerosol drug delivery model to administer bothAnti-CD40 and HNP in a murine lung cancer model. In our analysis of an orthotopic murinelung cancer model, we demonstrate a high intake of the HNP and AntiCD40 by the cancer cellssparing the normal lung tissue. Moreover, the highest percentage of survival rate was observed with the combination aerosol treatment with HNP+AntiCD40 (p<0.001), compared to CD40alone (p<0.01) or HNP (p<0.01) alone. Comments: This treatment model will allow us to make the lung cancer treatment method easilyavailable for the mass population without having hazardous radiation treatment in the lungcancer model. Citation Format: Sayeda Yasmin-Karim, Geraud Richard, Amanda Fam, Alina-Marissa Ogurek, G. Mike Makrigiorgos. Aerosol delivery of immunotherapy and hesperetin nanoparticles in murine lung cancer model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 491.

Assessment of the Spraying System Impact at the Preparation Stage of Iron Ore Concentrate Products

Introduction. Harmful components of ore dust, formed during the unloading of products in the preparation of iron ore concentrate (PPIOC) at the mixing stage, cause damage to both workers and equipment. To address this issue, liquid aerosol spraying using nozzles with large diameters (>20 μm) is used. However, this method proves ineffective in capturing fine-dust particles. Therefore, enhancing the efficiency of the dust deposition method through PPIOC dust spraying becomes a pressing challenge. The aim of this study is to investigate the impact of the Dry Fog technology, generating liquid droplets up to 20 μm in size, during the unloading stage of PPIOC at a mining and metallurgical enterprise in the precipitation of suspended fine-dust particles. The primary goal of this research was to assess the effectiveness and potential advantages of applying the Dry Fog technology for dust spraying with subsequent precipitation, as this technology has not been previously applied to PPIOC dust.Materials and Methods. The experiment on the PPIOC dust deposition was conducted in a specially designed laboratory setup. Through physical modeling in the laboratory setup, parameters of the precipitation process were obtained. Subsequently, the results were analyzed to understand the dependence of dust precipitation over time, taking into account the influence of the Dry Fog technology. An experiment program was developed for physical modeling. According to the devised program, dust was uniformly loaded into the interior of the laboratory setup (from the top), distributed in the air stream throughout the volume of the setup by a fan, and an instrument located at the bottom recorded changes in concentration over time. Experiments on dust precipitation were then conducted using liquid spraying (filtered water as the liquid) introduced into the setup through nozzles generating droplets with sizes of 10 and 15 μm, concurrently with the loading of dust into the laboratory setup. The effectiveness of the Dry Fog technology in the deposition of PPIOC dust was determined visually and further analyzed based on a comparison of graphs. The dynamics of changes in the average dust concentrations depending on time was studied both during precipitation without spraying and using the Dry Fog technology. During the experiment, the characteristics of the microclimate inside the laboratory setup (humidity, temperature and air velocity) and the parameters of two nozzles — their operating pressure and the supplied liquid spraying time — were recorded.Results. The comparison of the results showed a reduction in the dust precipitation time by 40 % and 75 % when using nozzles with sizes of 10 μm and 15 μm, respectively.Discussion and Conclusion. The experiment results confirm the effectiveness of the Dry Fog technology for PPIOC dust precipitation during unloading at the mixing stage. Fundamental findings have been obtained, providing a basis for further assessment of the efficiency of dust precipitation with the additional application of pulsating ventilation. In such a combination, an additional 20–25 % increase in precipitation efficiency is anticipated compared to the results presented in this article. The obtained results will support the justification of rational parameters and the implementation of the described method in production to enhance dust precipitation efficiency. Additionally, they will aid in developing a methodology to accelerate the PPIOC dust precipitation using the pulsating ventilation method.

Aerosol Plumes of Inhalers Used in COPD.

The selection of inhaler device is of critical importance in chronic obstructive pulmonary disease (COPD) as the interaction between a patient's inhalation profile and the aerosol characteristics of an inhaler can affect drug delivery and lung deposition. This study assessed the in vitro aerosol characteristics of inhaler devices approved for the treatment of COPD, including a soft mist inhaler (SMI), pressurized metered-dose inhalers (pMDIs), and dry powder inhalers (DPIs). High-speed video recording was used to visualize and measure aerosol velocity and spray duration for nine different inhalers (one SMI, three pMDIs, and five DPIs), each containing dual or triple fixed-dose combinations of long-acting muscarinic receptor antagonists and long-acting β2-agonists, with or without an inhaled corticosteroid. Measurements were taken in triplicate at experimental flow rates of 30, 60, and 90 l/min. Optimal flow rates were defined based on pharmacopoeial testing requirements: 30 l/min for pMDIs and SMIs, and the rate achieving a 4-kPa pressure drop against internal inhaler resistance for DPIs. Comparison of aerosol plumes was based on the experimental flow rates closest to the optimal flow rates. The Respimat SMI had the slowest plume velocity (0.99 m/s) and longest spray duration (1447 ms) compared with pMDIs (velocity: 3.65-5.09 m/s; duration: 227-270 ms) and DPIs (velocity: 1.43-4.60 m/s; duration: 60-757 ms). With increasing flow rates, SMI aerosol duration was unaffected, but velocity increased (maximum 2.63 m/s), pMDI aerosol velocity and duration were unaffected, and DPI aerosol velocity tended to increase, with a more variable impact on duration. Aerosol characteristics (velocity and duration of aerosol plume) vary by inhaler type. Plume velocity was lower and spray duration longer for the SMI compared with pMDIs and DPIs. Increasing experimental flow rate was associated with faster plume velocity for DPIs and the SMI, with no or variable impact on plume duration, whereas pMDI aerosol velocity and duration were unaffected by increasing flow rate.

Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray

Superior Skin Penetration of Diclofenac from Dynapar QPS Plus as Compared to Diclofenac Aerosol Spray

Electrically conductive polymer composites based on elastic fiber

The possibility of obtaining electrically conductive composites by applying carbon suspensions to fibrous materials by aerosol spraying and screen printing, on printing equipment, which ensures high productivity, is shown. A manufacturing technology has been developed and the electromechanical properties of layered fibrous composites based on knitwear and graphite dispersion designed for the manufacture of strain and stress sensors used in "wearable electronics", robotics and medicine have been investigated. In an experimental study, it is shown that the conductive path, that is, the length of the chains of contacting filler particles decreases with tensile deformation due to the growth of microcracks in the material. The electrical resistance of growing microcracks has much higher values than the resistance of deformable piezoresistive material. Cracks can open and close in various ways during bending, torsion, stretching and compression deformation. The electrical conductivity of fibers and filaments significantly depends on the localization of electrically conductive particles on their surface or in volume. The location of the conductive chains on the surface or in the volume of the filaments determines the dependence of the electrical properties of composites on the state of the environment (composition, temperature, humidity). Preliminary studies of filaments with electrically conductive components of various chemical nature (metals, metal salts, carbon in various allotropic forms) show that changes in temperature and humidity significantly affect the resistivity of the conductive fiber. The paper presents data on the effect of temperature and humidity on the electromechanical properties of elastic fiber composites with graphite. When stretched to 15%, the calibration coefficient GF is reduced by 2 times at 100% humidity. The different influence of air temperature in the range of 100C-700C on the deformation and strain sensitivity during cyclic deformation up to 15% and 30% has been established. The presence of two ranges of deformation sensitivity is due to the difference in the mechanisms of elongation of knitwear due to straightening and stretching of threads. Different deformation and strain sensitivity of composites in the ranges of small and significant strains, at different temperatures and humidity of the air, has been established. The strain sensitivity reaches 130, and the strain sensitivity is 12 MPa -1, which is an order of magnitude higher than the stress sensitivity of known polymer composites with various electrically conductive fillers.

Superior single-atom Pt/TiO2 mesoporous microspheres via microdrops-confined pyrolysis/deposition for low-temperature CO oxidation

This work demonstrate a polymer micelle-induced mesoporous single-atom Pt1/TiO2 microspheres with a mixed mother solution of triblock copolymer (Pluronic F127), H2PtCl6 and tetrabutyl titanate (TBT). The specific surface area and pore volume of mesoporous single-atom Pt1/TiO2 microspheres reach 179 m2/g and 0.39 cm3/g, respectively. The synthesis reaction is spatially confined in microdrops via aerosol spray. The obtained catalysts present superior activity for CO oxidation at low temperature. Typically, T100 (Temperature required to reach 100% conversion) of CO conversion (1.0% CO + 1.0% O2) is achieved at 120 °C with 0.5 at% Pt1/TiO2 catalysts, 50–60 °C lower than that with the same Pt loaded non-mesoporous catalysts from conventional photo-deposition and immersion-deposition of Pt on commercial TiO2 nanoparticles. Thus, this work paves a way to access efficient single-atom catalysts for CO oxidation.

Comparison of sampling methods for the determination of volatile organic compounds in consumer aerosol sprays

Many studies have evaluated the hazardous substances contained in various household chemical products. However, for aerosol spray products there is currently no international standard sampling method for use in a component analysis. The aim of this study was to develop an appropriate sampling method for the analysis of volatile organic compounds (VOCs) in consumer aerosol sprays. Two different sampling methods, spraying (into a vial) and perforating (and transferring the contents into a vial), were used to evaluate the levels of 16 VOC components in eight different aerosol spray products. All eight products contained trace amounts of hazardous VOCs, and a quantitative analysis showed that, for the same product, VOC concentrations were higher when spraying than when perforating. Using the spraying method, average toluene, ethylbenzene, p-xylene, o-xylene, and styrene concentrations were 1.80-, 2.10- 2.25-, 2.03-fold, and 1.28-fold higher, respectively, than when using the perforating method. The spraying method may provide more realistic estimates of the user's exposure to harmful substances and the associated health risks when using spray products. Of the two representative methods widely used to analyze harmful substances in consumer aerosol sprays, the spraying method is recommended over the perforating method for the analysis of VOCs.

Eco-enzyme as disinfectant: a systematic literature review

COVID-19 increases the awareness of cleanliness and sanitation in society. Trends in launching sanitizer and disinfectant products have risen significantly to meet customer demand. However, the existing commercial sanitizer products are mostly chemical-based and may cause adverse effects. Therefore, eco- enzyme is a perfect bio-waste utilization for nonchemical-based sanitization products. The authors investigated eco-enzymes' effectiveness in an aerosol spray from fruit waste for a pleasant natural disinfectant. This review aimed to compile results from previous studies on fruit waste by systematically reviewing empirical studies on household waste practices to develop an eco-enzyme following the PRISMA guidelines. A digital search in five databases from Google Scholar, PubMed, Garuda, Sinta, and Open Alex resulted in 24 relevant journals, considering keywords such as eco-enzyme, disinfectant, and organic waste. The mapping results show that eco-enzyme is feasible and economical for disinfecting and sanitizing surfaces due to its antimicrobial activity. The presence of acetic acids and enzymes (i.e., lipases and amylases) can inhibit specific strains of microorganisms, namely <em>Escherichia coli</em> and <em>Enterococcus</em> sp.

Mesoporous silica particles by aerosol spray synthesis; solid core and porous shell structure study

Mesoporous silica core shell particles are materials of high interest especially due to pharmaceutical and catalytic applications. In the current work we presented the synthesis of uniformly porous and solid core porous particles by aerosol spray pyrolysis route according to the principles of EISA, by a one step process. The particles are evaluated morphologically by TEM and by nitrogen adsorption and desorption isotherms for pore size distribution and pore connectivity, validating the effect of synthesis parameters on the core size, surface area and porosity of the uniformly porous and core-shell structures. Three different surfactants Brij-58, CTAB, P123 at various concentrations and combinations as well as three different core type compositions of NaCl, CeO2 and, Ce0.8Zr0.2O2 have been evaluated for the controlled synthesis of silica core-shell particles by a scalable synthesis method.

Two level deacidification mathematical model for the description of transport of solid alkaline particles and diffusion of ions in a treated acid paper

Industrial progress in papermaking in the early nineteenth century led to the technologies that resulted in more acidic papers, which was caused mainly by the exploitation of alum (KAl(SO4)2) and rosin as sizing agents. The papers prepared by such technologies have degraded more quickly. From the 1930s various deacidification and preservation processes with basic agents have been developed. The most widespread deacidification process is with the aerosol (spray system) consisting of microscale particles MgO and perfluoroheptane (PFH) as a carrier (the so-called Bookkeeper process). The shortcomings of this process are the low dissolution of solid MgO particles and the transport to the interior of acidic paper. We have developed a theoretical two-level model of the Bookkeeper process suitable for prediction of deacidification extent. The model involves both the dissolution/reaction of the solid particles and transport of solvated ions and solid particles inside the bulk of paper. The developed model coincides with the results of the performed deacidification experiment. The model is also in good agreement with the Lucas–Washburn equation, which is usually used for the description of the penetration of a deacidifying agent into the paper.

The Use of Sacrificial Graphite-like Coating to Improve Fusion Efficiency of Copper in Selective Laser Melting

Thin and ultrathin carbon films reduce the laser energy required for copper powder fusion in selective laser melting (SLM). The low absorption of infrared (IR) radiation and its excellent thermal conductivity leads to an intricate combination of processing parameters to obtain high-quality printed parts in SLM. Two carbon-based sacrificial thin films were deposited onto copper to facilitate light absorption into the copper substrates. Graphite-like (3.5 µm) and ultra-thin (25 nm) amorphous carbon films were deposited by aerosol spraying and direct current magnetron sputtering, respectively. The melting was analyzed for several IR (1.06 µm) laser powers in order to observe the coating influence on the energy absorption. Scanning electron microscopy showed the topography and cross-section of the thermally affected area, electron backscatter diffraction provided the surface chemical composition of the films, and glow-discharge optical emission spectroscopy (GDOES) allowed the tracking of the in-deep chemical composition of the 3D printed parts using carbon film-covered copper. Ultra-thin films of a few tens of nanometers could reduce fusion energy by about 40%, enhanced by interferences phenomena. Despite the lower energy required, the melting maintained good quality and high wettability when using top carbon coatings. A copper part was SLM printed and associated with 25 nm of carbon deposition between two copper layers. The chemical composition analysis demonstrated that the carbon was intrinsically removed during the fusion process, preserving the high purity of the copper part.

Безопасность использования в практике дезинфицирующих средств на основе гипохлорита натрия

The parameters of toxicometry of disinfectants based on sodium hypochlorite obtained by chlorination of an aqueous solution of caustic soda (31 agents) and by electrochemical method – 10 anoliths were established. Based on the determination of the chlorine content in the air, recommendations are given for the safe use of these disinfectants: for surface treatment by wiping and disinfection of air and surfaces by aerosol spraying using a special device – an aerosol generator that provides dispersion of aerosol particles of 5–50 microns. A working solution of sodium hypochlorite with an active chlorine content of 0.015?% is recommended for use by wiping in the presence of people. Keywords: disinfectants, sodium hypochlorite, anolytes, toxicity, irritant effect, inhalation hazard, aerosol, laboratory animals.

STRUCTURAL ANALYSIS FOR A NANO-CRYSTALLINE FILM (ZnS) BY AEROSOL SPRAY PYROLYSIS TECHNIQUE

Nano thin film materials play an indispensable role in modern electronics and other field of material sciences especially in a photovoltaic technology. The scope of this research is to grow Zinc Sulphide (ZnS) thin film and characterize structurally to understand the benefits of the study choosing chemical deposition method (The aerosol spray pyrolysis), the chemical combination analysis and the annealing temperature. Specifically on the film strength and its applications. In the light of this work, Nano crystalline ZnS thin films was grown by carefully dissolving 1.48g of Zinc Acetate (Zn(CH3CO2)2) in 15ml of a distilled water (H2O), Followed by the deposition of 50, 5, and 30ml of acetone (CH3COCH3), acetic acid (CH3COOH) and ethanol (C2H6O) to the solution respectively, all in molar concentration of 0.1 M per ml. The solution was allowed to spray for 10 minutes on a soda lime glass substrate (SLG) at 300oC. The process was repeated for the sample annealed at 300oC and 400oC under Nitrogen gas (N2) environment for 60 minutes. The X-ray diffraction pattern of all the films deposited shows a cubic crystal type with mean crystallite size in the range 0.35nm as deposited, 0.4179 nm and 0.44nm at 300oC and 400oC annealing temperature respectively. Patterns of the sprayed film after performing the phase analysis reveal peaks corresponding to the (111) planes of reflection, which indicate the suitability of the deposition process and chemical combination. Furthermore, it is also concluded that the strength of the material depends on the annealing and substrate temperature.

Performance of Ni-doped BaTiO3 hollow porous spheres supported reduced graphene oxide as an efficient bifunctional electrocatalyst for oxygen evolution reaction and oxygen reduction reaction

Perovskite oxides are promising and effective electrocatalysts for various energy related applications due to their low cost, versatile structures, as well as interesting catalytic activity. Herein, aerosol spray pyrolysis was used to synthesize hollow spherical structure of BaTiO3, Ni-doped BaTiO3 and Ni-doped BaTiO3 supported on reduced graphene oxide (rGO). The prepared nanocomposites were used as bifunctional electrocatalysts simultaneously for oxygen reduction and oxygen evolution reactions. Several characterization techniques were utilized for characterizing the prepared materials. The morphological analysis revealed that the produced spheres consisted of nanoparticles ranging in size from 5 to 20 nm, while the Brunauer–Emmett–Teller surface analysis assured the high mesoporous features of the prepared hollow spheres. The oxygen evolution reaction (OER) results exhibited an exceptional current density up to 80 mA cm−2 at potential 1.6 V vs. RHE, this performance was five times higher than the pure BaTiO3 (BTO). The Tafel slope was reduced by 75.5 % compared to BaTiO3. Ni-doped BaTiO3/rGO hollow porous spheres show excellent OER electrocatalytic activity compared to the commercial IrO2 electrocatalyst in basic medium. Moreover, the prepared Ni-doped BaTiO3/rGO hollow porous spheres presented excellent catalytic activity for oxygen reduction reaction (ORR), mainly favored a direct four-electron pathway, enhanced the charge transfer, led to the lowest onset potential (0.77 V vs RHE), and also achieved excellent long-term durability. The results demonstrated that the prepared perovskite/rGO composites effective bifunctional electrocatalysts.