Adult Intelligence Scale-IV Research Articles

Gender Differences in Cognitive Function of Schizophrenia Patients

Objectives: Cognitive impairment is a fundamental symptom of schizophrenia, an often-overlooked aspect of the disorder that has gained recent attention due to its direct relation with functional outcomes and implications for medical and social costs. This study aims to investigate gender differences in cognitive function among patients with schizophrenia using Korean Wechsler Adult Intelligence Scale-IV (K-WAIS-IV).Methods: Data were collected from inpatients and outpatients treated at Presbyterian Medical Center between January 1, 2019, and December 31, 2023. Patients diagnosed with schizophrenia underwent evaluation with the K-WAIS-IV. Multivariate analysis of variance was utilized to assess cognitive differences between men and women participants, while correlation analysis was performed to explore associations between cognitive performance and clinical data.Results: Among 101 candidates, 26 male and 26 female patients were selected for analysis of their K-WAIS-IV scores and clinical data. The results revealed no statistically significant differences in cognitive function between male and female patients concerning Full-Scale Intelligence Quotient (FSIQ) and the four index scores: Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), and Processing Speed Index (PSI). A trend indicating preserved verbal intelligence relative to performance intelligence was observed. Additionally, the VCI exhibited a positive correlation with age, while both FSIQ and PSI demonstrated positive correlations with years of education.Conclusion: The findings of this investigation suggest that there are no significant differences in cognitive function between male and female patients with schizophrenia via K-WAIS-IV. Given the heterogeneity of the sample and potential limitations of the neurocognitive assessments employed, further research utilizing more targeted methodologies and sensitive measures is warranted.

Special Series on the Wechsler Adult Intelligence Scale-IV Performances in Five Asian Countries: Summary of Findings, Clinical Implications, and Future Directions.

This special series of exploratory studies compared WAIS-IV performances in five Asian countries: Japan, South Korea, Taiwan, India, and Indonesia with the U.S. The studies examined cognitive profiles across age groups to develop hypotheses on how culture can impact cognition. This summary article integrates the findings from each study to determine similarities and differences across Asian countries and proposes possible underlying cultural factors impacting cognition. In each study, raw scores corresponding to a subscale score of 10 were scored with U.S. norms across all age groups. Index scores were calculated with the adjusted scale scores. The impact of education on test performances was determined by correlating WAIS-IV scores with a ratio of educational attainment for each country with the U.S. for each age group. Findings from each country were then integrated to develop hypotheses on cultural factors that impacted cognitive profiles. East Asian countries (Japan, South Korea, Taiwan) demonstrated weaker Verbal Comprehension Index scores and stronger Processing Speed Index scores than the U.S. sample, although the latter was moderated by age. East Asian countries demonstrated stronger performances on Perceptual Reasoning versus Verbal Comprehension tests. East Asians and the Java subset of the Indonesian sample demonstrated a pattern of stronger performances in younger versus older cohorts which was significantly correlated with educational attainment. Cultural factors impacting cognition were proposed. Clinical implications of the findings were discussed and directions for future studies to examine the relationship between culture and cognition were recommended.

Indonesian WAIS-IV Cultural Research.

This study examined regional differences between Indonesians on the Wechsler Adult Intelligence Scale-IV Indonesia (WAIS-IV ID) and, in comparison, to the US. Three hypotheses were examined: a) Java will demonstrate stronger WAIS-IV ID performances than non-Java (NJ) samples. b) WAIS-IV ID performances will be correlated with educational attainment. c) Indonesians with higher levels of education will perform comparably to US samples. The WAIS-IV was translated into Bahasa Indonesia and administered to a convenience sample representative of the Indonesian population breakdown by island. Comparisons between Java and NJ samples were analyzed by analyses of covariance controlling for education attainment. Comparisons between the Indonesian and US samples were analyzed by one sample t-tests. The Java sample performed significantly higher than the NJ sample. Performances for the Java but not the NJ sample significantly correlated with educational attainment. Indonesians performed significantly lower than the US on 19/20 WAIS-IV ID subtests measures. However, the Java sample demonstrated comparable performances with the US with both countries scoring significantly higher than the other on select subtests and indexes. The Java sample demonstrated lower performances for older age cohorts with increasingly stronger scores across younger age cohorts. This pattern was paralleled by increases in educational attainment. All hypotheses were supported except for correlations between educational attainment and WAIS-IV ID performances which was significant for the Java sample but not the NJ sample. Findings were interpreted within the context of economics and educational attainment and quality.

Japanese Performance Profile on the WAIS-IV and Purported Cultural Influences.

The present exploratory study aimed to examine the potential impact of culture on cognitive skills and intelligence by comparing the Japanese Wechsler Adult Intelligence Scale-IV (WAIS-IV) (JW) subtests, IQs, and index scores to those of the U.S. WAIS-IV (USW). JW raw scores corresponding to a scaled score of 10 for each subtest were scored with USW norms. Subtest, index, and IQ scores were then calculated for each age range. The impact of education on scores was evaluated through ratio of educational attainment for each cohort of the Japanese and US samples. Japanese and US data were compared using one-sample t-tests. Correlations between subtest, index, and IQ scores and education were calculated. The USW sample performed higher than the JW sample on verbal comprehension subtests, while the JW sample demonstrated stronger performances in processing speed and perceptual reasoning subtests. However, all scores with the exception of Block Design, Matrix Reasoning, and Figure Weights were significantly associated with differential educational attainment between the two countries. Educational differences were linearly associated with age with the higher educational attainment for younger Japanese age groups and higher attainment for the older US cohorts. The present study demonstrates cognitive differences between Japan and the USA. Performance on the WAIS-IV subtest and composite measures are highly correlated with education. Cultural factors impacting the cognitive profile of the Japanese sample such as differences in worldview, customs, educational systems, and writing system, were proposed. Clinical neuropsychologists should take these aspects into account when administering and interpreting test results.

Introduction to the Special Series on the Wechsler Adult Intelligence Scale-IV Performances in Five Asian Countries Series.

Introduction to the Special Series on the Wechsler Adult Intelligence Scale-IV Performances in Five Asian Countries Series.

Wechsler Adult Intelligence Scale - IV México versus U.S. versions in the assessment of Mexican Americans.

To delineate score differences between the Wechsler Adult Intelligence Scale-IV (WAIS-IV) and the WAIS-IV México in the assessment of balanced bilingual Mexican Americans and to determine the efficacy of five hold measures in predicting summary scores in each version. Hold measures were WAIS-IV Information, Vocabulary, and Matrix Reasoning subtests, picture vocabulary, and the Test of Premorbid Function (English)/Word Accentuation Test (Spanish). Using a repeated measures design, 60 neurologically intact participants were tested in a counterbalanced order, with WAIS-IV version as the repeated measure (mean intertest interval = 5.68 days). To minimize practice effects, the five visual-perceptual subtests, which contain the same items in each version, were administered only once during the initial session. All mean WAIS-IV México index/subtest scores were significantly higher than the U.S. equivalents (Full-Scale IQ by about .5 SD). Unexpectedly, most (83%) participants educated in the US to at least a high school level had numerically equal or higher scores on the U.S. version. Means on WAIS-IV language format indices/subtests were lower than those of visual-perceptual format indices/subtests within both versions (excepting Processing Speed Index/subtests in the U.S. version). All hold measures significantly predicted WAIS-IV summary scores for the U.S. version. Similarly for the México version, except for the Word Accentuation Test. When evaluating a balanced bilingual Mexican American, opting for the WAIS-IV México version will yield higher scores across the Full-Scale IQ, indices, and all core subtests unless the patient was educated in the US to at least a high school level.

Impact of Cognitive and Psychological Functions in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional Study.

To compare the cognitive functions and trait anxiety in patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) to those of matched healthy controls (HCs). In addition, the study aims to investigate the correlations among cognitive functions, anxiety, depression, and quality of life (QOL) in this clinical population. The sample included RRMS patients (n = 21) and an equal number of age-, education-, and sex-matched HCs. Participants were assessed on the Indian version of the Wechsler Adult Intelligence Scale-IV, auditory and visual learning and memory, and visual-spatial construction and memory. RRMS patients were also assessed for levels of anxiety, depression, and their QOL. Comparative analyses between RRMS patients and HCs were carried out for neuropsychological assessments. Correlations among cognitive functions, anxiety, depression, and QOL in RRMS patients were examined. RRMS patients showed significant deficits across various cognitive domains, including processing speed and verbal learning, compared to HCs (P < 0.05). In addition, they reported higher levels of trait anxiety compared to HCs (P < 0.01), along with moderate state anxiety and mild depression. A significant correlation among anxiety, depression, and QOL was observed in RRMS patients. This study highlights significant cognitive impairments and psychological distress experienced by RRMS individuals, underscoring the critical need for comprehensive care addressing both cognitive impairments and psychological distress to enhance QOL.

Impact of Iron Intake and Reserves on Cognitive Function in Young University Students.

Iron is a key nutrient for cognitive function. During periods of high academic demand, brain and cognitive activity increase, potentially affecting iron intake and reserves. The present study aimed to investigate the impact of iron levels on cognitive function in a university sample, considering the influence of gender. A cross-sectional study was conducted with 132 university students (18-29 years) from the University of Castilla-La Mancha (Spain). A dietary record was formed through a questionnaire to analyze iron consumption, and blood and anthropometric parameters were measured. The Wechsler Adult Intelligence Scale-IV was used to determine the Intelligence Quotient (IQ), as well as the Verbal Comprehension Index (VCI), Working Memory Index (WMI), Processing Speed Index (PSI), and Perceptual Reasoning Index (PRI), to assess cognitive abilities. Among women, the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) was 21% and 4.2%, respectively. No ID or IDA was found in men. The impact of iron intake on IQ and cognitive abilities was mainly associated with the female population, where a positive association between iron intake, serum ferritin, and total IQ was revealed. In conclusion, low iron intake is related to poorer intellectual ability, suggesting that an iron-rich diet is necessary to maintain the academic level of university students.

Career and Life Development of a Gifted Student in Poverty: A Qualitative Longitudinal Case Study

This research is a qualitative study of Semi (alias), a gifted Korean male high school student living in urban poverty. Interviews with Semi 6 times for three years, 60 minutes per interview, were analyzed as a part of a longitudinal qualitative study. Semi had been overwhelmed by the harsh environment and unable to move forward. Semi was the only gifted among participants with the highest IQ (in the gifted range with Korea Wechsler Adult Intelligence Scale-Ⅳ at age 17). Although he had the highest intellectual ability among the participants, he did not have confidence in himself. And he did not achieve anything at all when he graduated high school. He spent another year to prepare the college entrance exam, but he failed and left the research for good. The qualitative data were analyed into six themes (neglected childhood, intimate, but worried father, housing instability, helpful teacher, frustrated dream of astronomer, lack of motivation to escape poverty). Among them a representative example of Semi's poor environment is housing instability and Semi's disadvantage is also revealed in that he did not meet an adult who could be a role model for life. The implications and suggestions for future research in career education and counseling were discussed.

Worry and ruminative brooding: associations with cognitive and physical health in older adults.

Mental health conditions are associated with cognition and physical function in older adults. We examined whether worry and ruminative brooding, key symptoms of certain mental health conditions, are related to subjective and/or objective measures of cognitive and physical (cardiovascular) health. We used baseline data from 282 participants from the SCD-Well and Age-Well trials (178 female; agemean = 71.1 years). We measured worry and ruminative brooding using the Penn State Worry Questionnaire and the Ruminative Response Scale-brooding subscale. We assessed subjective physical health using the WHOQOL-Bref physical subscale, and objective physical health via blood pressure and modified versions of the Framingham Risk Score and Charlson Comorbidity Index. With subjective and objective cognition, we utilized the Cognitive Difficulties Scale and a global composite (modified Preclinical Alzheimer's Cognitive Composite, PACC5, with the Wechsler Adult Intelligence Scale-IV, category fluency, Mattis Dementia Rating Scale-2, and either the California Verbal Learning Test or the Rey Auditory Verbal Learning Test). We conducted linear regressions, adjusted for education, age, sex and cohort. Worry and ruminative brooding were negatively associated with subjective physical health (worry: β = -0.245, 95%CI -0.357 to -0.133, p < 0.001; ruminative brooding: β = -0.224, 95%CI -0.334 to -0.113, p < 0.001) and subjective cognitive difficulties (worry: β = 0.196, 95%CI 0.091 to 0.302, p < 0.001; ruminative brooding: β = 0.239, 95%CI 0.133 to 0.346, p < 0.001). We did not observe associations between worry or ruminative brooding and any measure of objective health. Worry and ruminative brooding may be common mechanisms associated with subjective but not objective health. Alternatively, cognitively unimpaired older adults may become aware of subtle changes not captured by objective measures used in this study. Interventions reducing worry and ruminative brooding may promote subjective physical and cognitive health; however, more research is needed to determine causality of the relationships.

Speed of processing training to improve cognition in moderate to severe TBI: a randomized clinical trial.

Moderate to severe traumatic brain injury (TBI) often results in cognitive deficits. Processing speed (PS) deficits are common, exerting a significant impact on daily life. Few studies have examined the efficacy of cognitive rehabilitation specifically for PS deficits in moderate to severe TBI. Examine the efficacy of Speed of Processing Training (SOPT) in moderate to severe TBI. This protocol is a 10-session behavioral intervention for PS deficits that has been successfully used with other cognitively impaired populations. This double-blind, placebo-controlled, randomized clinical trial included 46 participants with moderate to severe TBI, 22 randomly assigned to the treatment group and 24 to the placebo-control group. Baseline and follow-up measures included a task similar to the training task (UFOV), measures of near transfer (neuropsychological measures of processing speed: Symbol Digit Modalities Test (SDMT), Wechsler Adult Intelligence Scale-IV (WAIS-IV) Symbol Search, WAIS-IV Coding) and measures of far transfer [neuropsychological measures of learning and memory: the California Verbal Learning Test-II (CVLT-II), Memory Assessment Scales - Prose Memory (MAS-PM)]. Significant improvement from pre-to post-SOPT was observed on all subtests of the UFOV, which is similar to the training task. There was no significant difference on neuropsychological measures of PS or new learning and memory post-treatment. Neuropsychological assessment 6-months post-treatment showed no significant change in PS ability over time. Monthly booster sessions did not impact performance at the 6-month follow-up. Consistent with the SOPT literature, SOPT improves PS ability as measured by the UFOV, a task similar to the training task, in moderate to severe TBI. However, neither near nor far transfer was noted. That is, no improvement was noted on neuropsychological measures of PS.

Exploring the Potential of the Corpus Callosum Area as a Predictive Marker for Impaired Information Processing in Multiple Sclerosis

Early cognitive impairment (CI) detection is crucial in multiple sclerosis (MS). However, it can progress silently regardless of relapse activity and reach an advanced stage. We aimed to determine whether the corpus callosum area (CCA) is a sensitive and feasible marker for CI in MS compared to other neuroimaging markers. We assessed cognitive function in 77 MS patients using the Symbol Digit Modalities Test, Paced Auditory Serial Additions Task, Wechsler Adult Intelligence Scale-IV, and Wechsler Memory Scale-Revised. The neuroimaging markers included manually measured CCA, two diffusion tensor imaging markers, and nine volumetric measurements. Apart from volumes of the hippocampus and cerebellum, ten markers showed a significant correlation with all neuropsychological tests and significant differences between the groups. The normalized CCA demonstrated a moderate-to-strong correlation with all neuropsychological tests and successfully differentiated between the CI and cognitively normal groups with 80% sensitivity and 83% specificity. The marker had a large area under the curve and a high Youden index (0.82 and 0.63, respectively) and comparability with established cognitive markers. Therefore, the normalized CCA may serve as a reliable marker for CI in MS and can be easily implemented in clinical practice, providing a supportive diagnostic tool for CI in MS.

17 Comparing Cognitive Patient-Reported Outcomes with Neuropsychological Impairment in Patients with Diffuse Glioma.

Objective:Cognitive difficulties among diffuse glioma survivors are common in survivorship due to cancer treatment effects (i.e., surgery, chemotherapy, and/or radiation therapy), which can diminish quality of life. Routine monitoring of cognitive symptoms in survivorship is recommended and can help address patient needs and inform clinical interventions (e.g., cognitive rehabilitation). While several patient-reported outcome (PRO) measures have been used in brain tumor populations, there has been few studies comparing the performance of these PROs in patients with diffuse glioma. In order to better understand the value of different PROs, we conducted preliminary analyses associating cognitive PROs with neuropsychological impairment in a well-characterized sample of patients with diffuse glioma.Participants and Methods:23 glioma patients (mean aged 44.26 ± 12.24), six or more months after completing cancer treatment, underwent comprehensive psychosocial and neuropsychological assessments. The neuropsychological battery included the Hopkins Verbal Learning Test - Revised, Brief Visuospatial Memory Test - Revised, Wechsler Adult Intelligence Scale-IV tests of Coding and Digit Span, Trail-Making Test, Stroop Test, FAS, Animals, Boston Naming Test, and Rey-Osterrieth Complex Figure (copy). Completed cognitive PROs included the Functional Assessment of Cancer - Cognitive Function and Brain questionnaires (FACT-Cog; FACT-Br), the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire for Brain Neoplasms (EORTC QLQ-BN20), and the Multidimensional Fatigue Symptom Inventory, short form (MFSI-SF) Mental subscale. Based on published norms, we divided the sample into cognitively impaired and non-impaired groups (two or more primary neuropsychological test scores &lt;= -2 z-score). We compared PRO scores between impaired and non-impaired groups using Mann-Whitney U tests. Higher medians equate to better cognitive functioning for all PROs, except for the MSFI-SF.Results:We found significantly worse scores in the impaired group compared to non-impaired group on the FACT-Cog subscales of perceived cognitive ability (PCA), [Non-Impaired (Mdn = 21, n = 11), Impaired (Mdn = 10, n = 12), U = 22.5, z = -2.68, = 0.007], perceived cognitive impairment (PCI), [Non-Impaired (Mdn = 59, n = 11), Impaired (Mdn = 44, n = 12), U = 32.5, z = -2.06, p=0.039]. The impaired group also trended towards worse scores on the FACT-Br additional concerns subscale [Non-Impaired (Mdn = 79.5, n = 10), Impaired (Mdn = 61, n = 12), U = 32.5, z = -1.81, p=0.07]. Group differences were not observed on the MSFI-SF [Non-Impaired (Mdn = 5, n = 11), Impaired (Mdn = 7, n = 12), U = 40.5, z = -1.57, p=0.12], or EORTC Cognitive Functioning subscale [Non-Impaired (Mdn = 83.33, n = 10), Impaired (Mdn = 75, n = 12), U = 42, z = -1.23, p=0.218].Conclusions:The preliminary findings suggest that the FACT-Cog, especially the PCA and PCI correspond with neuropsychological impairment among diffuse glioma survivors better than other cognitive PROs. The FACT-Br subscale was somewhat effective. The MFSI-SF Mental and EORTC Cognitive Functioning subscales did not correspond to impairment status. The FACT-Cog is a promising instrument and future work is needed to better determine relative utility of cognitive PROs in this population.

74 The Impact of Motoric Dysfunction on Neuropsychological Test Performance Within an Electrical Injury Sample

Objective:Victims of electrical injury (EI) often experience injuries to the peripheral nervous system and neuromuscular damage that may diminish motor function, such as flexibility/dexterity. These difficulties may continue after rehabilitation due to the reorganization of muscle afferent projections during peripheral nerve regeneration. Therefore, understanding how patients with a history of thermal burn injuries perform on motoric measures is necessary to explain the impact neuromuscular damage has on both motor and non-motor tests of cognition. However, no studies have examined the impact of motor functioning on cognition in patients who experienced thermal and electrical injuries compared to an electrical shock injury. This study explored the impact of motor dysfunction and psychiatric distress measured by depression severity on psychomotor speed and executive test performances among EI patients with and without thermal burn injuries.Participants and Methods:This cross-sectional study consisted of EI patients undergoing an outpatient neuropsychological evaluation, including tests of motor dexterity (Grooved Pegboard [GP]), psychomotor speed (Wechsler Adult Intelligence Scale-IV Coding, Trail Making Test [TMT] Part A), and executive functioning (Stroop Color and Word Test [SCWT] Color-Word trial, TMT Part B). The sample was 83% male and 17% female, 88% White, 3% Black, 5% Hispanic, and 2% other race/ethnicity, with a mean age of 43.9 years (SD=11.36), mean education of 12.9 years (SD=2.05), and mean depression severity of 20.05 (SD=12.59) on the Beck Depression Inventory-II (BDI-II). Exclusion criteria were: 1) injury history of moderate-to-severe head trauma, 2) &gt;2 performance validity test failures, and 3) any amputation of the upper extremity. Regression analyses included GP T-Scores for dominant hand and BDI-II total score as independent variables and neuropsychological normative test data as dependent variables.Results:Among validly performing patients with EI (n=86), regression analyses revealed GP performance accounted for significant variance (R2 =.153-.169) on all neuropsychological measures. Among EI patients with burn injuries (n=50), regression analyses revealed GP performance accounted for significant variance (R2 =.197-.266) on all neuropsychological measures. Among EI patients without burn injuries (n=36), analyses revealed that neither GP performance nor BDI-II severity accounted for significant variance across the neurocognitive tests (R2=.056-.142). Furthermore, among EI patients with burn injuries and the total sample, regression analyses revealed depression severity negatively predicted GP performance (R2 =.099-.13), however, in patients without burn injuries, depression did not predict GP performance (R2 =.052).Conclusions:Overall, results showed that GP performance is a significant predictor of neurocognitive performance on both motor and non-motor measures in EI patients with burn injuries. Therefore, among EI patients with burn injuries, GP performance may have potential utility as an early indicator of injury severity, considering that it predicts neuropsychological test performance on measures of psychomotor speed and executive functioning. Lastly, depression predicted GP performance within the burn injury sample illustrating that psychological distress may negatively impact motor functionality.

2 Validity and Reliability of Mobile Toolbox Cognitive Assessments

Objective:To present validation evidence for the first eight cognitive measures available through Mobile Toolbox (MTB). These measures use a remote self-administered platform to assess language, working memory, episodic memory, executive function, and processing speed.Participants and Methods:We used two separate samples, recruited as part of a larger study, to validate MTB measures. Sample I, comprised of 92 English-speaking adults ages 18-85, was used to assess internal consistency and construct validity. Participants were first administered “gold standard” cognitive measures (Wechsler Memory Scale-IV Verbal Paired Associates I and II; Wechsler Adult Intelligence Scale-IV Symbol Search, Digit Span, Coding, and Letter-Number Sequencing; Delis-Kaplan Executive Function System Color-Word Interference Test, Peabody Picture Vocabulary Test, Wechsler Individual Achievement Test-4 Spelling, and the Wisconsin Card Sorting Test), after which they completed MTB (pre-loaded on a study-provided smartphone) on their own. Internal consistency was evaluated using measure-appropriate indices (split-half reliability, Cronbach’s alpha or IRT-based indices). Pearson correlation coefficients between MTB tests and measures of similar constructs were used to evaluate concurrent validity. For two tests with timing-dependent scores, Arrow Matching and Shape-Color Sorting, separate analyses were performed for iOS and Android devices. Sample II, with 1,120 English-speaking participants ages 18-90, was used to evaluate age-related change. Participants completed MTB measures remotely on their own smartphones, in a preset order, within a 14-day period. Spearman correlation coefficients, corrected for education, were calculated to evaluate relationships between age and test scores.Results:Sample I participants were 67% female, 52% white, 99% non-Hispanic; average age=48 (SD= 17). Education was: &lt; high school (1%); high school (55%); some college (21%); college (15%); graduate degree (8%). Internal consistency estimates ranged from 0.81 to 0.99. Pearson correlations between MTB and external measures ranged from 0.41 to 0.86 (all p &lt; .01). Of the timed tests, only Shape-Color sorting showed significant score differences between Android and iOS devices. Sample II was 57% female, 13% Hispanic, 72% white, mean age = 45 (SD = 21). Education distribution was: &lt; high school (2%); high school (34%); some college (34%), college (20%); graduate degree (11%). Measures of executive function (r = -0.50; r=-0.57) and processing speed (r= -0.61) showed the expected negative correlation with age (all p &lt;0.001). Negative correlations, although weaker, were also seen on measures of working memory (r=-0.2) and episodic memory (r=-0.2, r=-0.37; p.&lt;.001). Vocabulary performance improved with age (r=0.4; p&lt;.001), while spelling scores remained stable (r=0.09).Conclusions:Initial studies support the validity and reliability of the first eight MTB cognitive measures in two diverse samples. MTB tests showed satisfactory construct validity, as demonstrated by the associations between MTB and well-established tests. Furthermore, most MTB measures correlated with age in the expected directions. Executive function, processing speed and memory typically decrease with age and this decrease was reflected in MTB test performance. In contrast, spelling and vocabulary, typically preserved as we age, did not decrease in our sample. Our results support the use of MTB in cognitive aging research.

42 Associations Between Mild Traumatic Brain Injury, Executive Function, and Criminal Justice Involvement among Veterans and Service Members: a LIMBIC-CENC study

Objective:To examine relationships between history of mild traumatic brain injury (mTBI), neuropsychological measures of executive function, and lifetime history of criminal justice (CJ) involvement among combat-exposed Veterans and Service Members (V/SM).Participants and Methods:Participants were combat-exposed V/SM who completed a baseline assessment for the multicenter Long-term Impact of Military-Relevant Brain Injury Consortium - Chronic Effects of Neurotrauma Consortium study (N=1,341) and had adequate engagement/symptom reporting on measures of performance and symptom validity (i.e., Medical Symptom Validity Test and Mild Brain Injury Atypical Symptoms Scale). Neuropsychological battery included the Trail Making Test (A and B), Wechsler Adult Intelligence Scale-IV (WAIS-IV) Digit Span subtest, and the National Institute of Health (NIH) Toolbox Flanker subtest. Lifetime history of brain injury, criminal justice involvement, and demographics were collected. Participants were 87% male, 72% white, with a mean age of 40 years (SD=9.67). Eighty-one percent had at least some college education. Nineteen percent were active duty. Eighty percent of Veterans and 86% of Service Members reported a history of &gt;1 mTBI, and of these 31% and 47% respectively experienced 3+ mTBIs.Results:Three groups were composed based on level of involvement with the CJ system: 1.) No history of arrests or incarcerations (3+ mTBIs: 64%), 2.) A lifetime history of arrest but no felony incarceration (3+ mTBIs: 34%), and 3.) A lifetime history of felony incarceration (3+ mTBIs: 2%). Ordinal regression analyses revealed that performance on a working memory task (Digit Span; b= 0.024, p= .041; OR= 1.024) was significantly associated with increased CJ involvement after adjusting for age, education, service status, and mTBIs. Performance on measures of processing speed (Trails A), set-shifting (Trails B), and inhibition (Flanker) were not significantly associated with CJ involvement. Number of mTBIs was significantly and positively associated with level of CJ involvement in all four models; Digit Span (p= .016), Trails A (p= .016), Trails B (p= .020), and Flanker (p= .008).Conclusions:Performance on most measures of executive functioning was not significantly associated with CJ involvement in this large, representative sample of V/SM who served in combat. Although performance on a working memory task was significantly associated with CJ involvement, the size of the effect was small and the association was in the opposite direction as expected. Number of mTBIs was significantly associated with level of CJ involvement, indicating that sustaining multiple mTBI may be linked to greater risk of CJ involvement. These findings suggest that social and psychological factors beyond executive dysfunction may better explain the relationship between history mTBIs and CJ involvement. Some aspects of military service and veteran status, such as interdisciplinary treatment for brain injury and physical, mental, and psychosocial health needs, may be protective against previously identified risk factors for arrest (e.g., deficits in executive functioning). Contextualizing mTBI within the larger behavioral health profile of V/SM, with emphasis placed on intervention for related co-morbidities, may reduce the impact of previous arrest on wellbeing and/or reduce the risk of future CJ involvement.

24 Associations Between Positive Psychological Factors and Neurocognitive Functioning in Older Adults

Objective:Psychological wellness and strong cognitive skills are both important to successful aging. Although there are well-established relationships between psychiatric illness (e.g., depression, anxiety, PTSD) and cognitive dysfunction, few studies have focused on the relationships between positive psychological factors and neurocognitive function in older adults. Our goal was to explore associations between these two sets of measures in older adults.Participants and Methods:Participants (n=111) were part of a longitudinal study of biopsychosocial functioning in independently living older adult residents of a Continuing Care Senior Housing Community. Participants were administered a cognitive screening test (Montreal Cognitive Assessment; MoCA), a comprehensive neuropsychological battery, and a set of published self-report scales measuring positive emotional and psychological function. Neuropsychological scores were appropriately normed, and composite scores were calculated for the following domains: language (Boston Naming Test, Delis-Kaplan Executive Function System [D-KEFS] Verbal Fluency), attention/working memory (Wechsler Adult Intelligence Scale-IV [WAIS-IV] Digit Span, DKEFS Visual Scanning), learning and delayed recall (Brief Visuospatial Memory Test-Revised, Hopkins Verbal Learning Test-Revised), processing speed (WAIS-IV Coding, D-KEFS Trails Number and Letter Sequencing, D-KEFS Color-Word Interference Test Color and Word Naming), and executive function (D-KEFS Color-Word Inhibition and Inhibition/Switching, DKEFS Letter/Number Switching). Self-Report scales included the Perceived Stress Scale, Center for Epidemiological Studies in Depression Scale, Emotional Support Scale, Connor-Davidson Resilience Scale, Coping Humor and Self-Efficacy Scales, Personal Mastery Scale, Meaning in Life Scale, Self-Rated Successful Aging, Satisfaction with Life, Cognitive Failures Questionnaire, and Lifetime Orientation Test-Revised. Due to the large number of psychological functioning measures, dimension reduction was undertaken via principal component analysis, resulting in a two-factor solution. Bivariate Pearson correlations were then computed between the two factor scores and each neurocognitive variable.Results:Factor 1 consisted of variables reflecting Positive Subjective Functioning. A higher score on Factor 1 (indicating higher self-rating of successful aging, fewer perceived cognitive failures, fewer reported depressive symptoms, less perceived stress/anxiety, more perceived emotional support, more satisfaction with life, more meaningfulness in life, and more search for meaning in life) was associated with better attention/working memory (r=0.226, p=0.049) and executive function (r=0.242, p=0.035). Factor 2 consisted of variables that reflected Positive Coping Skills. A higher score on Factor 2 (indicating more happiness, higher optimism, greater resilience, higher sense of personal mastery, more use of humor as a coping strategy, and greater coping self-efficacy) was associated with better performance on tests of language (r=0.325, p=0.004), learning (r=0.313, p=0.006) and delayed recall (r=0.241, p=0.035) of visual and verbal information, and better MoCA performance (r=0.440, p&lt;0.001). Neither factor was associated with processing speed.Conclusions:Higher levels of subjective functioning and positive outlook/coping skills were associated with better neuropsychological performance. Given that late life is a time of risk for cognitive decline, future research should consider the influence of positive psychological functioning on neurocognitive outcomes and vice versa, as these relationships may have neurobiological and therapeutic implications for overall function in later life.

B - 89 The Association between Cognitive Ability and Performance Consistency on Paced Auditory Serial Addition Test (PASAT).

To evaluate the relation between cognitive abilities and intra-individual variability (IIV) on the PASAT. 205 participants (M = 19years old, SD = 1.5; 55.1% female, 60% White, 24.4% Black, 6% Asian) completed the Wechsler Adult Intelligence Scale-IV (WAIS-IV), PASAT, Animal Naming, Trail-Making Test (TMT) Parts A and B, and CNS Vital Signs. Normed scores were used for analysis. IIV on PASAT was calculated as the standard deviation around their own mean across four rates of presentation (2.4, 2.0, 1.6, and 1.2seconds). Pearson r correlations revealed PASAT total score was correlated with FSIQ [r = 0.56; p < 0.001], Animal Naming [r = 0.27; p < 0.001], CNS psychomotor speed [r = 0.27; p < 0.001], CNS cognitive flexibility [r = 0.24; p < 0.001], Trails Part B [r = 0.28; p < 0.001] and CNS executive functioning [r = 0.22; p < 0.001]. PASAT IIV was negatively correlated with FSIQ [r = -0.46; p < 0.001] and Animal Naming [r = -0.15; p = 0.034]. There were no significant associations between PASAT IIV and CNS vital signs domains or TMT performance. PASAT total score and performance variability were related to general intellectual ability. Individuals with higher IQ levels were more consistent for PASAT performance and performed better on the task. This is at odds with previous IIV research in health samples where IIV increases with global cognitive ability. Additionally, PASAT IIV was negatively related to Animal Naming performance but not other aspects of executive functioning. This unexpected finding requires further research.

B - 107 Exploratory Analysis of the Relationship between Health Anxiety (HA) and Neuropsychological Performance in a Validity Controlled Sample of Patients with Post-Acute Sequelae of COVID-19 (PASC).

Since the emergence of COVID-19, research has consistently indicated cognitive difficulties as a primary complaint after infection (Altuna et al., 2021). It is unclear to what extent these cognitive deficits may be attributable to, or exacerbated by, health anxiety (HA) (Venkataramani et al., 2022). This study explored the relationship between HA and cognition in a performance validity controlled sample of patients with PASC complaints. Participants included patients referred for a focused neuropsychological evaluation for persistent cognitive complaints after COVID infection (N = 19). Participants were excluded for Test of Memory Malingering scores below standard cutoff. The sample mean age was 43years (SD = 12.9), 57.9% were female, and 47.4% were from minority racial/ethnic groups. HA was assessed using the Short Health Anxiety Inventory (SHAI). Cognitive abilities were measured using the Wechsler Adult Intelligence Scale-IV (WAIS-IV: Processing Speed Index [PSI]; Letter-Number Sequencing [LNS]) and Trail Making Test Part-A (TMT-A). Regression analyses were conducted to assess the extent to which HA predicts cognitive performance. The SHAI main subscale significantly predicted TMT-A [β= -3.93, p < 0.01] and WAIS-IV PSI [β= -4.60, p = 0.04]. The SHAI negative consequences subscale significantly predicted TMT-A [β= -4.64, p = 0.04] and WAIS-IV LNS [β= 0.49, p = 0.048]. Findings suggest that general HA predicted PSI, while fear of negative health outcomes predicted LNS. Basic attention abilities were predicted by global HA. Future studies will benefit from evaluating the moderating effect of HA on the relationship between subjective symptom severity and cognition.

알코올 사용장애와 알츠하이머 병 환자의 인지기능 평가 차이에 관한 비교 연구

Objectives: There are a few studies on how much and which cognitive function is specifically damaged by chronic alcohol drinking. By comparing neurocognitive function test results between patients with alcohol use disorder and those with Alzheimer’s disease, we aimed to find out which neurocognitive function is damaged by chronic alcohol drinking. In addition, we investigated whether the structural changes in the brain were related to cognitive function decline.&#x0D; Methods: Korean Wechsler Adult Intelligence Scale-IV and Seoul Neuropsychological Screening Battery-II were performed among patients who were diagnosed with Alzheimer’s disease and those who were diagnosed with alcohol use disorder at the department of psychiatry in Pusan National University Yangsan Hospital from November 2008 to May 2022. Among the neurocognitive domains, intelligence quotient, memory quotient, executive intelligence quotient, auditory attention and visual attention were compared. Among those who underwent cognitive function tests, the reading results for brain CT or MRI were compared.&#x0D; Results: There was no significant difference between the two groups in visual attention (p=0.219). Meanwhile, structural changes in the brain were less in the alcohol use disorder group compared to the Alzheimer’s disease group.&#x0D; Conclusion: Chronic drinking, impaired especially, visual attention to the level of Alzheimer’s disease at a relatively early age. Additional research on cognitive function impairment in alcohol use disorders is needed, referring to the results of this study.