Adverse Socio-economic Consequences Research Articles

Association of Family Member Incarceration During Childhood and Smoking and Unhealthy Drinking Behaviors, Access to Care, and Functional Status Among Adults in the United States.

Incarceration can result in adverse socioeconomic and health consequences for individuals who have been incarcerated; these consequences extend to their children and may have impacts into later adulthood. To examine the association of family member incarceration (FMI) during childhood and smoking and unhealthy drinking behaviors, access to care, and functional status in later adulthood. Adults aged 18-64 and ≥ 65 with and without FMI during childhood from 42 states and Washington DC from the 2019-2022 Behavioral Risk Factor Surveillance System. Having FMI history was defined as "living with anyone during childhood who served time or was sentenced to serve time in a prison, jail, or other correctional facility." Study outcomes included 1) smoking and unhealthy drinking behaviors, 2) access to care (health insurance coverage, care affordability, having a usual source of care, and use of preventive services), and 3) functional status (e.g., having difficulty walking or climbing stairs). After adjusting for demographic characteristics and other adverse childhood experiences, compared to adults without FMI, adults aged 18-64 with FMI were more likely to report any history of smoking or unhealthy drinking (adjusted odds ratio (AOR): 1.19, 95% confidence interval (CI): 1.11-1.28), any access to care problems (AOR: 1.26, 95% CI: 1.12-1.42), and any functional limitations (AOR: 1.18, 95% CI: 1.10-1.28); adults aged ≥ 65 with FMI reported higher likelihood of reporting any smoking or unhealthy drinking behaviors (AOR: 1.23, 95% CI: 1.05-1.43) and impaired functional status (AOR: 1.30, 95% CI: 1.10-1.54). Associations were attenuated after additional adjustment for socioeconomic measures, especially educational attainment, but remained statically significant for multiple outcomes. FMI during childhood was associated with adverse health-related outcomes for adults of all ages. Developing programs to improve access to education and economic opportunities for adults with FMI may help mitigate the disparities.

Future Climate Change Shifts the Ranges of Major Encroaching Woody Plant Species in the Southern Great Plains, USA

AbstractWoody Plant Encroachment (WPE) is a key driver of grassland collapse in the Southern Great Plain (SGP), resulting in a series of adverse ecological and socioeconomic consequences. Climate change will interact with ongoing WPE as it will likely shift the potential ranges of WPE species. In this study, we employed an ensemble approach integrating results from multiple Species Distribution Models to project future distribution ranges of four major WPE species (Ashe juniper, honey mesquite, post oak, and eastern redcedar) in the SGP across the 21st century. The findings highlighted a noteworthy trend: under future climate conditions, the distribution ranges for these WPE species were projected to shift northward and eastward. Of particular concern is honey mesquite with significant expansion in distribution range, potentially covering up to two‐thirds of the SGP's non‐agricultural area by the end of the 21st century. Conversely, the other three WPE species were expected to experience a contraction in their distribution ranges. Ashe juniper may experience a decline in its current habitats in central Texas but gain new habitats in northern Texas, Oklahoma, and Kansas. The suitable ranges of post oak and eastern redcedar were projected to shrink eastward, primarily being restricted to eastern portions of Oklahoma and Texas under the RCP4.5 and a smaller area in eastern Oklahoma under the RCP8.5. The projected shift in WPE ranges provides a scientific basis for governments to optimize the allocation of management resources and implement timely practices to control the spread of woody plants during the early encroachment stage. Our study methodology is applicable to other regions and continents with WPE issues, including Africa, South America, and Australia.

Exploring the drivers of unmet need for contraception among adolescents and young women in Sierra Leone. a cross-sectional study

BackgroundSierra Leone grapples with a concerning reality: a high unmet need for contraception among adolescents and young women (AYW). This translates to a multitude of unintended pregnancies, jeopardising their health, education, and overall life trajectory. To effectively address this challenge, we aim to examine the factors associated with the unmet need for contraception among AYW in Sierra Leone.MethodsThe study analysed the 2019 Sierra Leone Demographic and Health Survey data. A total of 1,796 married and cohabiting AYW aged 15 to 24 years, representing the nationally representative sample, comprised the study. A multivariable binary regression analysis was used to explore the drivers of unmet needs for contraception. The regression results were presented using an adjusted odds ratio (AOR) with 95% confidence intervals (CI).ResultsThe study found that 29% of Sierra Leonean AYW had an unmet need for contraception. AYW with three or more births(AOR = 6.80, 95% CI = 3.97, 11.65), two births (AOR = 4.11, 95% CI = 2.50, 6.76), one birth (AOR = 4.40, 95% CI = 2.81, 6.88), heard family planning on TV last few months (AOR = 1.94, 95% CI = 0.98, 3.83), and are cohabiting (AOR = 1.88, 95% CI = 1.29, 2.75) had higher odds of unmet need for contraception. AYW who read the newspaper or magazine at least once a week (AOR = 0.11, 95% CI = 0.01, 1.10) had lower odds of unmet need for contraception.ConclusionsThe study found a high unmet need among AYW in Sierra Leone, which indicates a significant gap between desired and actual contraceptive use, leading to unintended pregnancies and potentially adverse health and socio-economic consequences. Parity, media exposure and cohabitation were associated with a higher unmet need for contraception and newspaper/magazine readership was associated with a lower unmet need for contraception. The study highlights the need to increase access to affordable and diverse contraceptive options, especially in rural areas. Expand educational campaigns beyond TV to include print media and community-based interventions. Provide AYWs with knowledge and authority to make well-informed decisions around their sexual and reproductive well-being.

Protocol of the study: Multilevel community-based mental health intervention to address structural inequities and adverse disparate consequences of COVID-19 pandemic on Latinx Immigrants and African refugees.

The NIMH-funded Multilevel Community-Based Mental Health Intervention to Address Structural Inequities and Adverse Disparate Consequences of COVID-19 Pandemic on Latinx Immigrants and African Refugees study aims to advance the science of multilevel interventions to reduce the disparate, adverse mental health, behavioral, and socioeconomic consequences of the COVID-19 pandemic that are a result of complex interactions between underlying structural inequities and barriers to health care. The study tests three nested levels of intervention: 1) an efficacious 4-month advocacy and mutual learning model (Refugee and Immigrant Well-being Project, RIWP); 2) engagement with community-based organizations (CBOs); and 3) structural policy changes enacted in response to the pandemic. This community-based participatory research (CBPR) study builds on long-standing collaboration with five CBOs. By including 240 Latinx immigrants and 60 African refugees recruited from CBO partners who are randomly assigned to treatment-as-usual CBO involvement or the RIWP intervention and a comparison group comprised of a random sample of 300 Latinx immigrants, this mixed methods longitudinal waitlist control group design study with seven time points over 36 months tests the effectiveness of the RIWP intervention and engagement with CBOs to reduce psychological distress, daily stressors, and economic precarity and increase protective factors (social support, access to resources, English proficiency, cultural connectedness). The study also tests the ability of the RIWP intervention and engagement with CBOs to increase access to the direct benefits of structural interventions. This paper reports on the theoretical basis, design, qualitative and quantitative analysis plan, and power for the study.

A typology of subseasonal rainfall evolution during the southern Niger monsoon.

Niger is highly vulnerable to rainfall variability, often with adverse socioeconomic consequences. This study examined observed subseasonal rainfall variability during Niger's monsoon season (May to September). Using k-means clustering of dekadal (ten-day) rainfall, a typology was developed for the annual evolution of the monsoon season. Year-to-year rainfall variability for each of the first few dekads of the season is modest, but the middle, or peak of the rainy season demonstrates large interannual variability. Clustering analysis of annual timeseries for each dekad of the season revealed two types of monsoon progression. The distinction between the two types is strongly dependent on differences during the latter half of the season. For the first and third ten-day periods in August, and the first ten days in September, the two groups of years are more distinct. These results imply that while reliable prediction of the timing of anomalous onsets will be challenging, due to the relatively narrow range of uncertainty historically, there are opportunities for further exploration of dynamic and or statistical predictors or precursors using this typology that could potentially provide better information for decision-makers, especially with respect to agriculture.

Body weight in childhood, adolescence, and young adulthood in relation to later risk of disabilities and early retirement among Danish female nurses.

Obesity is now the most common health problem in the younger population in Western societies and obesity rates are higher in lower socioeconomic status (SES) groups. We investigated whether overweight in childhood, independently of overweight in adulthood, influenced adult employment status and later risk of having disabilities. Using data from the Danish Female Nurse Cohort study, we examined associations between overweight in childhood/adolescence, and young adulthood and disabilities and early retirement in later adulthood (>44 years) and whether it was influenced by menopausal age (<or ≥52 years). We analysed data from 10,363 female nurses recruited in 1999, who reported whether they, as children, were larger or of similar weight size as their peers at any age below 13 years, between 13 and 19 years, their weights, and heights at 25 years, their current work situation and whether they had had disabilities for more than 6 months. Our results showed that overweight in childhood, adolescence and young adulthood was associated with an increased risk of disabilities and early retirement. Especially childhood overweight that did not persist into adulthood was associated with an increased risk of disabilities (OR = 1.82, 95% CI = 1.26-2.63) and early retirement (OR = 2.05, 95% CI = 1.38-3.03) in the postmenopausal group. A similar increased risk for disabilities (OR = 1.76, 95% CI = 1.26-2.47) was seen for adolescent overweight that did not persist into adulthood. The results show that in a well-educated population of women, overweight in childhood and/or adolescence had adverse socioeconomic consequences for later risk of disabilities and early retirement irrespective of weight status in adulthood.

Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults

Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture risk, particularly in older adults. Thus, new technologies are necessary to improve the accuracy of fracture risk estimation. In this observational study, we aimed to explore the association between serum cytokines and hip fracture status in older adults, and their associations with fracture risk using the FRAX reference tool. We investigated the use of a proximity extension assay (PEA) with Olink. We compared the characteristics of the population, functional status and detailed body composition (determined using densitometry) between groups. We enrolled 40 participants, including 20 with hip fracture and 20 without fracture, and studied 46 cytokines in their serum. After conducting a score plot and two unpaired t-tests using the Benjamini-Hochberg method, we found that Interleukin 6 (IL-6), Lymphotoxin-alpha (LT-α), Fms-related tyrosine kinase 3 ligand (FLT3LG), Colony stimulating factor 1 (CSF1), and Chemokine (C-C motif) ligand 7 (CCL7) were significantly different between fracture and non-fracture patients (p < 0.05). IL-6 had a moderate correlation with FRAX (R2 = 0.409, p < 0.001), while CSF1 and CCL7 had weak correlations with FRAX. LT-α and FLT3LG exhibited a negative correlation with the risk of fracture. Our results suggest that targeted proteomic tools have the capability to identify differentially regulated proteins and may serve as potential markers for estimating fracture risk. However, longitudinal studies will be necessary to validate these results and determine the temporal patterns of changes in cytokine profiles.

Rainfall extremes under future climate change with implications for urban flood risk in Kathmandu, Nepal

Increased rainfall extremes cause severe urban flooding in cities with adverse socio-economic consequences, and Kathmandu city is no exception. Rainfall events are projected to become more intense and frequent in a warm and wet future, and they pose a major challenge to the sustainable development of Kathmandu city. This paper analyses historical extreme rainfall patterns across the city and uses these as the basis for future projections in combination with a range of General Circulation Models. Future projections of extreme rainfall are then fed into the numerical flood model HAIL-CAESAR (Lisflood), using a high-resolution digital elevation model of Kathmandu. We show that rainfall intensity, such as the annual maximum 1-day rainfall (RX1day), is projected to increase by up to 72% in the future, and the historical 100-year return period rainfall will become a 20 or 25-year return period rainfall. The flood modelling results show that the future flood hazard (magnitude and extent) will increase. The historical 100-year return period flood discharge will correspond to a 25-year return period future flood. A 100-year period flood discharge is likely to increase up to 72% (37% median) in the future. Area of land inundated by more than 1 m in a 100-year return period flood event could increase from 11.7 km2 to 23 km2 in the future. Furthermore, the location and timing of rainfall maxima affect the peak, timing, and location of flood hazards. This analysis can serve as a scientific basis to assess future flood-induced risk in Kathmandu in response to climate change.

The effectiveness of immunomodulatory therapy with a synthetic analogue of the active center of the hormone thymus thymopoietin in the complex treatment of immunocompromised women with chronic infectious and inflammatory diseases of the pelvic organs

Chronic inflammatory diseases of the pelvic organs (pelvic inflammatory disease, PID) in women is among the main understudied problems in gynecology worldwide with adverse medical and socio-economic consequences, thus justifying the need for further study of immunopathogenesis and development of new approaches to treatment. Our objective was to develop new immunotherapeutic approaches to correction of combined disorders of the immune system functioning in immunocompromised women with PID and to evaluate their clinical and immunological efficacy.&#x0D; 55 women aged 20-40 years were examined, i.e., 35 patients with exacerbation of sluggish or recurrent PID, resistant to conventional therapy. Testiung was performed before complex treatment (study group 1 GI- 1) and after the course (study group 2 GI-2). Contents of T and B lymphocytes, natural killer cells (NK) (CYTOMICS FC500, USA), phagocytic and microbicidal functions of neutrophilic granulocytes (NG) were assessed in SG-1 and SG-2 before and 2-3 days after complex treatment with addition of an immunotherapeutic drug based on hexapeptide (HP) at a daily dose of 45 mg/ml intramuscularly for 10 days.&#x0D; In patients from SG-1, a decrease in T cells (CD3+CD19- ) and B cells (CD3-CD19+), a 2-fold increase in the content of NK CD3-CD16+CD56+ was found, along with altered functioning of NG (deficiency of actively phagocytizing NG, a decrease in their digestive function and NADPH-oxidase activity). In SG-2 patients, the treatment was followed by restoration of the T (CD3+CD19-) and B cells (CD3-CD19+), NK cells (CD3-CD16+CD56+), like as an increase in effector functions, i.e., microbial capture by NG and their killing ability due to activation of NADPH oxidases and normalization of microbicidal reserve capacity in the NG cell population. Positive clinical effect included reduction of clinical symptoms in acute period, absence of PID exacerbations over follow-up for 6 months (85.6% of cases). Occasional exacerbations of PID were associated with medical manipulations (5.7%) and unprotected sexual contacts (5.7%).&#x0D; The immunopathogenetically proven approach to correction of combined functional impairment of immune system in the women with PID shows a positive clinical and immunological effect.

A STUDY TO ASSESS THE IMPACT OF COVID19 ON MATERNITY CARE PRACTICES AND CHILD BEARING EXPERIENCES AMONG ANTENATAL MOTHER AT SELECTED COMMUNITY AREA, PUDUCHERRY

Childbearing women and newborn infants continue to require safe family centered care during COVID19 pandemic and they represent a vulnerable population. The Covid-19 pandemic affects maternal health both directly and indirectly are intertwined. Pregnant women and mothers were not found to be at higher risk for COVID-19 infection than people who are not pregnant, however pregnant people with symptomatic COVID-19 may experience more adverse outcomes compared to non-pregnant people and seem to face disproportionate adverse socio-economic consequences. The study was conducted at selected community areathirubuvanai,Puducherry. The period of data collection was 1week and the data were collected from 50 antenatal mother by using structured questionnaires. Majority of high level of impact were 41(82%) and low level of impact were 9 (18%), the mean were 14.98 and standard deviation were 4.50.The result shows that antenatal mothers having high level of impact on covid-19 during child bearing practice.

Application of triple bottom line concept to artisanal and small-scale mining activities in Wa East District, Ghana

&lt;p align="justify"&gt;The artisanal and small-scale mining (ASM) sector offers a supplementary livelihood strategy to agriculture in northern Ghana, acting as a source of capital to support agriculture. However, the sector has been associated with several adverse environmental and socio-economic consequences, making its sustainability dimensions extremely complex and inconclusive across the literature. This study sought to investigate the dynamics of ASM operations in line with the Triple Bottom Line concept. Specifically, the paper explored the influence of the small-scale mining law and institutional framework on ASM operations, examined the relationship between the economic benefits of ASM and other livelihood activities, and assessed the adverse environmental effects of ASM in the host communities. The research design was a mixed method and cross-sectional survey. Household questionnaires, semi-structured interviews and non-participant observation were the main primary data collection techniques. Secondary data were provided by satellite images sourced from USGS Earth Explorer. They were analysed to determine the land cover types. The results indicate that the relevant regulatory state institutions lag behind their law enforcement duty. The ASM is a lucrative job that provides quick income to the youth. However, ASM activities affect food crop farming and decrease the quantity and quality of vegetation causing variations in land cover. Consequently, the host communities and ASM cooperatives have employed some land reclamation strategies. The study recommends increased government support to the relevant regulatory state institutions to constantly monitor and sanitize the ASM sector. To eradicate illegal mining, the study advocates for multi-stakeholder consultation and action.&lt;/p&gt;

Socio-economic Implications of IPOB’s sit-at-home Order in South-East, Nigeria: A Preliminary Qualitative Investigation

The Indigenous People of Biafra (IPOB) have been agitating for their self determination since 2012. And the arrest and extradition of their supreme leader, Mazi Nnamdi Kanu from Kenya heightened insecurity in South-East. IPOB initiated sit-at home order in South-East to create awareness locally and internationally in their bid to securing the release of their leader. The sit-at-home order has adverse socioeconomic consequences as it was later hijacked by hoodlums who committed havoc in the region. This study examined the socio-economic implications of IPOB’s sit-at-home order in South-East, Nigeria. The study adopted social contract theory as framework, whereas descriptive design was employed. Purposive sampling technique was utilized with a sample of thirty-six interviewees, thirty In-depth interviews and six Key informants selected from market leaders, religious leaders and school principals. Qualitative data were content analyzed with the aid of Nvivo software. IPOB’s sit-athome order in South-East Nigeria has great negative socio-economic implications on the people of the area. South-East economy was highly devastated. Foreign investments were eluded, insecurity, unemployment and underdevelopment became the order of the day as hoodlums hijacked the protest and committed series of atrocities in the region, hence the decline in economic activities, standard of education and high mortality rate. There is great need for dialogue geared towards securing the release of IPOB leader from detention so as to halt further devastating socio-economic effects of the sit-at-home order in South-East region.

Çocukluk Çağı Kanseri

Kanser fizyolojik bir bozukluk olan tümör oluşumuyla kendini gösteren kontrolsüz hücre çoğalması ile karakterize olan bir hastalıktır. Çocukluk çağı kanseri çocuklarda önde gelen ölüm nedenidir. Dünya Sağlık Örgütünün çocuk sağlığına yaptığı vurgunun ardından, dünya çapındaki çoğu hükümet çocukluk çağı kanser araştırmalarını kolaylaştırmak için önlemler almıştır. Multimodalite terapisinin ortaya çıkmasıyla birlikte son beş yılda kanserden ölüm oranının azaldığını ve bugün çoğu Avrupa ve Kuzey Amerika ülkesinde kanserde sağ kalımın %80’i aştığı görülmektedir. Hayatta kalmadaki önemli gelişmeler, çocukluk çağı kanserden kurtulanların sürekli artan bir popülasyonuna yol açmıştır. Çocukluk çağı kanserinden kurtulanlar, kanser ve tedavisinde atfedilebilecek çeşitli ağır bedensel, zihinsel sağlık durumlarının yanı sıra olumsuz sosyal, sosyoekonomik sonuçlara ve azalmış psikolojik refah ile yaşam kalitesi de risk altındadır. Çocuklarda erken tanı önemlidir çünkü yetişkinlerdeki gibi tarama testleri yoktur burada görev çocuğun takibini yapan hekimlere düşmektedir. Çalışmalar, günlük fiziksel aktivitedeki azalmanın kronik hastalıkların/durumların birincil nedeni olduğu ve fiziksel aktivitenin/egzersizin hareketsizliğin neden olduğu işlev bozukluklarının rehabilitasyon tedavisi (terapi) olduğu fikrini kanıtlıyor. Bu derlemenin amacı çocukluk çağı kanseri hakkında genel bilgileri ve fiziksel aktivitenin etkilerinin incelenmesidir.

Role of the ghrelin system in alcohol use disorder and alcohol-associated liver disease: A narrative review.

Unhealthy alcohol consumption is a global health problem. Adverse individual, public health, and socioeconomic consequences are attributable to harmful alcohol use. Epidemiological studies have shown that alcohol use disorder (AUD) and alcohol-associated liver disease (ALD) are the top two pathologies among alcohol-related diseases. Consistent with the major role that the liver plays in alcohol metabolism, uncontrolled drinking may cause significant damage to the liver. This damage is initiated by excessive fat accumulation in the liver, which can further progress to advanced liver disease. The only effective therapeutic strategies currently available for ALD are alcohol abstinence or liver transplantation. Any molecule with dual-pronged effects at the central and peripheral organs controlling addictive behaviors and associated metabolic pathways are a potentially important therapeutic target for treating AUD and ALD. Ghrelin, a hormone primarily derived from the stomach, has such properties, and regulates both behavioral and metabolic functions. In this review, we highlight recent advances in understanding the peripheral and central functions of the ghrelin system and its role in AUD and ALD pathogenesis. We first discuss the correlation between blood ghrelin concentrations and alcohol use or abstinence. Next, we discuss the role of ghrelin in alcohol-seeking behaviors and finally its role in the development of fatty liver by metabolic regulations and organ crosstalk. We propose that a better understanding of the ghrelin system could open an innovative avenue for improved treatments for AUD and associated medical consequences, including ALD.

The Trade-Off between Airborne Pandemic Control and Energy Consumption Using Air Ventilation Solutions.

Airborne diseases cause high mortality and adverse socioeconomic consequences. Due to urbanization, more people spend more time indoors. According to recent research, air ventilation reduces long-range airborne transmission in indoor settings. However, air ventilation solutions often incur significant energy costs and ecological footprints. The trade-offs between energy consumption and pandemic control indoors have not yet been thoroughly analyzed. In this work, we use advanced sensors to monitor the energy consumption and pandemic control capabilities of an air-conditioning system, a pedestal fan, and an open window in hospital rooms, classrooms, and conference rooms. A simulation of an indoor airborne pandemic spread of Coronavirus (COVID-19) is used to analyze the Pareto front. For the three examined room types, the Pareto front consists of all three air ventilation solutions, with some ventilation configurations demonstrating significant inefficiencies. Specifically, air-conditioning is found to be efficient only at a very high energy cost and fans seem to pose a reasonable alternative. To conclude, a more informed ventilation policy can bring about a more desirable compromise between energy consumption and pandemic spread control.

Experimental in vitro reprogramming of transformed phenotype of neutrophil granulocyte subpopulations in women with chronic recurrent infectious and inflammatory conditions of genital tract

Chronic inflammatory diseases of the pelvic organs (CIDPO) in women represent one of the urgent and insufficiently studied problems in gynecology across the world. These disorders are followed by adverse medical and socio-economic consequences, i.e., chronic local inflammatory process, chronic pelvic pain syndrome, ectopic pregnancy, infertility. Due to increasing chronicity and recurrence rates of genital infections and inflammatory diseases, there is a need for further studying the effector and regulatory mechanisms of immune system. Of special relevance are the studies of the receptor transformation in neutrophilic granulocytes (NG), the basic population of antimicrobial defense, with further substantiation of targeted immunomodulatory therapy. Purpose of the present study was to assess transformation of neutrophilic granulocytes from CD11b+CD64-CD32+CD16+ to that CD11b+CD64+CD32+CD16+ phenotype in immunocompromised women with CIDPO exacerbation, as well as to evaluate the possibility of in vitro reprogramming the neutrophile phenotype under the action of recombinant interferon (recIFN2b). Peripheral blood neutrophils were tested in the comparison group of 10 conditionally healthy women 20 to 40 years old, and in 17 women (20-40 years old) with the CIDPO exacerbation (group 1). The in vitro effect of recIFNa2b on the blood neutrophils was evaluated for 17 women with CIDPO (group 2). Flow cytometric technique (FCT, CYTOMICS FC500, Beckman Coulter, USA) was used to determine the number of NGs and cell receptor expression levels of neutrophilic CD11b+CD64-CD32+CD16+NG and CD11b+CD64+CD32+CD16+ subpopulations. In peripheral blood of women with CIDPO exacerbation, an increased expression density of surface membrane molecules was revealed by means of FCT: in the subpopulation CD11b+CD64-CD32+CD16+NG, CD16 proved to be 91.7% higher; in CD11b+CD64+CD32+CD16+NG subpopulation, CD16 was increased by 116%, and CD32 being higher by 81% against the comparison group. In the in vitro system, during the incubation of PB with recIFN2b (group 2), we have revealed an increased number of CD11b+CD64-CD32+CD16+ subpopulation relative to the comparison group and group 1, and significantly increased expression density of CD16 (by 212%); CD11b (by 56%), and CD32 (by 83%) than in comparison group, as well as higher density of CD16 expression by 163%; CD11b (by 223%) compared to group 1. The changes in expression density of membrane molecules was also detected by FCT for the activated subpopulation CD11b+CD64+CD32+CD16+NG, i.e., an increase in CD16 by 232% against control group, and decreased expression density of CD64 by 150% against the background, along with increased density of CD16 expression (by 54%), and CD11b (by 103%), relative to group 1, thus suggesting a reprogramming of negatively transformed NC phenotype. These findings may be considered a positive immunomodulatory effect providing a basis for further research in order to develop new integrated approaches to treatment of CIDPO of various etiologies.

Determinants of COVID-19 Infections on Sea-Going Ships and Their Socio-Economic Consequences for Seafarers and Shipowners in Terms of Modeling Ship Emergency Procedures

The COVID-19 pandemic has caused many negative socio-economic consequences for seafarers and shipowners of such importance that, on the one hand, it inspired and, on the other hand, it became an impulse to undertake research in this direction. It seems that avoiding at least some consequences would be possible if both shipowners and ship masters operated based on safety management procedures strictly adapted to the pandemic situation. Of course, many crisis management procedures have been developed in maritime practice so far. Still, they mainly relate to such events as maritime incidents, maritime accidents, maritime disasters, oil spills, terrorist attacks, or sea piracy. However, they do not consider the specificity of a crisis situation created for the safety of the ship’s crew by the global pandemic. Its appearance made all maritime transport entities, especially shipowners, aware of the lack of preparation for such an eventuality. Based on the general recommendations of international organizations, such as the WHO (World Health Organization) or the IMO (International Maritime Organization), they began developing and implementing urgent procedures for handling ships under COVID-19 conditions. Since the recommendations were formulated generally and the pandemic spread very quickly, the prevention and response procedures for a ship found to be affected by COVID-19 were developed ad hoc and, therefore, were often flawed. Consequently, it was concluded that it is worth creating a universal model of the procedure for dealing with a sea-going ship in pandemic conditions and reducing the adverse socio-economic consequences for shipowners and seafarers. This became the primary goal of the research undertaken in this direction, and this goal was closely related to the adopted central research hypothesis. The substance of the matter comes down to the fact that knowledge of the factors causing coronavirus infections will allow the development and implementation of effective procedures for handling ships in pandemic conditions. It will also reduce the risk and consequences of coronavirus infections. COVID-19 infections can be caused by many factors that are beyond the control of the shipowner and the ship’s captain. Still, there are also those factors that they can control and thus eliminate or at least reduce the risk of contracting the coronavirus by the crew. Thus, their correct identification, ranking their importance in terms of the risk of infection, and then focusing on the elimination of the most important of them is the basis for building a universal model, in the sense of the possibility of applying to any sea-going ship in pandemic conditions. The work includes RCA (Root Cause Analysis), stratification analysis, weighted Ishikawa diagram, and Lorenz-Pareto chart. The primary sources of information used in the research came from the literature review, the analysis of normative acts, the analysis of documentation and procedures on board ships in pandemic conditions, questionnaire research, direct and focus interviews, and participant observation.

The role of physico-chemical interactions in the seasonality of toxic dinoflagellate cyst assemblages: The case of the NW Patagonian fjords system

Harmful algal blooms (HABs) are recurrent in the NW Patagonia fjords system and their frequency has increased over the last few decades. Outbreaks of HAB species such as Alexandrium catenella, a causal agent of paralytic shellfish poisoning, and Protoceratium reticulatum, a yessotoxins producer, have raised considerable concern due to their adverse socioeconomic consequences. Monitoring programs have mainly focused on their planktonic stages, but since these species produce benthic resting cysts, the factors influencing cyst distributions are increasingly gaining recognition as potentially important to HAB recurrence in some regions. Still, a holistic understanding of the physico-chemical conditions influencing cyst distribution in this region is lacking, especially as it relates to seasonal changes in drivers of cyst distributions, as the characteristics that favor cyst preservation in the sediment may change through the seasons. In this study, we analyzed the physico–chemical properties of the sediment (temperature, pH, redox potential) and measured the bottom dissolved oxygen levels in a “hotspot” area of southern Chile, sampling during the spring and summer as well as the fall and winter, to determine the role these factors may play as modulators of dinoflagellate cyst distribution, and specifically for the cysts of A. catenella and P. reticulatum. A permutational analysis of variance (PERMANOVA) showed the significant effect of sediment redox conditions in explaining the differences in the cyst assemblages between spring-summer and fall-winter periods (seasonality). In a generalized linear model (GLM), sediment redox potential and pH were associated with the highest abundances of A. catenella resting cysts in the spring-summer, however it was sediment temperature that most explained the distribution of A. catenella in the fall-winter. For P. reticulatum, only spring-summer sediment redox potential and temperature explained the variation in cyst abundances. The implications of environmental (physico-chemical) seasonality for the resting cysts dynamics of both species are discussed.

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection.

The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples. In the present article, we review the state-of-the-art use of SERS for chemical analysis of illicit drugs in aqueous and complex biological samples, including saliva, urine, and blood. We also include a review of the types of SERS substrates used for this purpose, pointing out recent advancements in substrate fabrication towards quantitative and qualitative detection of illicit drugs. Finally, we conclude by providing our perspective on the field of SERS-based drug detection, including presently faced challenges. Overall, our review provides evidence of the strong potential of SERS to establish itself as both a laboratory and in situ analytical method for fast and sensitive drug detection and identification.

Abstract TP86: Depression And Anxiety After Stroke In A Young Adult Population

Background and Objectives: We aimed to determine the prevalence of poststroke depression (PSD) and anxiety as well as to identify their predictors in a population of young Filipino adults. Methods: We performed a cross-sectional epidemiologic study in the largest tertiary hospital in the Philippines. The study involved the administration of a structured survey tool and review of medical records. The Hospital Anxiety and Depression Score was used to screen for anxiety and depression. Chi-square tests and Fisher’s exact tests were used to compare between groups with anxiety or depression and those without. Multivariable logistic regression analysis was performed to determine significant socio-economic and clinical risk factors of PSD and anxiety. Results: In our study population of 114 young adult stroke patients, the prevalence of depression was 20.2% while the prevalence of anxiety was 34.2%. Significant predictors of PSD were the presence of anxiety (OR 1.84; CI 1.05-3.22), lower mRS scores (mRS 3-5 OR 5.52; 95% CI 1.09-8.03) and diabetes (OR 2.09; 95% CI 1.67-6.26). Meanwhile, significant predictors of poststroke anxiety included depression (OR 7.5; 95% CI 5.02-21.94) and dependence (Barthel Index scores 95-100; OR 0.32; 95% CI 0.14-0.71). Relationship status, educational attainment, stroke subtype and stroke location were not found to be significant predictors of PSD and anxiety. Conclusion: Our study showed that young adult patients who suffer from stroke are at risk for adverse socio-economic and psychiatric consequences. A significant proportion of the population had depression and anxiety after stroke. Clinicians should be aware of these conditions that influence the outcomes of young adult stroke patients.