Advances In Optical Technology Research Articles

Mitochondria of T Lymphocytes Promote Anti-Pulmonary Tumor Immune Response.

B-cell lymphoma 2 (Bcl-2), a protein involved in apoptosis, has been proven to have carcinogenic potential and is well documented. With the recent advancement in optical technology, it has become possible to observe subcellular organelles such as mitochondria in real-time without the need for staining. Consequently, we have examined the movement of mitochondria in cancer cells, correlating it with the regulation of Bcl-2. Using a tomographic microscope, which can detect the internal structure of cells, we observed lung tumor cells. Cells were exposed to a laser beam (λ = 520 nm) inclined at 45°, and holographic images were recorded up to a depth of 30 µm of reconstruction. Intriguingly, lung tumor cells rapidly expelled mitochondria upon the attachment of Bcl-2 or B-cell lymphoma extra-large (Bcl-xL) inhibitors. On the other hand, we observed that tumor cells hijack mitochondria from T cells. The hijacked mitochondria were not immediately linked to tumor cell death, but they played a role in assisting granzyme B-induced tumor cell death. Due to lower levels of Bcl-2 and Bcl-xL on the mitochondria of T cells compared to lung tumor cells, immune cells depleted of Bcl-2 and Bcl-xL were co-cultured with the tumor cells. As a result, a more effective tumor cell death induced by granzyme B was observed. Additionally, further enhanced anticancer immune response was observed in vivo. Together, we show that modified mitochondria of T cells can provide potential novel strategies towards tumor cell death.

Online Orientation Recognition of Single-Crystal Diamond Tools in the Process of Indexing Grinding Based on HMM and Multi-Information Fusion

Single-crystal diamond tools occupy an important position in the field of optical processing as the basis and key to advanced optical manufacturing technology, such as grating manufacturing and optical mirror-turning processing. Single-crystal diamond tools have become the cornerstone of the development of related industries. This paper takes a single-crystal diamond arc tool as the research object. Sound signal analysis technology and vibration signal analysis technology are comprehensively applied to the online orientation identification of a single-crystal diamond tool in the indexing grinding process. The online orientation method of the tool is explored, the sound signal and the vibration signal are taken as the characteristic signals, and a wavelet algorithm (WT) is used to reduce the noise of the vibration signal and sound signal. The kurtosis of the sound signal and the kurtosis and skewness of the vibration signal in the high-order statistics strongly related to the grinding direction of a single-crystal diamond are used as the characteristic parameters, and the online direction recognition model of the tool is established using the Hidden Markov Method (HMM). The above characteristic parameters are used as model input for multi-information fusion. The mapping relationship between the characteristic parameters of the characteristic signal and the crystal orientation of the single-crystal diamond crystal face is obtained, and then the online orientation method of the single-crystal diamond arc tool in the process of indexing grinding is formed. The effectiveness of the method is verified by experiments, and effective orientation information is provided for research on the positioning control strategy of the tool grinding process to ensure the efficiency of grinding and improve the manufacturing level of the tool.

Thermal stress simulation analysis of aerospace optical fibers and connectors and related extensions to high-speed railway area

Aerospace optical cables and fiber-optic connectors have numerous advantages (e.g., low loss, wide transmission frequency band, large capacity, light weight, and excellent resistance to electromagnetic interference). They can achieve optical communication interconnections and high-speed bidirectional data transmission between optical terminals and photodetectors in space, ensuring the stability and reliability of data transmission during spacecraft operations in orbit. They have become essential components in high-speed networking and optically interconnected communications for spacecrafts. Thermal stress simulation analysis is important for evaluating the temperature stress concentration phenomenon resulting from temperature fluctuations, temperature gradients, and other factors in aerospace optical cables and connectors under the combined effects of extreme temperatures and vacuum environments. Considering this, advanced optical communication technology has been widely used in high-speed railway communication networks to transmit safe, stable and reliable signals, as high-speed railway optical communication in special areas with extreme climates, such as cold and high-temperature regions, requires high-reliability optical cables and connectors. Therefore, based on the finite element method, comprehensive comparisons were made between the thermal distributions of aerospace optical cables and J599III fiber optic connectors under different conditions, providing a theoretical basis for evaluating the performance of aerospace optical cables and connectors in space environments and meanwhile building a technical foundation for potential optical communication applications in the field of high-speed railways.

Predictive dynamic modeling and analysis of blisks through digital representations constructed upon precise geometry measurements

Blade geometric variations generally have a significant impact on the structural dynamics of integrally bladed disks widely used in the advanced aero-engines. This paper presents a holistic research in regard to the predictive dynamic modeling, analysis and experimental verification for a blisk by taking advantage of the advanced 3D optical geometry measurement technology. Geometrically mistuned models (GMMs) are semi-automatically constructed upon the precisely measured blisk geometry by an efficient FE mesh updating strategy. They provide explicit, high-fidelity digital representations of the geometric variations within the integrally manufactured blisk. A ‘Sector Mode Assembling Reduction Technique’ is developed and specifically tailored for efficient dynamic analysis of the large-sized GMMs at a relatively low computational cost and memory requirement. Intensive test campaigns, including forced response tests in the stationary/spinning rig under well-controlled laboratory conditions, are carried out for a full assessment of the GMMs’ dynamic prediction capability. Experimental verification results show that the GMM is able to capture the modal dynamics and resonant vibration of the stationary/rotating blisk with satisfactory accuracy. The physical-reality-based GMM converted directly from the precise geometry measurement data can be considered as a viable and valuable tool for predictive vibration evaluation of blisks. However, its model accuracy exhibits a mode-related dependence on the mesh density. The tradeoff between model accuracy and prohibitive computational cost proved to be the bottleneck of this promising blisk modeling approach.

Research progress and development trends of hydrogen explosion suppression materials and mechanisms

In order to effectively control and reduce the destructive effects caused by hydrogen leakage and explosion accidents, continuously improving the theoretical system of hydrogen suppression. Based on a survey of literature, this article reviews and discusses the current research status of hydrogen explosion characteristics, explosion suppression materials, and explosion suppression mechanisms. In terms of research on hydrogen explosion characteristics, the impact of initial conditions on macroscopic parameters such as explosion limit, explosion pressure and flame propagation speed were mainly studied. In terms of research on hydrogen suppression, summarizes the research progress of hydrogen explosion suppression materials in recent years from five aspects: inert gas, water mist, solid powder, halogenated hydrocarbons and composite suppression. The suppression effects and suppression mechanisms of different materials were comparatively analyzed. The analysis found that the explosion suppression mechanism of inert gas is mainly physical inerting, and a higher concentration of inert gas is required to completely suppress hydrogen explosion. The explosion suppression mechanism of fine water mist is mainly evaporation and heat absorption, but it cannot completely suppress lean fuel hydrogen explosion. Solid powder materials have almost no inhibitory effect on hydrogen explosion. The explosion suppression mechanism of halogenated hydrocarbons is mainly to eliminate H radicals, but halogenated hydrocarbons have an promoting effect on lean fuel hydrogen. The suppression effect of composite explosion suppressants is better than that of a single explosion suppressor. However, there are currently few studies on the suppression of hydrogen explosions by composite suppressants, and the mechanism of explosion needs to be improved. The article proposes that hydrogen absorption materials, eliminate H radical targeted suppression materials and composite explosion suppression materials are the focus of research on hydrogen suppression materials. Using advanced optical diagnostic technology to study the concentration of radicals and explosion flow field characteristics, and using kinetic simulation software to reveal the complex chain reaction process are important means to study the mechanism of hydrogen explosion suppression. Large-scale explosion suppression experiments are more instructive for engineering applications, but there is a lack of large-scale equipment and experimental research.

Phase Control and Singlet Energy Transfer Enabled by Trimethylamine Modified Boron Dipyrromethene for Stable CsPbBr3 Quantum Wells

AbstractThe phase distribution and organic spacer cations play pivotal roles in determining the emission performance and stability of perovskite quantum wells (QWs). Here, we propose a universal molecular regulation strategy to tailor phase distribution and enhance the stability of CsPbBr3 QWs. The capability of sterically hindered ligands with formidable surface binding groups is underscored in directing CsPbBr3 growth and refining phase distribution. With trimethylamine modified boron dipyrromethene (BDP‐TMA) ligand as a representative, the BDP‐TMA driven can precisely control phase distribution and passivate defects of CsPbBr3. Notably, BDP‐TMA acts as a co‐spacer organic entity in obtained BDP‐TMA‐CsPbBr3, facilitating efficient singlet energy transfer and tailoring the luminescence to produce a distinctive bluish‐white emission. The BDP‐TMA‐CsPbBr3 demonstrates significant phase stability under water exposure, light irradiation, and moderate temperature. Interestingly, BDP‐TMA‐CsPbBr3 exhibits the thermally‐induced dynamic fluorescence control at elevated temperatures, which can be achieved feasible for advanced information encryption. This discovery paves the way for the exploration of perovskite QWs in applications like temperature sensing, anti‐counterfeiting, and other advanced optical smart technologies.

Phase Control and Singlet Energy Transfer Enabled by Trimethylamine Modified Boron Dipyrromethene for Stable CsPbBr3 Quantum Wells.

The phase distribution and organic spacer cations play pivotal roles in determining the emission performance and stability of perovskite quantum wells (QWs). Here, we propose a universal molecular regulation strategy to tailor phase distribution and enhance the stability of CsPbBr3 QWs. The capability of sterically hindered ligands with formidable surface binding groups is underscored in directing CsPbBr3 growth and refining phase distribution. With trimethylamine modified boron dipyrromethene (BDP-TMA) ligand as a representative, the BDP-TMA driven can precisely control phase distribution and passivate defects of CsPbBr3 . Notably, BDP-TMA acts as a co-spacer organic entity in obtained BDP-TMA-CsPbBr3 , facilitating efficient singlet energy transfer and tailoring the luminescence to produce a distinctive bluish-white emission. The BDP-TMA-CsPbBr3 demonstrates significant phase stability under water exposure, light irradiation, and moderate temperature. Interestingly, BDP-TMA-CsPbBr3 exhibits the thermally-induced dynamic fluorescence control at elevated temperatures, which can be achieved feasible for advanced information encryption. This discovery paves the way for the exploration of perovskite QWs in applications like temperature sensing, anti-counterfeiting, and other advanced optical smart technologies.

Wafer‐Scale Manufacturing of Near‐Infrared Metalenses

AbstractMetalenses have revolutionized optical technologies with their superior ability to manipulate light and the potential to replace conventional, bulky optical components. However, their commercialization is hindered by limitations in conventional manufacturing techniques, such as small patterning areas, low throughput, and high cost. In this study, two methods are introduced for scalable and wafer‐scale manufacturing of metalenses operating in the near‐infrared region, aimed at overcoming the abovementioned challenges. The first type of metalens is polarization‐independent and constructed using hydrogenated amorphous silicon cylindrical structures fabricated through direct photolithography. This metalens has a diameter of 1 cm and numerical aperture (NA) of 0.53. The focusing efficiency is confirmed at a 940 nm wavelength, and the focal spot profile approaches the diffraction limit. The second metalens is polarization‐dependent and fabricated using silicon nanoparticle‐embedded‐resin rectangular structures through a cost‐effective nanoimprinting method. This process can produce metalenses with a diameter of 5 mm and an NA of 0.53. Both types of metalenses demonstrate high‐resolution capabilities when imaging a 1951 USAF resolution test target and bioimaging. This research offers innovative pathways for the mass production and large‐scale fabrication of metalenses. It is believed that the work will accelerate the industrialization of metalenses, fostering further advances in optical technology.

The State-of-the-Art and Perspectives of Laser Ablation for Tumor Treatment.

Tumors significantly impact individuals' physical well-being and quality of life. With the ongoing advancements in optical technology, information technology, robotic technology, etc., laser technology is being increasingly utilized in the field of tumor treatment, and laser ablation (LA) of tumors remains a prominent area of research interest. This paper presents an overview of the recent progress in tumor LA therapy, with a focus on the mechanisms and biological effects of LA, commonly used ablation lasers, image-guided LA, and robotic-assisted LA. Further insights and future prospects are discussed in relation to these aspects, and the paper proposed potential future directions for the development of tumor LA techniques.

Pressure-induced tuning of physical properties in high-throughput metal halide MSn2Br5 (M = K, Cs) perovskites for optoelectronic applications.

The physical properties of the ferromagnetic oxide perovskites MSn2Br5 (M = K, Cs) were thoroughly examined using the GGA + PBE formalism of density functional theory. The investigation includes a comprehensive characterization of these materials under hydrostatic pressures ranging up to 25 GPa. Our work represents the first theoretical framework for exploring the behavior of MSn2Br5 (M = K, Cs) under pressure, providing valuable insights into their properties. To ensure the thermodynamic and mechanical stability of the studied compounds, we justified their stability through the analysis of formation energy and Born stability criteria. Furthermore, we conducted a thorough examination of the mechanical features of MSn2Br5 (M = K, Cs) based on various parameters, such as elastic constants, elastic moduli, the Kleinman parameter, the machinability index, and the Vickers hardness. Pugh's ratio and Poisson's ratio data show a ductile behavior for both compounds under stress. Moreover, our analysis of the refractive index suggests that both materials hold significant potential as candidates for ultrahigh-density optical data storage devices, particularly when subjected to appropriate laser irradiation. This finding opens up exciting possibilities for utilizing MSn2Br5 (M = K, Cs) in advanced optical technologies.

Advanced optical diagnostic technology application progress in combustion testing of energetic materials

Advanced optical diagnostic technology application progress in combustion testing of energetic materials

Circular dichroism in two-dimensional BC6N and B3C2N3 in absence of intervalley excitonic coupling

Two-dimensional (2D) noncentrosymmetric systems offer potential opportunities for exploiting the valley degrees of freedom for advanced information processing, owing to non-zero Berry curvature. However, such valley polarization in 2D materials is crucially governed by the intervalley excitonic scattering in momentum space due to reduced electronic degrees of freedom and consequent enhanced electronic correlation. Here, we study the valley excitonic properties of two 2D noncentrosymmetric complementary structures, namely, BC6N and B3C2N3 using first principles-based GW calculations combined with the Bethe–Salpeter equation, that brings the many-body interactions among the quasiparticles. The k-resolved oscillator strength of their first bright exciton indicates their ability to exhibit valley polarization under the irradiation of circularly polarized light of different chiralities. Both the systems show significant singlet excitonic binding energies of 0.74 eV and 1.31 eV, respectively. Higher stability of dark triplet excitons as compared to the singlet one can lead to higher quantum efficiency in both the systems. The combination of large excitonic binding energies and the valley polarization ability with minimal intervalley scattering make them promising candidates for applications in advanced optical devices and information storage technologies.

Sb2S3-based optical switch exploiting the Brewster angle phenomenon [Invited

Optical switches based on phase change materials (PCMs) hold great promise for various photonic applications such as telecommunications, data communication, optical interconnects, and signal processing. Their non-volatile nature as well as rapid switching speeds make them highly desirable for developing advanced and energy-efficient optical communication technologies. Ongoing research efforts in exploring new PCMs, optimizing device designs, and overcoming existing challenges are driving the development of innovative and high-performance optical switches for the next generation of photonics applications. In this study, we design and experimentally demonstrate a novel optical amplitude switch design incorporating PCM antimony trisulfide (Sb2S3) based on the Brewster angle phenomenon.

Impact of forced convective heat transfer on temperature uniformity and frequency doubling efficiency in large aperture ammonium dihydrogen phosphate (ADP) crystals

With advancements in optical technology, the large-aperture ADP crystals have grown significantly used in high-power laser systems. Ensuring their optimal performance in such applications necessitates effective control over the temperature uniformity of crystals, this research primarily delves into the influence of forced convective heat transfer on the temperature uniformity of ADP crystals and examines the subsequent effects on the frequency-doubling efficiency of crystals. Thus, this study developed a fan-forced convective heating scheme that was tailored for large-aperture ADP crystals and scrutinized pivotal factors impacting the temperature distribution of the crystal. By integrating numerical simulations with experimental approaches, the flow field and temperature field distribution patterns were discerned at varying fan tilt angles. Additionally, the distribution of the crystal's frequency doubling efficiency was determined. The results showcased that with a fan tilt angle set at 30.0°, the ADP crystal's temperature uniformity achieved a measure of 0.03 °C, and the frequency doubling conversion efficiency peaked at 87.0 %. A reduction in the cavity length to 800 mm further refined the crystal's temperature uniformity, bringing it down to 0.02 °C. This study demonstrated that forced convection can markedly augment the temperature uniformity of the crystal. These insights are invaluable to the domains of optical applications and crystal engineering, paving the way for enhanced performance and application of ADP crystals in controlled nuclear fusion reaction devices.

Near-Infrared Transillumination for Macroscopic Functional Imaging of Animal Bodies.

The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near-infrared (NIR) light to visualize intricate internal light-absorbing structures within animal bodies. By leveraging the principle of differentiation, we have extended the applicability of the Beer-Lambert law even in cases of scattering-dominant media, such as animal body tissues. This approach facilitates the visualization of dynamic physiological changes occurring within animal bodies, thereby enabling noninvasive, real-time imaging of macroscopic functionality in vivo. An important challenge inherent to transillumination imaging lies in the image blur caused by pronounced light scattering within body tissues. By extracting near-axis scattered components from the predominant diffusely scattered light, we have achieved cross-sectional imaging of animal bodies. Furthermore, we have introduced software-based techniques encompassing deconvolution using the point spread function and the application of deep learning principles to counteract the scattering effect. Finally, transillumination imaging has been elevated from two-dimensional to three-dimensional imaging. The effectiveness and applicability of these proposed techniques have been validated through comprehensive simulations and experiments involving human and animal subjects. As demonstrated through these studies, transillumination imaging coupled with emerging technologies offers a promising avenue for future biomedical applications.

Advancements in Optical Technologies for Medical Imaging and Diagnosis

Advancements in Optical Technologies for Medical Imaging and Diagnosis

Investigation of Optical Cavity Dynamics with Raman and Ytterbium-Doped Gain Media Integration

This study delves into a comprehensive examination of an optical cavity system that integrates Raman and Yb-doped gain media, with a focus on understanding their interactions. The research implies a characterization of each gain medium within the cavity while subjecting them to diverse co-pumping conditions with the other. When the Raman-lasing cavity is co-pumped by exciting the Yb-doped section, the resulting composite laser exhibits significant threshold reductions and there is an optimal co-pumping regime that enhances energy transfer from pump to Stokes. As for the complementary cavity, where the Yb-doped gain is influenced by the co-pumped Raman gain, at moderate pump powers a light-controlling-light behavior phenomenon arises. Within this regime, the 1064 nm signal suppresses the Yb-generated 1115 nm signal, suggesting potential applications in intracavity optical modulation. For higher pump levels, a cooperative effect emerges whereby both lasers mutually enhance each other. Minor variations in the primary 974 nm pump power, even by just a few milliwatts, result in significant capabilities for switching or modulating the Stokes signal. Under these conditions of mutual enhancement, the hybrid optical system validates notable improvements regarding energy transfer efficiency and threshold reduction. This research provides valuable insights into the intricate dynamics of optical cavity systems and reveals promising avenues for applications in advanced optical modulation technologies.

Preface to Special Issue on “Advanced Optical Applications and Visualization Technologies for Future Society II”

Preface to Special Issue on “Advanced Optical Applications and Visualization Technologies for Future Society II”

Kernel flow and the eye‐ brain connectome: Study design and objectives

AbstractBackgroundMore evidence suggests how the eye health may be crucial in older adults at risk of developing cognitive impairment (CI) and Alzheimer’s disease (AD). Ocular conditions and AD share several common factors, including older age behavioral and cardiometabolic disease. Poor vision can lead to reduced activation of central sensory pathways, which is associated with higher cognitive load and brain structure damage. We showed that CI is not limited to the brain but also affects the retina. However, despite recent advances in neuroimaging biomarkers (e.g., PET diagnostics), there remains a need for more readily available and affordable diagnostic testing for AD risk. While blood flow within the optic nerve head can be quantified using advanced optical imaging technologies, it is essential to measure what is going on in the brain at the same time.MethodWe propose a cross‐sectional and longitudinal, observational study evaluating structural and functional biomarkers of the retina and brain associated with AD disease risk and/or progression. The study objective is to collect structural and functional data of the retina and brain to facilitate the discovery of reliable and sensitive multimodal biomarkers of AD disease risk and/or progression. We will examine participants (N = 200) aged 55‐80; 50 cognitively healthy (CH), 50 with preclinical AD, 50 with mild CI (MCI), and 50 with mild AD. Assessments will include neuropsychological testing, medical/functional assessment, retinal imaging, brain activity, electroretinography, pupillometry, and contrast sensitivity. We will use a wearable, whole‐head coverage time‐domain functional near‐infrared spectroscopy system (Kernel Inc) to measure local changes in blood oxygenation and electroencephalography.ResultThe eye‐brain connectome is integral in understanding pathology in neurodegenerative diseases. We aim to use the eye‐brain data to develop screening and monitoring tools to identify and track AD risk and severity.ConclusionThis study will overcome limitations for performing functional brain imaging due to the lack of portability and user‐friendliness of neuroimaging devices. Our eye‐brain multimodal biomarker study could also facilitate a novel application for diagnostic assessment and therapeutic intervention to target neuroanatomical sites compromised early in AD, leading to a more robust technique to identify high‐risk individuals before cognitive decline with sufficient sensitivity and specificity.

Chemical-imaging-guided optical manipulation of biomolecules.

Chemical imaging via advanced optical microscopy technologies has revealed remarkable details of biomolecules in living specimens. However, the ways to control chemical processes in biological samples remain preliminary. The lack of appropriate methods to spatially regulate chemical reactions in live cells in real-time prevents investigation of site-specific molecular behaviors and biological functions. Chemical- and site-specific control of biomolecules requires the detection of chemicals with high specificity and spatially precise modulation of chemical reactions. Laser-scanning optical microscopes offer great platforms for high-speed chemical detection. A closed-loop feedback control system, when paired with a laser scanning microscope, allows real-time precision opto-control (RPOC) of chemical processes for dynamic molecular targets in live cells. In this perspective, we briefly review recent advancements in chemical imaging based on laser scanning microscopy, summarize methods developed for precise optical manipulation, and highlight a recently developed RPOC technology. Furthermore, we discuss future directions of precision opto-control of biomolecules.