This is the first study on the antioxidant activity and chemical analysis with PyGCMS of leave extract (B. pilosa, H. corymbosa, and P. pellucida) originating from the Sumenep regency, Indonesia. The higher yield extracts were B-1 and P-1, about 19.33% and 20.27%. The result of the DPPH test revealed that B-1 was the highest antioxidant properties, with an IC50 value of about 6.43%. The antioxidant properties were affected by the high phenolic content of B-1 (112.20%) and the absence of hydrolyzed tannins. The H-1 has higher phenolic content than B-1 but is contrarily in antioxidant activity. The carbohydrates derivatives were easier extracted in aqua dest extract has decreased antioxidant activity at H-1. In addition, as reported by GCMS, PyGCMS also showed terpenoid compounds, tannins, and flavonoids. The interaction between compounds in plant extracts plays a more critical role in antioxidant activity than certain compounds. B-1 extract has the potential as an antioxidant additive in the food, cosmetic, or advanced materials industry