VO2max Research Articles

The alteration of LBX1 expression is associated with changes in parameters related to energy metabolism in mice.

The LBX1 gene is located near a single nucleotide polymorphism that is highly associated with susceptibility to adolescent idiopathic scoliosis and is considered one of the strongest candidate genes involved in the pathogenesis of this condition. We have previously found that loss of LBX1 from skeletal muscle results not only in spinal deformity but also in lean body mass, suggesting a potential role for LBX1 in energy metabolism. The purpose of the present study was to test this hypothesis by analyzing the phenotype of mice lacking LBX1 in skeletal muscle with a focus on energy metabolism. We found that loss of LBX1 rendered mice more resistant to high-fat diet-induced obesity, despite comparable food intake between mutant and control mice. Notably, the mutant mice exhibited improved glucose tolerance, increased maximal aerobic capacity, and higher core body temperature compared to control mice. In addition, we found that overexpression of LBX1 decreased glucose uptake in cultured cells. Taken together, our data show that LBX1 functions as a negative regulator of energy metabolism and that loss of LBX1 from skeletal muscle increases systemic energy expenditure resulting in lean body mass. The present study thus suggests a potential association between LBX1 dysfunction and lean body mass in patients with adolescent idiopathic scoliosis.

The Ex-Timing trial: evaluating morning, afternoon, and evening exercise on the circadian clock in individuals with type 2 diabetes and overweight/obesity—a randomized crossover study protocol

BackgroundExercise is known to provide multiple metabolic benefits such as improved insulin sensitivity and glucose control in individuals with type 2 diabetes mellitus (T2DM) and those at risk. Beyond the traditional exercise dose, exercise timing is perceived as a contemporary hot topic, especially in the field of T2DM; however, the number of intervention studies assessing exercise timing and glucose metabolism is scarce. Our aim is to test the effect of exercise timing (i.e., morning, afternoon, or evening) on the inter-individual response variability in glycemic control and related metabolic health parameters in individuals with T2DM and those at risk during a 12-week intervention.MethodsA randomized crossover exercise intervention will be conducted involving two groups: group 1, individuals with T2DM; group 2, age-matched older adults with overweight/obesity. The intervention will consist of three 2-week blocks of supervised post-prandial exercise using high-intensity interval training (HIIT). Between each training block, a 2-week washout period, where participants avoid structured exercise, will take place. Assessments will be conducted in both groups before and after each exercise block. The primary outcomes include the 24-h area under the curve continuous glucose monitoring-based glucose. The secondary outcomes include body composition, resting energy expenditure, insulin response to a meal tolerance test, maximal aerobic capacity, peak power output, physical activity, sleep quality, and insulin and glucose levels. All primary and secondary outcomes will be measured at each assessment point.DiscussionOutcomes from this trial will provide us additional insight into the role of exercise timing on the inter-individual response variability in glycemic control and other related metabolic parameters in two distinct populations, thus contributing to the development of more effective exercise prescription guidelines for individuals with T2DM and those at risk.Trial registrationClinicalTrials.gov NCT06136013. Registered on November 18, 2023.

Yogistic efficacy on cardiopulmonary capacities, endurance efficiencies and musculoskeletal potentialities in female college students.

Physical exercise participation among female students is significantly compromised throughout the academic periods of college or university due to scholastic demands and also by less parental and community encouragements. Thus, physical inactivity in female college students leads to less musculoskeletal efficiency and work performance. Customized yogic module may be considered to enhance both aerobic and anaerobic power, pulmonary capacity and musculoskeletal efficiency for the improvement of systemic body functions among female college students. A randomized, controlled parallel study design (n = 60; age = 20.16±2.05 years), on sedentary female college students practicing customized yogic module (n = 30) for 5 days / week for 3 months (60 min daily in the morning) to observe anthropometric, physiological, cardiopulmonary and muscular endurance indices. After yogic practice, a significant reduction in body fat (p < 0.05) (%), heart rate (p < 0.001), systolic blood pressure (p < 0.001), double product (p‹0.01) and rate pressure product (p < 0.05) were estimated. Significant improvement (p < 0.001) in vital capacity, forced expiratory volume in 1 sec was also observed. Evaluation of hand grip strength, maximal oxygen consumption and physical work capacity showed significant increase (p < 0.01) after yogic intervention. A three-month customized yogic training improved resting physiological activities, cardiopulmonary functions, musculoskeletal strength and endurance fitness due to focused breathing, mindfulness meditation and by stretching-strengthening patterns for achieving recreational physical activity among female college students.

Assessment of oxygen kinetic parameters for closely related ammonia-oxidizing bacteria.

The reaction kinetics of lithotrophic ammonia-oxidizing bacteria (AOB) are strongly dependent on dissolved oxygen (DO) as their metabolism is an aerobic process. In this study, we estimate the kinetic parameters, including the oxygen affinity constant (Km[O2]) and the maximum oxygen consumption rate (Vmax[O2]), of different AOB species, by fitting the data to the Michaelis-Menten equation using non-linear regression analysis. An example for three different species of Nitrosomonas bacteria (N. europaea, N. eutropha, and N. mobilis) in monoculture is given, finding a Km[O2] of 0.25±0.05 mg L-1, 0.47±0.09 mg L-1, and 0.28±0.08 mg L-1, and a Vmax[O2] of 0.07±0.04 pg h-1cell-1, 0.25±0.06 pg h-1cell-1, and 0.02±0.001 pg h-1cell-1 for Nitrosomonas europaea, Nitrosomonas eutropha, and Nitrosomonas mobilis, respectively. This study shows that of the analyzed AOB, N. europaea has the highest affinity towards oxygen and N. eutropha the lowest affinity towards oxygen, indicating that the former can convert ammonia even under low DO conditions. These results improve the understanding of the ecophysiology of ammonia-oxidizing bacteria in the environment. The accuracy of mathematically modelled ammonia oxidation can be improved, allowing the implementation of better management practices to restore the nitrogen cycle in natural and engineered water systems.

Implementation of nutrition care process in Indonesian athletes and its effect on nutritional status and aerobic capacity performance

Introduction: Despite the critical function of a nutritionist, only a few sports training centres for students in Indonesia have one. This study aimed to determine the effect of the nutrition care process (NCP) on athletes’ nutritional status and aerobic capacity performance. Methods: This cohort study was conducted in 2022 (May–August) in four training centres (TC) in Indonesia. Subjects were athletes who have been dwelling in TC for at least three months, excluding those absent for &gt;14 days due to a competition or other commitments during the data collection period. NCP included the assistance of trained sports nutritionists. In total, 114 athletes participated in this study: 90 strength athletes and 24 endurance athletes. The participants were aged 14-19 years old with approximately (mean+SD) 6+2.5 years of experience in specific sports. Results: After three months of NCP, knowledge of nutrition (p=0.013), body fat composition (p&lt;0.001), skinfold thickness scores (p&lt;0.001), and performance (p&lt;0.001) of athletes significantly improved. In spite of good intakes of protein and fat, none of the intakes showed significant changes (p&gt;0.05). Furthermore, improved knowledge of sports nutrition and exercise science had a positive impact on dormitory meal choices. Conclusion: Overall, three months of NCP had a significant effect on athletes’ knowledge of nutrition, body fat composition, skinfold thickness, and also VO2Max.

Trends and Future Directions in the Sports Performance of Deaf and Hard-of-Hearing Athletes: A Systematic Review

The aim of this systematic review was twofold: to identify the main trends and issues that are being addressed by researchers in the context of physical fitness and sports performance in deaf and hard-of-hearing (D/HH) athletes and to indicate the needs and future directions that should be implemented in the training process of athletes with hearing impairments. The methodology of this systematic review was planned according to PRISMA guidelines. A search of electronic databases (PubMed, EBSCO, Scopus) was conducted to identify all studies on physical fitness, sports performance and participation, and D/HH athletes from 2003 to 2024. In total, 87 full-text articles were assessed to determine eligibility, while 34 studies met the inclusion criteria and were subjected to detailed analysis and assessment of their methodological quality. The presented systematic review indicates evidence that D/HH athletes are characterized by a similar or higher level in selected motor abilities compared to hearing athletes. Moreover, it seems that hearing impairment is not a barrier in the development of an athlete’s physical fitness, including aerobic capacity, muscular strength and power or speed of reaction. Furthermore, inclusion in sports participation and specific tools (i.e., communication aids) appear to be crucial factors for performance enhancement.

Effectiveness of maximum, explosive and combined strength training on endurance runners performance indicators: a systematic review and meta-analysis

Objective: This study aimed to analyze the effect of practicing maximum strength (MAX), explosive strength (EXP), or both combined (COMB) on seven runners’ performance indicators: vertical jump (VJ), one-repetition maximum squat (1RM), peak velocity/peak running speed (PV), lactate threshold (LT), middle-distance time trial (TT), maximum oxygen consumption (VO2max), and running economy (RE). Methods: A systematic review (Scopus, Web of Science, Sports Discuss, PubMed) with meta-analysis was conducted following PRISMA standards. Inclusion criteria (PICOS) were: Recreational or well-trained athletes aged 18-45 performing concurrent training for at least five weeks. The search terms used were related to different types of strength/endurance and participants’ age and sports modality. Twenty manuscripts were selected, and quality assessed with PEDro. Results: MAX training is more effective than EXP and COMB in improving VJ, 1RM, and PV, while COMB is more effective than MAX and EXP to enhance TT. MAX is more effective than EXP in improving LT. Concurrent workouts do not provide additional benefits to VO2max. It is unknown which strength modality (MAX, EXP, or COMB) is more effective in improving RE. Conclusion: Concurrent training is more effective than single-mode endurance training for enhancing specific performance variables in adult endurance runners. Middle- and long-distance runners may consider incorporating MAX training to target specific goals (i.e., improving VJ, 1RM, LT, PV) while utilizing COMB training to enhance TT. Certain variables may benefit from EXP. New randomized controlled trials are required to confirm these findings. Keywords: endurance, running, concurrent training, maximum strength, explosive strength

Informativeness of the LDF method in assessing physical performance

In healthy volunteers, physical performance was assessed according to PWC170 tests, maximum oxygen consumption and microcirculation status by laser Doppler flowmetry (LDF) using a computerized LAKK-02 analyzer. The performance indicators corresponded to the norms of the age group, while significant correlations were revealed with the indicators obtained during the LDF, which confirms the informativeness of the method.

The complicated relationship between asthma and swimming

Introduction: Apart from pharmacological treatment, non-pharmacological strategies including physical activity play a significant role in the management of asthma. The aim of this paper is to examine various topics related to swimming and asthma. They include the detailed effect of swimming on asthma control,the potential role of swimming in early childhood asthma development, exercise induced asthma in swimmers as well as the relationship between asthma and cold water swimming. Review methods: This article is based on the literature found in the PubMed Database from the period of 1971-2024 with the use of keywords such as “asthma”, “swimming”, “cold water swimming”, “exercise induced asthma”, “childhood asthma” Description of the state of knowledge: Swimming is a safe form of physical activity for asthma patients.Swimming training enhances aerobic capacity, reduces exercise-induced bronchoconstriction and improves lung function in both pediatric and adult patients. However, there is a concern regarding indoor swimming pools that chlorine can potentially induce airway inflammation. There is research suggesting that early life swimming pool exposure may contribute to the asthma development in atopic children. There is some premise to the thought that cold water swimming may help alleviate asthma symptoms, but it also carries many risks.Swimming is a major cause of exercise induced asthma in professional athletes. Conclusions: Alongside appropriate pharmacological treatment, swimming is a valuable strategy in asthma management in both pediatric and adult asthma patients. The risks of chlorinating pools are still not known to outweigh the benefits of swimming for asthmatics. Further research should be carried out on safety of early swimming in atopic children. Cold water swimming should also be evaluated in terms of safety and potential benefits for asthma patients.

Physiological Responses of Wheelchair Basketball Athletes to a Combined Aerobic and Anaerobic Training Program

Among the multifarious adapted sports, wheelchair basketball stands out as a highly recommended group activity among individuals with paraplegia, including those with Spinal Cord Injury (SCI). Athletes facing this particular impairment exhibit distinct alterations in their metabolic, cardiorespiratory, neuromuscular, and thermoregulatory systems, ultimately leading to a diminished physiological respiratory capacity in comparison to able-bodied individuals or those with other forms of impairments. The primary objective of the present research endeavor is therefore to explore the impact of a comprehensive exercise regime, encompassing both aerobic and anaerobic components, upon the enhancement of the aerobic capacity of wheelchair basketball athletes. A total of 32 wheelchair basketball players, ranging in age from 34 to 42, were enlisted in the study, with half allocated to an experimental group engaging in combined aerobic and anaerobic training [EG, n = 16], while the remaining participants were assigned to a control group undertaking solely aerobic exercise training [CG, n = 16]. The 12-minute wheelchair propulsion distance was utilized to evaluate the V̇O2peak in individuals with paraplegia, both before and after the intervention. The findings revealed a significant Time x Group interaction for the 12-minute wheelchair propulsion distance variable, highlighting a notable enhancement in the treatment group (p &lt; 0.001). In contrast, no substantial changes were detected in the control group. Thus, the outcomes suggest that the integration of aerobic and anaerobic exercise yields a highly positive impact on the aerobic performance of wheelchair basketball players. Key words: physiology; exercise; sport; spinal cord injuries; cardiorespiratory fitness.

Time-course for onset and decay of physiological adaptations in endurance trained athletes undertaking prolonged heat acclimation training

ABSTRACT Short-term heat acclimation (HA) appears adequate for maximizing sudomotor adaptations and enhancing thermal resilience in trained athletes. However, for enhanced erythropoiesis and transfer effects to exercise capacity in cooler environments, prolonged HA appears necessary. To establish the time-course for physiological adaptations and performance effects, 20 male elite cyclists were divided into an intervention group (HEAT; n = 10) completing 5 weeks of HA (six one-hour HA-training sessions per week) and control (n = 10) tested pre and post in hot (40°C) and cool conditions (20°C). HEAT completed tests at 40°C every week during HA with measures of sweat rate and [Na+] and a decay test 2 weeks after termination of HA. HEAT improved time for exhaustion by 15 min (p < 0.001) in the 40°C test, increased sweat rate by 0.44 L/hour (p < 0.001), and lowered sweat sodium concentration [Na+] by 14.1 mmol/L (p = 0.006) from pre- to post-HA, with performance returning to pre-HA levels in the 2-week decay test. Total hemoglobin mass (tHbmass) was increased by 30 grams (+3%, p = 0.048) after 3 weeks and 40 grams (+4%, p = 0.038) after 5 weeks in HEAT but returned to pre-HA levels at the 2-week decay test. HEAT improved incremental peak power output (+12 W, p = 0.001) without significant changes in maximal oxygen uptake (p = 0.094). In conclusion, improvements in heat exercise tolerance and sudomotor adaptations materialized during the first ~3 weeks and the entire 5 weeks of HA augmented both cool exercise capacity and tHbmass. However, the 2-week post-HA evaluation demonstrated a rapid decay of physiological adaptations and exercise capacity in the heat.

Using cardiorespiratory fitness to operationalize vitality: a path analysis on the hierarchical structure of intrinsic capacity

BackgroundThere is a lack of consensus about the operationalization of vitality, which is one of the intrinsic capacity (IC) domains. In particular, no study has investigated whether cardiorespiratory fitness (CRF) can be considered a vitality indicator. ObjectiveTo examine whether vitality is the upstream domain of IC, and establish the validity of CRF as a vitality indicator, using maximal oxygen consumption (VO2 max) as a representative. Methods561 older adults from a longitudinal cohort study were included. Variables under consideration were VO2 max, other IC domains, instrumental activities of daily living (IADL), and handgrip strength, which was considered an already validated indicator of vitality. Using handgrip strength as the reference point, path analyses were performed to examine whether VO2 max followed a similar hierarchical structure in predicting change in IADL difficulty through other IC domains. ResultsThe mean age of the participants was 75.5 years. The path model in which vitality was measured by VO2 max demonstrated adequate fit, which was similar to the model in which vitality was measured by handgrip strength. Regarding the path coefficients, the model using VO2 max demonstrated significant total and indirect effects. Notably, the indirect effect was due to the locomotor domain (standardized coefficient = −0.148, p < .001), but not the cognitive or psychological domain. ConclusionVitality is the upstream domain of IC. VO2 max can be considered an indicator to operationalize the vitality concept.

Heavy-intensity priming exercise extends the V̇o2max plateau and increases peak-power output during ramp-incremental exercise.

This study investigated whether a heavy-intensity priming exercise precisely prescribed within the heavy-intensity domain would lead to a greater peak-power output (POpeak) and a longer maximal oxygen uptake (V̇o2max) plateau. Twelve recreationally active adults participated in this study. Two visits were required: 1) a step-ramp-step test [ramp-incremental (RI) control], and 2) an RI test preceded by a priming exercise within the heavy-intensity domain (RI primed). A piecewise equation was used to quantify the V̇o2 plateau duration (V̇o2plateau-time). The mean response time (MRT) was computed during the RI control condition. The delta (Δ) V̇o2 slope (S; mL·min-1·W-1) and V̇o2-Y intercept (Y; mL·min-1) within the moderate-intensity domain between conditions (RI primed minus RI control) were also assessed using a novel graphical analysis. V̇o2plateau-time (P = 0.001; d = 1.27) and POpeak (P = 0.003; d = 1.08) were all greater in the RI primed. MRT (P < 0.001; d = 2.45) was shorter in the RI primed compared with the RI control. A larger ΔV̇o2plateau-time was correlated with a larger ΔMRT between conditions (r = -0.79; P = 0.002). This study demonstrated that heavy-intensity priming exercise lengthened the V̇o2plateau-time and increased POpeak. The overall faster RI-V̇o2 responses seem to be responsible for the longer V̇o2plateau-time. Specifically, a shorter MRT, but not changes in RI-V̇o2-slopes, was associated with a longer V̇o2plateau-time following priming exercise.NEW & NOTEWORTHY It remains unclear whether priming exercise extends the maximal oxygen uptake (V̇o2max) plateau and increases peak-power output (POpeak) during ramp-incremental (RI) tests. This study demonstrates that a priming exercise, precisely prescribed within the heavy-intensity domain, extends the plateau at V̇o2max and leads to a greater POpeak. Specifically, the extended V̇o2max plateau was associated with accelerated RI-V̇o2 responses.

Longitudinal decline in peak V̇o2 with aging in a healthy population is associated with a reduction in peripheral oxygen utilization but not in cardiac output.

Aging is associated with a significant decline in aerobic capacity assessed by maximal exercise oxygen consumption (V̇o2max). The relative contributions of the specific V̇o2 components driving this decline, namely cardiac output (CO) and arteriovenous oxygen difference (A - V)O2, remain unclear. We examined this issue by analyzing data from 99 community-dwelling participants (baseline age: 21-96 yr old; average follow-up: 12.6 yr old) from the Baltimore Longitudinal Study of Aging, free of clinical cardiovascular disease. V̇o2peak, a surrogate of V̇o2max, was used to assess aerobic capacity during upright cycle ergometry. Peak exercise left ventricular volumes, heart rate, and CO were estimated using repeated gated cardiac blood pool scans. The Fick equation was used to calculate (A - V)O2diff,peak from COpeak and V̇o2peak. In unadjusted models, V̇o2peak, (A - V)O2diff,peak, and COpeak declined longitudinally over time at steady rates with advancing age. In multiple linear regression models adjusting for baseline values and peak workload, however, steeper declines in V̇o2peak and (A - V)O2diff,peak were observed with advanced entry age but not in COpeak. The association between the declines in V̇o2peak and (A - V)O2diff,peak was stronger among those ≥50 yr old compared with their younger counterparts, but the difference between the two age groups did not reach statistical significance. These findings suggest that age-associated impairment of peripheral oxygen utilization during maximal exercise poses a stronger limitation on peak V̇o2 than that of CO. Future studies examining interventions targeting the structure and function of peripheral muscles and their vasculature to mitigate age-associated declines in (A - V)O2diff are warranted.NEW & NOTEWORTHY The age-associated decline in aerobic exercise performance over an average of 13 yr in community-dwelling healthy individuals is more closely associated with decreased peripheral oxygen utilization rather than decreased cardiac output. This association was more evident in older than younger individuals. These findings suggest that future studies with larger samples examine whether these associations vary across the age range and whether the decline in cardiac output plays a greater role earlier in life. In addition, studies focused on determinants of peripheral oxygen uptake by exercising muscle may guide the selection of preventive strategies designed to maintain physical fitness with advancing age.

The combined effect of cardiorespiratory and muscular fitness on the incidence of metabolic syndrome before midlife.

Cardiorespiratory fitness (CRF) could reduce the risk of metabolic syndrome (MetS) while the association between muscular endurance capacity (MEC) and incident MetS has rarely been investigated in young adults. A total of 2890 military men and women, aged 18-39years, free of baseline MetS in Taiwan, were followed for incident MetS from baseline (2014) until the end of 2020. All subjects received annual health examinations for assessment of MetS. Physical fitness was assessed by CRF (estimated maximal oxygen uptake, VO2 max [mL/kg/min], in a 3000-m run) and MEC (numbers of 2-min push-ups). MetS was defined according to the International Diabetes Federation (IDF) criteria. Multiple Cox regression analysis was conducted with adjustments for baseline age, sex, substance use status and physical activity to determine the associations of CRF and MEC with incidences of new-onset MetS and related features, for example, central obesity, hypertension, dyslipidaemia and prediabetes or diabetes. To examine the combined effects of CRF and MEC status on incidence of MetS, high and low levels of CRF and MEC were separately defined by over and under the sex-specific median in each exercise test. During a median follow-up of 5.8years, there were 673 (23.3%) new-onset MetS. Higher CRF was associated with a lower incidence of MetS (hazard ratio [HR] and 95% confidence interval: 0.905 [0.877-0.933]), and its components separately, except hypertension. No association was observed between MEC and incident MetS, and its components separately, except hypertension. When evaluating the combined effects of MEC and CRF status on the incidence of MetS, it was observed that compared with the low CRF/low MEC, the high CRF/high MEC (HR: 0.553 [0.439-0.697]) and the high CRF/low MEC (HR: 0.730 [0.580-0.918]) had a lower incidence of new-onset MetS (P value for the intergroup difference=0.04). There was no significant result for the low CRF/high MEC. This study highlights that although the protective effects of MEC to reduce the incidence of MetS and most of its related features were mainly driven by CRF in young adults, there was an addictive effect of greater MEC on CRF to prevent the development of new-onset MetS before midlife.

Safety and Effectiveness of Selexipag in Pediatric Pulmonary Hypertension: A Retrospective Multi-Center Cohort Study

ObjectiveTo describe the safety and effectiveness of treating pediatric patients who have pulmonary arterial hypertension (PAH) with selexipag in a real-world, multi-center cohort, given that data supporting its use in pediatric PAH are sparse. Study designWe report a multi-center, retrospective, cohort study of children with PAH treated with selexipag. Demographic and clinical variables were extracted from the medical records. Clinical parameters were analyzed at 3 timepoints: pre-selexipag, 3-12 months post-selexipag, and >12 months follow-up. ResultsEighty-seven patients were included, 32 received selexipag as add-on to background therapy, and 55 transitioned from another prostanoid. Median starting and final doses were 4.7 and 28.5 μg/kg/dose BID, respectively. Add-on patients demonstrated improved indexed pulmonary to systemic vascular resistance ratio after selexipag initiation (PVRi/SVRi, 0.62v0.53, p=0.034) with a lower average mean pulmonary artery pressure (MPAP, 46v39 mmHg, p=NS), and oxygen consumption (VO2 max 27.8v30.9 mL/kg/min, p=NS). Transition patients demonstrated stable MPAP (47v45 mmHg, p=NS) and a lower mean PVRi (10.9v8.2 Wood units*m2, p=NS) but late functional worsening in some with VO2 max decreased at follow-up (26.0v19.5 ml/kg/min). Side effects were noted in 40% of the cohort but prompted discontinuation in only 2%. ConclusionsIn a large, multi-center cohort, the oral prostacyclin agonist selexipag demonstrates favorable tolerability and effectiveness. Add-on patients demonstrated early hemodynamic improvement. Transition patients demonstrated early stability with risk of late functional worsening, highlighting the importance of ongoing monitoring.

Effects of 9 Weeks of High- or Moderate-Intensity Training on Cardiorespiratory Fitness, Inhibitory Control, and Plasma Brain-Derived Neurotrophic Factor in Danish Adolescents-A Randomized Controlled Trial.

The primary aims of this study were to examine the effects of 9 weeks of aerobic training, comprising three 30-min sessions per week, on V̇O2max, inhibitory control, and plasma brain-derived neurotrophic factor (BDNF) levels among adolescents aged 16-19 years. One hundred twenty-one untrained or recreationally active adolescents from a Danish high school were enrolled in the study, with 58 females (17.8 ± 0.8 years) and 27 males (18.0 ± 0.9 years) completing it. Participants were randomly divided into three groups performing aerobic training at either moderate-intensity (MIT: 60%-70% heart rate reserve [HRR]) or high-intensity (HIT: 80%-100% HRR) or a passive control group (CON) continuing their habitual lifestyle. Both the training groups exercised for 3×30 min per week for 9 weeks using a combination of cycling and running. Before and after the intervention period maximal oxygen uptake (V̇O2max) and the primary outcomes (inhibitory control measured by a modified flanker task, and resting plasma levels of BDNF) were evaluated. After the intervention period, the HIT group demonstrated a larger increase in V̇O2max compared to both the CON and MIT groups, while no significant effects were observed on inhibitory control or plasma BDNF levels in any training group. However, compared to the CON group, the HIT group exhibited a tendency for greater improvement in the flanker interference score (accuracy), attributable to enhanced accuracy on the incongruent stimuli from pre to post. Aerobic training in adolescents increased cardiorespiratory fitness in an intensity-dependent manner, but no clear effects were observed on neither inhibitory control nor resting plasma BDNF levels. ClinicalTrials.gov: NCT02075944.

Total magnesium intake and risk of frailty in older women.

An adequate magnesium intake might lower the risk of frailty through its role in muscle function. We analysed data from 81524 women aged ≥60years participating in the Nurses' Health Study. Total magnesium intake was obtained from repeated food frequency questionnaires administered between 1984 and 2010 and self-reported information on supplementation. Frailty was defined as having at least three of the following five FRAIL scale criteria: fatigue, low strength, reduced aerobic capacity, having ≥5 chronic illnesses and weight loss≥5%. The occurrence of frailty was assessed every 4years from 1992 to 2018. Cox proportional hazards models adjusted for lifestyle factors, medication use and dietary factors were used to assess the association between magnesium intake and frailty. During a median follow-up of 16years, we identified 15477 incident cases of frailty. Women with a higher intake of total energy-adjusted magnesium had a decreased risk of frailty after adjustment for lifestyle factors, medication use and dietary factors. The relative risk (95% confidence interval) for Quintile 5 (Q5) versus Quintile 1 (Q1) was 0.88 (0.82, 0.94) (P-trend<0.001). When only energy-adjusted magnesium from the diet was considered, the inverse association was stronger (Q5 vs. Q1: 0.68 [0.56, 0.82]; P-trend<0.001). Those reaching the recommended daily allowance (RDA) of magnesium through diet had a 14% (9%, 19%) lower risk of frailty compared with those not meeting the RDA. Increased intake of foods rich in magnesium was associated with a decreased risk of frailty.

A Comparative Study of Body Composition and Aerobic Capacity between Water and Land Exercise Walking in Male College Students with Mild Obesity

This study explores the impact of water and land fitness walking on the body composition and aerobic capacity of mildly obese male college students. Employing a randomized controlled trial, 36 mildly obese male college students were divided into a water group, a land group, and a non-intervention control group. Following a 4-week exercise intervention, dual-energy X-ray absorptiometry and power bicycle tests assessed body composition and aerobic capacity. The results revealed that both the water and land groups significantly enhanced relative maximum oxygen uptake and lactate threshold, with the water group showing greater improvement. Additionally, water fitness walking significantly reduced body composition indicators including body weight, BMI, waist circumference, waist-to-hip ratio, and thigh circumference. However, there were no significant changes in height, chest circumference, muscle mass, and bone density. The research indicates that water fitness walking uniquely enhances aerobic exercise capacity and body composition, offering a scientific foundation for college students to select effective weight loss exercise methods.

Does Aerobic Capacity Change According to Position in Football Players?

Aerobic capacity plays an important role in football as it influences players' physical performance and long-lasting endurance levels. The aim of this study was to investigate the aerobic capacity levels of football players playing in different positions according to the positions they play. The study group consisted of 83 football players in super amateur league. Football players playing in 8 different positions voluntarily participated in the study (goalkeeper: n= 8, defender: n=13, left back: n=9, right back: n=7, midfield: n=24, left winger: n=7, right winger: n=7 striker: n=8). Yo-Yo Intermittent Recovery Test (YYIRT1) was applied to determine the aerobic endurance parameters of the players. One-way ANOVA analysis was used to compare the distance travelled, average speed (km/h) and maximum oxygen uptake (VO2max) values. It was determined that there was a significant difference between the test parameters of the players in different playing positions, and this difference was found to be between the left back players, goalkeepers, and stoppers (p&amp;lt;0.05). It was determined that goalkeepers had the lowest average aerobic capacity in the distances travelled by the players by position, while back players and wingers had high aerobic capacity averages. According to these results, we can say that the aerobic capacities of football players vary according to their positions, and the physiological demands of the position played by back players and wingers are effective in the distance travelled and the football players have different aerobic capacities.