Adult Behavior Research Articles

Neonatal estradiol and early adversity interact to modify basolateral amygdala morphology and adult behavior in female rats.

Being raised under adverse conditions during infancy and childhood represents a significant risk factor for developing later psychopathologies and dysfunctions in emotional, affective, and cognitive abilities. Depending on the type, timing, and duration of early adversity, different consequences emerge across the sexes in both human and animal models, although our understanding of the underlying interactions between sex and early life stress (ELS) is still incomplete. In this study, we used the limited bedding (LB) paradigm, a well-described model of ELS in rat pups during the first 10 days of life, and tested whether masculinization of the female brain by neonatal injections of estradiol benzoate (EB) would recapitulate the ELS-induced vulnerability phenotype of males on morphology of the basolateral amygdala (BLA) principal neurons and pre-adolescent and adult behavior. Our results show that LB-induced morphological changes in BLA neurons of weaning female rats were eliminated by EB treatment independently of early changes in estrogen receptor (ERα) expression in this region. EB treatment synergized with LB to enhance play behavior of pre-adolescent females to levels far greater than those observed in control males. In adult offspring, LB reduced time spent in the center in males and EB tended to increase social contact time compared to normal females, but only in LB conditions. Our findings indicate that neonatal masculinization of the female brain modifies specific, but not all aspects of BLA morphology and both pre-adolescent and adult behavior that are altered by ELS.

Prenatal Stress Modulates Placental and Fetal Serotonin Levels and Determines Behavior Patterns in Offspring of Mice

Available evidence from animal studies suggests that placental serotonin plays an important role in proper fetal development and programming by altering brain circuit formation, which later translates into altered abnormal adult behaviors. Several environmental stimuli, including stress and maternal inflammation, affect placental and, hence, fetal serotonin levels and thus may disturb fetal brain development. We investigated the effect of prenatal stress of varying intensities on the formation of adaptive behaviors in mouse offspring and the role of placental serotonin in these processes. Mild prenatal stress increased placental serotonin synthesis, whereas exposure to moderate stress decreased it. Prenatal stress of varying intensities also resulted in multidirectional changes in animal behavior in progeny, consistent with changes in serotonin levels in the placenta and fetal tissues. Mice exposed to mild prenatal stress showed higher sociality and exploratory activity, whereas, after moderate stress, in contrast, they avoided contact with other individuals of their species and had reduced exploratory activity, with no effect on locomotor activity. Thus, in mice, stressors of varying intensities during the critical period of intrauterine development can affect the synthesis of serotonin by the placenta and lead to multidirectional changes in animal behavior in postnatal life.

Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.

Soil-transmitted parasitic nematodes infect over 1 billion people worldwide and are a common source of neglected disease. Strongyloides stercoralis is a potentially fatal skin-penetrating human parasite that is endemic to tropical and subtropical regions around the world. The complex life cycle of Strongyloides species is unique among human-parasitic nematodes in that it includes a single free-living generation featuring soil-dwelling, bacterivorous adults whose progeny all develop into infective larvae. The sensory behaviors that enable free-living Strongyloides adults to navigate and survive soil environments are unknown. S. stercoralis infective larvae display parasite-specific sensory-driven behaviors, including robust attraction to mammalian body heat. In contrast, the free-living model nematode Caenorhabditis elegans displays thermosensory behaviors that guide adult worms to stay within a physiologically permissive range of environmental temperatures. Do S. stercoralis and C. elegans free-living adults, which experience similar environmental stressors, display common thermal preferences? Here, we characterize the thermosensory behaviors of the free-living adults of S. stercoralis as well as those of the closely related rat parasite, Strongyloides ratti. We find that Strongyloides free-living adults are exclusively attracted to near-tropical temperatures, despite their inability to infect mammalian hosts. We further show that lifespan is shorter at higher temperatures for free-living Strongyloides adults, similar to the effect of temperature on C. elegans lifespan. However, we also find that the reproductive potential of the free-living life stage is enhanced at warmer temperatures, particularly for S. stercoralis. Together, our results reveal a novel role for thermotaxis to maximize the infectious capacity of obligate parasites and provide insight into the biological adaptations that may contribute to their endemicity in tropical climates.

Gamified Mobile Health Strategies for Promoting Physical Activity in Autistic Adults.

Physical inactivity and sedentarism among autistic adults are a growing public health concern. Focusing on the integration of behavior change theories and emphasizing the unique preference for visuospatial learning and gaming technology, we hypothesize that gamified mobile health (mHealth) applications can be effective at increasing free-living physical activity and reducing sedentary behavior in autistic adults.

Characterizing supplement use and dietary behaviors in adults with acquired brain injury

ABSTRACT Background Acquired brain injury (ABI) can result in persistent symptoms and lasting disability. Supplements are becoming more popular in patients with chronic symptoms; however, little is known about supplementation and dietary behaviors after ABI. Methods In this cross-sectional observational study, questionnaires were collected from 211 adults with ABI presenting to outpatient brain injury clinics. The temporality of 54 unique supplements and 15 dietary behaviors were surveyed. Sources of information, reasons for use, side effects, and perceived safety were obtained. Results After ABI, 55% of the participants increased supplement utilization by ≥1 supplement, resulting in 74% consuming supplements (3.8±4.1 unique supplements daily); Vitamin D, multivitamins, magnesium, and omega 3- and/or −6 were most commonly consumed. Healthcare professionals were the main source of information, as reported by 69% of the respondents. The primary reason for supplementation was following a recommendation by a healthcare professional (63%). Supplementation was widely considered safe (83%), and most participants (76%) did not experience side effects. The majority of participants (70%) did not adhere to specific dietary behaviors.

Nonlinear associations between street-level greenery quantity and quality, physical activity, and sedentary behaviour in Chinese middle-aged and older adults: A socioeconomic equity perspective

Despite studies investigating the relationships among greenery, physical activity, and sedentary behaviour, it remains unclear whether such associations are nonlinear. Scant attention has also been paid to the role of greenery from a socioeconomic equity perspective. Thus, we assessed possible nonlinear associations between street-level greenery, physical activity, and sedentary behaviour in middle-aged and older adults. We also examined whether and how street-level greenery may increase socioeconomic equity in physical activity and sedentary behaviour. Data on physical activity and sedentary behaviour were obtained from the WHO Study on Global Ageing and Adult Health in Shanghai, China. The quantity and quality of street-level greenery were assessed using segmented street-view images based on deep learning methods. The results of fitting gradient-boosting decision trees showed that street-level greenery quantity was positively related to physical activity. We observed a steep increase in physical activity at low greenery quantity and flattening out at higher quantity. Street-level greenery quality was negatively related to sedentary behaviour. While sedentary behaviour did not change significantly at low greenery quality, the decrease became steep at higher quality. The greenery association was stronger for low incomers and those in deprived neighbourhoods.

Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.

Monoamine oxidase catalyzes oxidative deamination of monoamine transmitters and plays a critical role in the pathogenesis of neuropsychiatric diseases. Monoamine oxidase is classified into type A and B (MAO-A, MAO-B) according to the substrate specificity and sensitivity to inhibitors. The isoenzymes are different proteins coded by different genes localized on the X-chromosome, but they have identical intron-exon organization, similar protein structure and enzymatic mechanism and are considered to be derived from the same ancestral gene. The isoform-specific transcription organization regulates expression and function of MAO-A in response to cellular signaling pathways and environmental factors. MAO-A shows distinct properties and functions: isoform-specified polymorphisms, localization in catecholamine neurons, expression during early embryonic stage, regulation of brain architecture development and mediation of death and survival of neuronal cells. MAO-A is more flexible to genetic and environmental changes than MAO-B. Defective MAO-A expression impairs embryonic brain development and causes adult abnormal mood and behavior, as shown by human male cases with MAO-A deletion. This paper presents the regulation of brain MAO-A expression epigenetically by interaction between genetic and environmental factors. Association of aberrant MAO-A expression and activity with aggression, asocial behaviors, depressive disorders, and neurodegenerative diseases is discussed. Novel therapeutic strategy for psychiatric diseases by intervention to the regulation of MAO-A expression and activity is proposed.

Analysis of socioeconomic and built environment factors influencing travel mode choice of older adults in Georgia

This paper explores the travel behavior of older adults in comparison to younger adults using the 2017 U.S. National Household Travel Survey Georgia Add-on. We employ a discrete mode choice model to examine how the relationships between travel outcomes and socioeconomic, trip, and built environment characteristics vary by age. Travel modes are categorized into automobile, public transit, and non-motorized modes (i.e., walking and biking). The analysis reveals significant differences in factors related to non-auto mode travel outcomes between age groups. The presence of health conditions is associated with a lower likelihood of older adults choosing non-auto modes, and this effect intensifies with age. The association between trip purposes and travel outcome also varies; home-based-other purpose trips, such as healthcare appointments or community activities, are associated with a higher probability of older adults choosing non-motorized modes compared to other trip purposes. Residential density is more of a factor for older adults' non-auto mode choices, and older adults living in non-auto mode supportive environments are more likely to maintain non-auto mode usage. The study further finds that older adults and those with health conditions live and travel in less dense, less walkable areas than their counterparts, which makes it difficult for them to have viable non-auto transportation options. To expand mobility options for older adults, planners should design programs for older adults with health conditions and provide services for those who can no longer drive or without access to automobiles. Additionally, considering built environment conditions and the varying needs of individuals based on trip purposes is recommended to satisfy the mobility needs of older adults in accordance with their lifestyles.

Feasibility and effectiveness of cardiac telerehabilitation for older adults with coronary heart disease: A pilot randomized controlled trial.

Cardiac rehabilitation is a beneficial multidisciplinary treatment of exercise promotion, patient education, risk factor management, and psychosocial counseling for people with coronary heart disease (CHD) that is underutilized due to substantial disparities in access, referral, and participation. Empirical studies suggest that cardiac telerehabilitation (CTR) have safety and efficacy comparable to traditional in-person cardiac rehabilitation, however, older adults are under-reported with effectiveness, feasibility, and usability remains unclear. The study randomized 43 older adults (84% males) to the 12-week CTR intervention or standard of care. Guided by Social Cognitive Theory, participants received individualized in-person assessment and e-coaching sessions, followed by CTR usage at home. Data were collected at baseline (T0), six-week (T1), and 12-week (T2). Participants in the CTR intervention group showed significant improvement in daily steps (T1: β=4126.58, p=0.001; T2: β=5285, p=0.01) and health-promoting lifestyle profile (T1: β=23.26, p<0.001; T2: β=12.18, p=0.008) across study endpoints. Twenty participants completed the intervention, with 40% used the website for data-uploading or experiential learning, 90% used the pedometer for tele-monitoring. Improving awareness of rehabilitation and an action focus were considered key facilitators while physical discomforts and difficulties in using the technology were described as the main barriers. The CTR is feasible, safe and effective in improving physical activity and healthy behaviors in older adults with CHD. Considering the variation in individual cardiovascular risk factors, full-scale RCT with a larger sample is needed to determine the effect of CTR on psychological symptoms, body weight and blood pressure, and quality of life.

The regulatory effect of the anterior cingulate cortex on helping behavior in juvenile social isolation model mice

Social isolation during adolescence negatively impacts the development of adult social behaviors. However, the exact link between social experiences during adolescence and social behaviors in adulthood is not fully understood. In the present study, we investigated how isolation during juvenility affects harm avoidance behavior in a mouse model of juvenile social isolation. We found that mice subjected to social isolation as juveniles display atypical harm avoidance behaviors and that neurons in the anterior cingulate cortex are involved in these abnormal behaviors. Furthermore, we discovered that the chemogenetic activation of anterior cingulate cortex pyramidal neurons can rescue impaired harm-avoidance behaviors in these mice. Our findings provide valuable insights into the potential mechanisms underlying the impact of social experiences on behavior and brain function. Understanding how social isolation during crucial developmental periods can lead to alterations in behavior opens up new avenues for exploring therapeutic interventions for neuropsychiatric disorders characterized by impaired prosocial behaviors.

Risky behaviors in Ethiopian university students and its relationship with loneliness and coping self-efficacy

Research shows that risky behavior peaks in young adulthood, endangering young adult’s mental health and making it difficult for them to grow up to be responsible members of society. As a result, this study aimed to adapt the Risk Behavior Scale into Amharic and examine the relationships between risky behaviors, loneliness, and coping self-efficacy. A cross-sectional research design was used and convenience sampling was employed to gather data from a total of 242 Ethiopian university students. Confirmatory Factor Analysis (CFA) was carried out to test the factor structures of the Risky Behaviors Scale. The CFA results validated the scale’s four-factor structures (χ2 = 435, df = 183, (p < .001), CFI = 0.94, TLI = 0.91, RMSEA = 0.08, and SRMR =0.05). This would make it possible for mental health experts to research the psychological impacts of risky behaviors (alcohol use, suicidality, drug use, and khat use) in Ethiopian young adults. The findings of hierarchical regression analysis revealed that male gender and loneliness were predictors of risky behavior. This research holds significant implications for interventions that attempt to reduce loneliness in young adults to alter their vulnerabilities to risky behaviors.

Cognition and behavior in adults with neurofibromatosis type 1

Cognition and behavior in adults with neurofibromatosis type 1

Suicidal Ideation in Adolescents and Young Adults: The Role of Defeat, Entrapment, and Depressive Symptoms—From a Systematic Review to a Tentative Theoretical Model

Suicide stands as one of the leading causes of non-accidental death among adolescents and young adults. The Integrated Motivational–Volitional Model (IMV) of suicidal behavior identifies feelings of defeat and entrapment as pivotal factors in the complex dynamics underlying suicidal behaviors. Additionally, depressive symptomatology plays a crucial role in the development of these behaviors. The aim of this work was to provide a systematic review of the scientific literature on the association of three risk factors—entrapment, defeat, and depressive symptomatology—with suicidal ideation in the adolescent and young adult population and to test a tentative theoretical model. The databases used were PubMed, Web of Science, and ProQuest. Primary studies were selected that examined the role of entrapment, defeat, and depressive symptomatology in suicidal ideation among adolescents and young adults (ages 10–35). Additionally, a model based on structural equation modeling was analyzed to assess the relationships between entrapment, defeat, and depressive symptomatology and suicidal ideation. Eleven studies met the established inclusion criteria. The results showed defeat and entrapment to be associated with depressive symptomatology and suicidal ideation, regardless of the country studied. Additionally, the model indicates that entrapment and defeat lead to depressive symptomatology, which in turn contributes to the occurrence of suicidal ideation. These findings suggest that defeat and entrapment could be universal factors in explaining suicidal behavior in adolescents and young adults. Consequently, the results of this work may contribute to the development of strategies for preventing suicidal ideation in this population.

Unveiling the chemical and behavioural ecology of Tribolium castaneum (Herbst, 1797) in wheat flour: Alterations in flour metabolic content and the role of chemical cues in modulating beetles' behaviour and regulating population growth

Tribolium castaneum (Herbst, 1797) (Coleoptera: Tenebrionidae) is a notorious secondary pest of stored grains and flours, accounting for 10–15% of global annual losses in stored products. This study first evaluated the impact of T. castaneum infestation on the nutritional parameters of stored wheat flour. Infested flour exhibited reductions in total soluble sugars, triacylglycerol levels, and unsaturated fatty acids, particularly Oleic and Linoleic acid, while secondary metabolites such as phenolics, flavonoids, and tannins were increased. Behavioural assays revealed that adult beetles were significantly more attracted towards infested flour odour due to the presence of 4,8-Dimethyldecanal (4,8-DMD), an aggregation pheromone of T. castaneum. Another key compound in infested flour, 1-Pentadecene, derived from the beetles' cuticular wax, was found to influence adult beetle behaviour. At higher concentrations, 1-Pentadecene acted as a repellent for the species. Molecular docking studies suggested that 1-Pentadecene competes with 4,8-DMD for binding to the odorant receptor TcOR1, which could potentially inhibit aggregation behaviour and reduce population growth. The docking analysis revealed that 1-Pentadecene interacts with the same binding pocket on TcOR1, sharing key amino acids (MET49, PHE69, THR72, GLN73, THR134, VAL135, TYR138, LEU154, ILE177, GLY180, ALA181, TYR286) and forming similar intermolecular bonds, such as a pi-alkyl bond, with a binding affinity (ΔG = −5.7) comparable to 4,8-DMD (ΔG = −5.8). Additionally, beetles reared in wheat flour containing higher concentrations of 1-Pentadecene exhibited lower population growth compared to those reared in flour with lower concentrations of this compound.

Predicting sedentary behavior in adults using stacked LSTM modeling

Predicting sedentary behavior in adults using stacked LSTM modeling

Prime Basking Sites and Communal Basking in the Lizard, Lacerta bilineata; High Risk for Juveniles?

Sunlight and the heat it provides are important ecological resources for reptiles especially for those species living in temperate zones that bask extensively to maximize heat uptake. Sun basking has both benefits and costs for reptiles, giving heat that provides the energy to drive physiology but basking in open patches increases risk of predation due to higher visibility. Prime basking sites are believed to increase benefits for reptiles that include, in addition to open sunlit areas, facilitate detection of predators and prey and escape to nearby refuges. However, if such sites are limited, both inter and intra-specific interference may occur and this kind of competition may impact on a reptile’s ability to access prime basking sites, and as a consequence, its capacity to thermoregulate to optimum body temperatures. This may be especially important for juveniles, for whom rapid growth is a key factor in survivorship. We studied communal basking and interaction events at prime basking sites in the European green lizard, Lacerta bilineata, in a hedgerow in western France. We compared basking behaviour of adults and juveniles with sympatric adult wall lizards Podarcis muralis using non-invasive photographic-mark-recapture. Adult L. bilineata were more evenly distributed across basking sights compared to juveniles but significant differences were only detected between males and juveniles. Juvenile L. bilineata abandoned basking sites at the approach of both adult males and females and were aggressively removed by adult male L. bilineata. We found inter-specific communal basking between both adult and juvenile L. bilineata with adult wall lizards P. muralis. Communal basking was observed between male and female L. bilineata but not between adult males or between adult female L. bilineata. Communal basking was in proportionally greater frequency in juveniles compared to adult L. bilineata.

Chlorantraniliprole mediating the survival and behavior of adults of Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) in tomato

Chlorantraniliprole mediating the survival and behavior of adults of Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae) in tomato

Dysregulation of the mTOR-FMRP pathway and synapticplasticity in an environmental model of ASD.

Autism Spectrum Disorder (ASD) is caused by genetic, epigenetic, and environmental factors. Mutations in the human FMR1 gene, encoding the Fragile X Messenger Ribonucleoprotein 1 (FMRP), cause the most common monogenic form of ASD, the Fragile X Syndrome (FXS). This study explored the interaction between the FMR1 gene and a viral-like infection as an environmental insult, focusing on the impact on core autistic-like behaviors and the mGluR1/5-mTOR pathway. Pregnant heterozygous Fmr1 mouse females were exposed to maternal immune activation (MIA), by injecting the immunostimulant Poly (I:C) at the embryonic stage 12.5, simulating viral infections. Subsequently, ASD-like behaviors were analyzed in the adult offspring, at 8-10 weeks of age. MIA exposure in wild-type mice led to ASD-like behaviors in the adult offspring. These effects were specifically confined tothe intrauterine infection, as immune activation at later stages, namely puberty (Pubertal Immune Activation, PIA) at post-natal day 35 or adulthood (Adult Immune Activation, AIA) at post-natal day 56, did not alter adult behavior. Importantly, combining the Fmr1 mutation with MIA exposure did not intensify core autistic-like behaviors, suggesting an occlusion effect. Mechanistically, MIA provided a strong activation of the mGluR1/5-mTOR pathway, leading to increased LTP and downregulation of FMRP specifically in the hippocampus. Finally, FMRP modulates mTOR activity via TSC2. These findings further strengthen the key role of the mGluR1/5-mTOR pathway in causing ASD-like core symptoms.

Positive Neuropsychological Factors Associated With Greater Engagement in Brain Health Behaviors in Older Adults.

Background: Research has examined the influence of positive psychological factors including purpose in life (PIL), need for cognition (NFC), and psychological flexibility on behaviors that support brain health (i.e., preserved cognitive functioning and brain structures). However, more research is needed to examine their predictive validity in relation to other important factors in this context including emotional distress and dementia worry. Objective: The current study included 348 older adults who completed self-report measures of PIL, NFC, psychological flexibility, emotional distress, dementia worry, and brain health behavior engagement via Qualtrics. Results: Greater PIL was associated with more engagement in all brain health behaviors while NFC was only associated with more cognitive activity, heart health monitoring, and stress management. Psychological flexibility mediated the association between PIL and engagement. Conclusion: Our findings add evidence to the incremental validity of positive neuropsychological factors on engagement in brain health behaviors. Implications for neuropsychological interventions are discussed.

Environmental enrichment attenuates maternal separation-induced excessive hoarding behavior in adult female mice

BackgroundPrevious studies have demonstrated that early life stress (ELS) impacts hoarding behavior in adult humans. This study aimed to assess the potential mitigation by environmental enrichment on hoarding behavior in rodents caused by maternal separation, thereby providing insights into therapeutic strategies for hoarding disorder. MethodsNewborn mice were randomly divided into four groups. The control group was allowed to grow naturally. The maternal separation group underwent two weeks of maternal separation. The short-term environmental enrichment group received two weeks of environmental enrichment intervention after the two weeks of maternal separation. The long-term environmental enrichment group received five weeks of environmental enrichment intervention after the two weeks of maternal separation. Hoarding behavior was assessed during adolescence and adulthood. Hippocampal tissue from adult female mice was analyzed using LC-MS/MS-based metabolomics. Spearman correlation analysis was then performed to assess the relationship between differentially expressed metabolites and hoarding behavior. ResultsEnvironmental enrichment attenuates maternal separation-induced excessive hoarding behavior in adult female mice. The untargeted metabolomics of the hippocampal region in female mice showed that long-term environmental enrichment reversed multiple differential metabolites, including Substance P, which were mainly concentrated in metabolic pathways such as cancer choline metabolism, glycolipid metabolism, and linoleic acid metabolism. ConclusionsOur findings indicate that ELS and long-term environmental enrichment have sex-dependent effects on adult hoarding behavior, potentially related to altered hippocampal metabolism. This study highlights the importance of environmental enrichment in mitigating the long-term effects of early maternal separation on hoarding behavior.