Advances In Synthetic Applications Research Articles

Diarylation of N- and O-nucleophiles through a metal-free cascade reaction

Diarylation of N- and O-nucleophiles through a metal-free cascade reaction

Electro-/photocatalytic alkene-derived radical cation chemistry: recent advances in synthetic applications.

Alkene-derived radical cations are versatile reactive intermediates and have been widely applied in the construction of complex functionalized molecules and cyclic systems for chemical synthesis. Therefore, the synthetic application of these alkene-derived radical cations represents a powerful and green tool that can be used to achieve the functionalization of alkenes partially because the necessity of stoichiometric external chemical oxidants and/or hazardous reaction conditions is eliminated. This review summarizes the recent advances in the synthetic applications of the electro-/photochemical alkene-derived radical cations, emphasizing the key single-electron oxidation steps of the alkenes, the scope and limitations of the substrates, and the related reaction mechanisms. Using electrocatalysis and/or photocatalysis, single electron transfer (SET) oxidation of the CC bonds in the alkenes occurs, generating the alkene-derived radical cations, which sequentially enables the functionalization of translocated radical cations to occur in two ways: the first involves direct reaction with a nucleophile/radical or two molecules of nucleophiles to realize hydrofunctionalization, difunctionalization and cyclization; and the second involves the transformation of the alkene-derived radical cations into carbon-centered radicals using a base followed by radical coupling or oxidative nucleophilic coupling.

Recent Advances in Ruthenium-Catalyzed Carbene/Alkyne Metathesis (CAM) Transformations

Carbene intermediates have shown versatile applications in modern synthetic chemistry. Catalytic ruthenium carbene/alkyne metathesis (CAM) with readily available substrates renders an efficient procedure for the in situ generation of ruthenium vinyl carbene intermediates. Here, recent advances in synthetic applications of ruthenium-catalyzed carbene/alkyne metathesis (CAM) are highlighted.1 Introduction2 Ruthenium Vinyl Carbenes through Carbene/Alkyne Metathesis (CAM)3 Nonpolar Transformations of Ruthenium Vinyl Carbenes4 Polar Transformations of Ruthenium Vinyl Carbenes4.1 Intramolecular Ruthenium-Catalyzed [1,5]- and [1,6]-Hydride Transfer/Cyclization4.2 Heterocyclizations of Alkynals and Alkynones4.3 Heterocyclizations of ortho-(Alkynyloxy)benzylamines5 DFT Studies on the Stereoselectivity of the CAM Reaction6 Conclusions

Recent Advances in Synthetic Applications of Polyvinylpyrrolidone Supported Reagents and Catalysts

Academic Journal of Polymer science (AJOP) is a Journal which publishes state-of-the-art overview articles by internationally recognized authorities in polymer science and engineering. It covers all the areas of particular interest are biomedical applications,

Recent Advances in ω-Transaminase-Mediated Biocatalysis for the Enantioselective Synthesis of Chiral Amines

Chiral amines are important components of 40–45% of small molecule pharmaceuticals and many other industrially important fine chemicals and agrochemicals. Recent advances in synthetic applications of ω-transaminases for the production of chiral amines are reviewed herein. Although a new pool of potential ω-transaminases is being continuously screened and characterized from various microbial strains, their industrial application is limited by factors such as disfavored reaction equilibrium, poor substrate scope, and product inhibition. We present a closer look at recent developments in overcoming these challenges by various reaction engineering approaches. Furthermore, protein engineering techniques, which play a crucial role in improving the substrate scope of these biocatalysts and their operational stability, are also presented. Last, the incorporation of ω-transaminases in multi-enzymatic cascades, which significantly improves their synthetic applicability in the synthesis of complex chemical compounds, is detailed. This analysis of recent advances shows that ω-transaminases will continue to provide an efficient alternative to conventional catalysis for the synthesis of enantiomerically pure amines.

ChemInform Abstract: Advances in Synthetic Applications of Hypervalent Iodine Compounds

AbstractReview: 1601 refs.

Advances in Synthetic Applications of Hypervalent Iodine Compounds.

The preparation, structure, and chemistry of hypervalent iodine compounds are reviewed with emphasis on their synthetic application. Compounds of iodine possess reactivity similar to that of transition metals, but have the advantage of environmental sustainability and efficient utilization of natural resources. These compounds are widely used in organic synthesis as selective oxidants and environmentally friendly reagents. Synthetic uses of hypervalent iodine reagents in halogenation reactions, various oxidations, rearrangements, aminations, C-C bond-forming reactions, and transition metal-catalyzed reactions are summarized and discussed. Recent discovery of hypervalent catalytic systems and recyclable reagents, and the development of new enantioselective reactions using chiral hypervalent iodine compounds represent a particularly important achievement in the field of hypervalent iodine chemistry. One of the goals of this Review is to attract the attention of the scientific community as to the benefits of using hypervalent iodine compounds as an environmentally sustainable alternative to heavy metals.

ChemInform Abstract: Polymer-Supported Reagents and Catalysts: Recent Advances in Synthetic Applications

The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.

Polymer-supported reagents and catalysts: recent advances in synthetic applications.

The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.

Hypervalent Iodine Compounds: Recent Advances in Synthetic Applications

Hypervalent Iodine Compounds: Recent Advances in Synthetic Applications

ChemInform Abstract: Recent Advances in Synthetic Applications of Nitrile Oxide Cycloaddition (1981 ‐ 1989)

ChemInformVolume 21, Issue 35 Reviews ChemInform Abstract: Recent Advances in Synthetic Applications of Nitrile Oxide Cycloaddition (1981 - 1989) S. KANEMASA, S. KANEMASA Inst. Adv. Mat. Stud., Kyushu Univ., Kasuga 816, JapanSearch for more papers by this authorO. TSUGE, O. TSUGE Inst. Adv. Mat. Stud., Kyushu Univ., Kasuga 816, JapanSearch for more papers by this author S. KANEMASA, S. KANEMASA Inst. Adv. Mat. Stud., Kyushu Univ., Kasuga 816, JapanSearch for more papers by this authorO. TSUGE, O. TSUGE Inst. Adv. Mat. Stud., Kyushu Univ., Kasuga 816, JapanSearch for more papers by this author First published: August 28, 1990 https://doi.org/10.1002/chin.199035338Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue35August 28, 1990 RelatedInformation

Recent Advances in Synthetic Applications of Nitrile Oxide Cycliaddition (1981-1989)

The synthetic applications of nitrile oxide cycloadditions, developed in the 1980s, are briefly reviewed. Topics discussed in the present review are the modern developments on the generation methods of nitrile oxides, on the cycloadditions with multiple bonds other than carbon-carbon double and triple bonds, on reductive cleavage of the nitrogen-oxygen bonds of 2-isoxazolines, on the unmasking of functionalities, and on the asymmetric cycloadditions of nitrile oxides