Drought and climate change are one of the most important environmental health challenges of the current century. It has been predicted that the occurrence of drought, its intensity, and its adverse effects on the environment, human health, societies, and economy will increase in the coming decades. This qualitative content analysis study aimed to explore the impact of drought on the lives of people living in the south of Iran. Data were collected through in-depth semi-structured interviews with farmers, urban and rural officials, and physicians. A total of 25 interviews were conducted. All interviews were recorded and then transcribed. Data were analyzed using MAXQDA version 18. The concepts raised by interviewees regarding the consequences of drought were categorized into four themes, including economic consequences, environmental hazards, health consequences, and adaptation options; and most of these consequences were inter-related. Participants believed that drought has affected the soil, environment, ecosystem, and the quality and quantity of water, and this can lead to extensive effects on humans’ physical, mental, and community wellbeing. Drought can also cause adverse economic effects, which can further intensify its adverse effects. It seems like the adverse effects of drought in Iran are severe and destructive, and this is due to the mismanagement of water and environmental resources and other socio-economic problems. Fundamental changes in the management of water and environmental resources are necessary.