Abstract The goal of this study is tracking of possible changes in the spectrum of the interstellar cloud seen along the sightline towards a runaway star AE Aur. The study considers variations in the radial velocities of the interstellar molecules and atoms, dwelling in the cloud, for the period ≈17 years. The most recent results of 6 year monitoring of equivalent widths variability for the CH and CH+ absorption lines are also presented. The study was done using the CH B-X(0,0) 3886 Å, A-X (0,0) 4300 Å and the CH+ A-X (1-0) 3958 Å, A-X (0,0) 4232 Å lines as well as the interstellar potassium K i 7699 Å line. Moreover a short discussion concerning the distance to the star is included. The present study is a continuation of our previous works and works of other researchers dedicated to the problem of small-scale structure in diffuse interstellar clouds. High resolution optical spectra from different spectrographs have been used in this work. The results of the study do not demonstrate significant changes in the radial velocities of the spectral features mentioned. The intensities of the CH and CH+ lines show slight tendency to vary at 1–3% level.