The scientific literature contains extensive material on the hormonal regulation of sexual behavior in mammals (rats, hamsters, guinea pigs, primates), while the questions of sexual behavior in humans are found beyond scientific journals. However, in our view, there remain several questions not included in the more or less generally accepted schemes. In particular, the literature shows that sexual attraction ‐ libido in women ‐ is formed by male sex hormones ‐ androgens; increases in blood androgen concentrations increase overall sexual behavior [3], while sexual behavior in female mammals involves estrogens. This is clearly indicated by numerous experiments in which administration of estradiol-containing capsules to females induced estrus and its associated sexual behavior. Primates (or, more precisely, higher primates), which are “sensitive” to these and other hormones [2], are located between these two extremes. At the same time, sexual behavior in male mammals is controlled by the same hormones as in male humans. On this background, the biological significance of these fine biochemical evolutionary changes, responsible for such sharp inversionary changes in the hormonal regulation of sexual behavior in women is completely unclear. And are these changes relevant? At first glance, they would appear to be so. Unlike female mammals, which demonstrate sexual behavior only during estrus (this occurs only once a year in some species), women can demonstrate sexual behavior at any time from the onset of sexual maturity to old age. We will address this and a number of other phenomena from different points of view. It is generally accepted that sexual behavior can be divided into components consisting of central and peripheral mechanisms. The central mechanism corresponds to the motivational component, while the peripheral is associated with the appearance of purely voluntary behavior: erection and ejaculation in males and adoption of the lordotic position in females. The motivational component of behavior can be regarded as an analog of libido in humans. In animals, a number of indirect indications have been obtained, such as sniffing of the genitalia [8], the degree of closeness to an individual of the opposite gender ‐ using the open field test [9] ‐ and also the latency of mounting and the postejaculatory interval (the latter two only in males) [15], etc. The differences between these methods (some need the copulation act itself, others do not) arise from the fact that the existence of sexual excitation in animals in general and its extent in particular are difficult to evaluate without the fact of sexual intercourse, as they do not have mental aspects, and animals have virtually none of the capacity for verbal contact of humans.