ABSTRACT Research into immigrant wellbeing and health has yielded evidence for both potential risks and the capacity for resilience of individuals moving to the United States. Limited research, though, has considered how immigrants may differ in their perceived commitment to a life direction and goals, known as sense of purpose. Moreover, research is needed on whether immigrants may be more likely to derive that purpose through social activism for change. The current study employed a nationwide sample of U. S. adults (N = 1973; 5.3% immigrants), who reported on their sense of purpose, activist purpose, self-rated health, and life satisfaction. Results indicated that immigrants did not significantly differ from native-born U. S. adults on levels for any of the primary variables. Sense of purpose was more strongly associated with life satisfaction for native-born than immigrant participants, although other associations were similar in magnitude across groups. Future research should further explore background predictors of sense of purpose among immigrant samples, as well as whether immigrants and native-born adults differ on alternative forms of purpose.