We consider a class of 6D superconformal field theories (SCFTs) which have a large N limit and a semi-classical gravity dual description. Using the quiver-like structure of 6D SCFTs we study a subsector of operators protected from large operator mixing. These operators are characterized by degrees of freedom in a one-dimensional spin chain, and the associated states are generically highly entangled. This provides a concrete realization of qubit-like states in a strongly coupled quantum field theory. Renormalization group flows triggered by deformations of 6D UV fixed points translate to specific deformations of these one-dimensional spin chains. We also present a conjectural spin chain Hamiltonian which tracks the evolution of these states as a function of renormalization group flow, and study qubit manipulation in this setting. Similar considerations hold for theories without AdS duals, such as 6D little string theories and 4D SCFTs obtained from compactification of the partial tensor branch theory on a T2.