Advances In Inorganic Chemistry Research Articles

Metal Complexes in Biology and Medicine: The System Cadmium ((II))/ Iron ((II))/ Zinc ((II)) - α - Aminobutenoic Acid

Metal ions play an important role in biological system. The importance of metal ions to essential functions of living systems and for wellbeing of living organisms is well known. Metal ions are fundamental elements for the maintenance of life spans of the human, animals, and plants. Recent advances in inorganic chemistry have made possible formation of number of transition metal complexes with organic ligand of interest, which can be used as therapeutic agent. In coordination compounds studies, knowledge of the stability constants of complexes is necessary for preliminary quantitative treatment. The present technique involving the use of paper electrophoresis is described for the study of equilibria in binary complex systems in solution. The method is based on the movement of a spot of a metal ion in an electric field at various pH’s of background electrolyte. A graph of pH versus mobility was used to obtained information in the binary complexes and to calculate its stability constants. Using this method , the stability constants of binary complexes metal (II) – α – aminobutenoic acid have been determined to be ( 3.78 ± 0.01, 2.48 ± 0.03 ); ( 3.27 ± 0.04, 2.33 ± 0.07 ); and (4.45 ± 0.02, 2.66 ± 0.05); (logarithm stability constant values) for cadmium (II), iron (II) and zinc (II) complexes, respectively, at ionic strength 0.01 Mol / L and a temperature of 35º C.

Implicatons of Metal Complexes in Biology and Medicine the System Cadmium (II)/ Iron (II)/ Zinc (II)-Hydroxyproline

The importance of metal ions to essential functions of living systems and for the well being of living organisms is known. Metal ions are fundamental elements for the maintenance of the life spans of the human, animals and plants. The stability constants of Cd2+, Fe2+ and Zn2+ complexes with hydroxyproline were determined by Paper Electrophoretic Technique (PET). This method is based on the movement of a spot of metal ion in an electric field at various pH of background electrolyte. A graph of pH against mobility gives information about the formation of binary complexes and permit to calculate their stability constants. The stability constant of the ML and ML2 complexes of Cd (II) – hydroxyproline, Fe (II) – hydroxyproline and Zn (II) – hydroxyproline, have been found to be (4.41 ± 0.01; 2.95 ± 0.06) (4.11 ± 0.01; 2.81 ± 0.11 and (4.83 ± 0.02; 3.28 ± 0.07) ( logarithm stability constant values), respectively at ionic strength 0.1 mole L-1 (per chloric acid as background electrolyte) and a temperature of 35 0C, The first and second stability constants of metal complexes follow the order Zn (II) > Cd (II) > Fe (II). Metal complexes can offer their action such as anti-inflammatory, antibiotic, anti-thyroid and anticancer compounds. Metal based drugs bioactivity can be increased by metal chelation, which in turn increase their absorbance and stability. Recent advances in inorganic chemistry have made possible formation of a number of metal complexes with organic ligands of interest which can be use as therapeutic agents.

Metal Complexes in Medicine: An Overview and Update from Drug Design Perspective

Metals are essential cellular components selected by nature to function in several indispensable biochemical processes for living organisms. Transition metal complexes are important in catalysis, materials synthesis, photochemistry, and biological systems. Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. The use of metals and their salts for medicinal purposes has been present throughout history. With the advancement in the field of inorganic chemistry the role of transition metal complexes as therapeutic compounds is becoming increasingly important. Recent advances in inorganic chemistry have made possible formation of number of transition metal complexes with organic ligand of interest, which can be used as therapeutic agent. This review illustrates the role of metals and the recent progress in the field of medicinal bioinorganic chemistry with new approaches to the design of innovative metal-based drugs and their application.

2019 Great Lakes Regional Meeting

The American Chemical Society Joliet and Chicago Local Sections will host the 2019 Great Lakes Regional Meeting at the Sheraton Lisle Naperville Hotel in Lisle, Illinois, May 1–4. Technical program. The meeting theme is “Chemistry Connections: Careers, Education, and Sustainability.” Symposia sessions will highlight advances in inorganic chemistry, electrochemistry, physical chemistry and spectroscopy, chemical education, materials chemistry, organic chemistry, medicinal chemistry, consumer chemistry, analytical chemistry, and biorelated chemistries. There will also be a general poster session and technical workshops. On Wednesday evening, 2016 Nobel laureate Sir Fraser Stoddart will deliver the keynote lecture. In addition, a symposium on photochemistry will honor Frederick D. Lewis, a professor emeritus at Northwestern University. The ACS Joliet Section will sponsor a symposium in honor of Marcetta Darensbourg, a chemistry professor at Texas A&M University, and the ACS Chicago Section will present he...

ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry: Thomas B. Rauchfuss

ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry: Thomas B. Rauchfuss

ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry: William B. Tolman

NATIONAL AWARDS ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry: William B. Tolman ShareShare onFacebookTwitterWechatLinked InRedditEmail C&EN, 2017, 95 (1), pp 48–50January 2, 2017Cite this:C&EN 95, 1, 48-50William B. Tolman (Credit: Eileen Harvala )Figure1of1Sponsor: Strem Chemicals Citation: For impactful contributions to our understanding of copper centers in biology and catalysis and outstanding leadership in service to the inorganic chemistry and larger community. Current position: Distinguished McKnight University Professor and chair of the department of chemistry, University of Minnesota Education: B.A., chemistry, Wesleyan University; Ph.D., chemistry, University of California, Berkeley Tolman on what gets his creative juices flowing: “Talking to students about their science and seeing new and unexpected data! In the next decade, I hope to continue to do good science, educate and motivate students, and play a key role in driving positive change in our profession and in the institutions with which I am affiliated, all for the greater good of society.” What his colleagues say: “Bill’s work on the synthesis, characterization, and reactivity of novel copper complexes relevant to copper-containing metalloenzyme active sites has been particularly impactful. He is deeply committed to the broader inorganic chemistry community and has shown this commitment through myriad activities that go well beyond the norm.”—Lawrence Que, University of Minnesota

John D. Corbett (1926-2013)

John D. Corbett (1926-2013)

ADVENTURES OF QUANTUM CHEMISTRY IN THE REALM OF INORGANIC CHEMISTRY

Recent improvements in the design of faster and more efficient algorithms have placed powerful computational quantum chemistry tools in the hands of all chemists. ab initio and density functional calculations are routinely performed by non-specialists in the field. These computational tools have nowadays become as useful to the bench chemist as spectrometers and vacuum lines. The impact of modern computational technology in the advancement of inorganic chemistry is outlined herein. Attempts have been made to present only the background information required to appreciate the general features of the computational quantum chemical techniques available and the types of chemical problems that can be reasonably solved in the growing field of quantum inorganic chemistry. It should be stressed that quantum chemical calculations assist experimental studies by accurately predicting chemical behavior. This is why a blend of theory and experiment must be effectively employed to solve a variety of difficult problems encountered in modern chemical research.

Advances in Inorganic Chemistry: Heme–Fe Proteins, Vol. 51; A.G. Sykes, A.G. Mauk (Eds.); Academic Press, San Diego, 2001, xv+455 pages, ISBN 0-120-23651-6, US$ 130.00

Advances in Inorganic Chemistry: Heme–Fe Proteins, Vol. 51; A.G. Sykes, A.G. Mauk (Eds.); Academic Press, San Diego, 2001, xv+455 pages, ISBN 0-120-23651-6, US$ 130.00

A novel role for calcite in calcium homeostasis

Calcium carbonate (CaCO 3) minerals are known to be deposited in a wide array of different organisms, ranging from microbes to vertebrates [(1989) On Biomineralization, Oxford University Press, New York]. Calcite, aragonite and vaterite are the major crystalline structural polymorphs of CaCO 3 associated with living systems, and participate in a variety of biological functions [(1989) Biomineralization: Chemical and Biochemical Perspectives. VCH Publishers, Weinham, Germany; (1991) Advances in Inorganic Chemistry 36, 137–200]. Here we report on the ability of a soil bacterium to synthesize calcite in a calcium-stressed environment. The elaboration of this exocellular crystalline residue enables the organism to regulate its calcium content. The attainment of calcium homeostasis via the exocellular deposition of bacterial calcite with unique crystal habits is a novel biological phenomenon.

Advances in inorganic chemistry and radiocheistry, vol. 25

Advances in inorganic chemistry and radiocheistry, vol. 25

Book Reviews: Advances in Inorganic Chemistry and Radiochemistry. Volume 24

Book Reviews: Advances in Inorganic Chemistry and Radiochemistry. Volume 24

A Review of: “Advances in Inorganic Chemistry and Radiochemistry, Volume 24, H. J. Emeleus and A. G. Sharpe, Editors, Academic Press, New York, 1981. viii + 372 pages, cloth, $46.00”

A Review of: “Advances in Inorganic Chemistry and Radiochemistry, Volume 24, H. J. Emeleus and A. G. Sharpe, Editors, Academic Press, New York, 1981. viii + 372 pages, cloth, $46.00”

A Review of: “Advances in Inorganic Chemistry and Radiochemistry. Vol. 24. Editors H. J. Emeleus and A. G. Sharpe, Academic Press, New York, 1981, VII + 372 pages, $46.00”

A Review of: “Advances in Inorganic Chemistry and Radiochemistry. Vol. 24. Editors H. J. Emeleus and A. G. Sharpe, Academic Press, New York, 1981, VII + 372 pages, $46.00”

A Review of: “Advances in Inorganic Chemistry and Radiochemistry, Volume 20. Edited by H. J. Emeléus and A. G. Sharpe. Academic Press, New York, N. Y., 1977. vii + 374 pp. $38.00”

A Review of: “Advances in Inorganic Chemistry and Radiochemistry, Volume 20. Edited by H. J. Emeléus and A. G. Sharpe. Academic Press, New York, N. Y., 1977. vii + 374 pp. $38.00”

A review of: “Advances in Inorganic Chemistry and Radiochemistry. Edited by H. J. Emeleus and A. G. Sharpe, Academic Press, New York, San Francisco, London, 1976, 414 pp., $35.50”

A review of: “Advances in Inorganic Chemistry and Radiochemistry. Edited by H. J. Emeleus and A. G. Sharpe, Academic Press, New York, San Francisco, London, 1976, 414 pp., $35.50”

Book Review: Advances in Inorganic Chemistry and Radiochemistry. Vol. 7. Edited by H. Emeléus and A. Sharpe

Book Review: Advances in Inorganic Chemistry and Radiochemistry. Vol. 7. Edited by H. Emeléus and A. Sharpe

Book Review: Advances in Inorganic Chemistry and Radiochemistry. Vol. 6. Edited by H. J. Emeléus and A. G. Sharpe

Book Review: Advances in Inorganic Chemistry and Radiochemistry. Vol. 6. Edited by H. J. Emeléus and A. G. Sharpe

Book Review: Advances in Inorganic Chemistry and Radiochemistry, Vol. 5. Edited by H. J. Emeléus and A. G. Sharpe

Book Review: Advances in Inorganic Chemistry and Radiochemistry, Vol. 5. Edited by H. J. Emeléus and A. G. Sharpe

Advances in Inorganic Chemistry and Radiochemistry. Volume 5. Edited by H. J. Emeléus and A. G. Sharpe

Advances in Inorganic Chemistry and Radiochemistry. Volume 5. Edited by H. J. Emeléus and A. G. Sharpe