Interhemispheric signal transmission in the Atlantic Ocean connects the deep water production regions of both hemispheres. The nature of these interactions and large‐scale responses to perturbations on timescales of years to millennia have been investigated using a global three‐dimensional ocean general circulation model coupled to a dynamic‐thermodynamic sea ice model. The coupled model reproduces many aspects of today's oceanic circulation. A set of experiments shows the sensitivity to changes in different surface boundary conditions. Buoyancy changes in the Weddell and Labrador Seas exert a direct effect on the overturning cells of the respective hemisphere. They influence the density structure of the deep ocean and thereby lead to alterations in the strength of the ACC. Changing the wind stress south of 30°S influences the magnitude of the deep water production of both hemispheres. The interhemispheric effect in these experiments cannot be explained solely by advective mechanisms. Switching off the wind stress over the latitude band of the Drake Passage leads to a slow gradual decrease of the water mass transport in the ACC, resulting in an almost complete cessation. The model results prove the necessity to continue integrations over thousands of years until new equilibria are established.