Accurately mapping lithological features is essential for geological surveys and the exploration of mineral resources. Remote-sensing images have been widely used to extract information about mineralized alteration zones due to their cost-effectiveness and potential for being widely applied. Automated methods, such as machine-learning algorithms, for lithological mapping using satellite imagery have also received attention. This study aims to map lithologies and minerals indirectly through machine-learning algorithms using advanced spaceborne thermal emission and reflection radiometer (ASTER) remote-sensing data. The capabilities of several machine-learning (ML) algorithms were evaluated for lithological mapping, including random forest (RF), support vector machine (SVM), gradient boosting (GB), extreme gradient boosting (XGB), and a deep-learning artificial neural network (ANN). These methods were applied to ASTER imagery of the Sar-Cheshmeh copper mining region of Kerman Province, in southern Iran. First, several spectral features that were extracted from ASTER bands were used as input data. Second, correlation coefficients between the original spectral bands and features were extracted. The importance of the random forest features (RF’s feature importance) was subsequently computed, and features with less importance were removed. Finally, the remained features were given to the models as input data in the second scenario. Accuracy assessments were performed for lithological classes in the study region, including Sar-Cheshmeh porphyry, quartz eye, late fine porphyry, hornblende dike, granodiorite, feldspar dike, biotite dike, andesite, and alluvium. The overall accuracy results of lithological mapping showed that ML-based algorithms without feature extraction have the highest accuracy. The overall accuracy percentages for ML-based algorithms without conducting feature extraction were 84%, 85%, 80%, 82%, and 80% for RF, SVM, GB, XGB, and ANN, respectively. The results of this study would be of great interest to geologists for lithological mapping and mineral exploration, particularly for selecting appropriate ML-based techniques to be implemented in similar regions.