Adrenal Myelolipoma Research Articles

Clinical, radiological and histological features of adrenal myelolipoma: review and experience with a further eight cases.

To review published reports of surgically treated adrenal myelolipomas and report experience with a further eight cases. Eight patients (three men and five women, mean age 50.7 years) with adrenal myelolipoma were treated surgically because of the tumour size, symptomatology and/or associated renal pathology. Associated medical problems included hypertension in three patients and diabetes mellitus in one but none of the tumours was endocrinologically active. Five patients were diagnosed definitively by abdominal ultrasonography, computed tomography and angiography while the other three were incidentally diagnosed during surgical intervention for ipsilateral renal cell carcinoma in one patient, hydronephrotic kidney in another and multiple renal stones in the third. On pathological examination, the masses removed were surrounded by a thin fibrous capsule and compressed cortical tissue. A cut section was bright yellow with foci of red-brown discoloration. Microscopically, the tumour consisted mainly of mature adipose tissue with scattered islands of haemopoietic cells. There was no operative mortality and no gross morbidity. The management of adrenal myelolipoma should be appropriate to each individual case. Operative intervention should be reserved for symptomatic patients or those with large 'silent' tumours that may produce life-threatening shock secondary to spontaneous haemorrhage. Small asymptomatic tumours with definite radiological findings can be followed expectantly.

Genitourinary case of the day. Giant adrenal myelolipoma.

Genitourinary case of the day. Giant adrenal myelolipoma.

Spontaneous Retroperitoneal Hemorrhage from a Giant Adrenal Myelolipoma

No AccessJournal of UrologyClinical Urology: Case Report1 Feb 1996Spontaneous Retroperitoneal Hemorrhage from a Giant Adrenal Myelolipoma Howard B. Goldman, Raymond C. Howard, and A. Lynn Patterson Howard B. GoldmanHoward B. Goldman More articles by this author , Raymond C. HowardRaymond C. Howard More articles by this author , and A. Lynn PattersonA. Lynn Patterson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66474-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Spontaneous Retroperitoneal Hemorrhage from a Giant Adrenal Myelolipoma." The Journal of Urology, 155(2), p. 639 References 1 : Hemorrhagic myelolipoma of adrenal gland after blunt trauma. Urology1991; 38: 559. Google Scholar 2 : Myelolipoma of the adrenal gland associated with contralateral renal cell carcinoma: case report and review of the literature. J. Urol.1995; 153: 129. Abstract, Google Scholar 3 : Natural history of an adrenal myelolipoma. J. Urol.1992; 147: 1089. Link, Google Scholar Department of Urology, University of Tennessee, Memphis, Tennessee.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 155Issue 2February 1996Page: 639 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Howard B. Goldman More articles by this author Raymond C. Howard More articles by this author A. Lynn Patterson More articles by this author Expand All Advertisement PDF downloadLoading ...

Adrenal Cortical Adenoma with Extensive Fat Cell Metaplasia

This report describes a large adrenal cortical tumor with a significant component of mature adipose tissue in a 40 year old woman. No bone marrow elements were identified in multiple sections. This lesion, representing most likely an adrenal cortical adenoma with extensive fat cell metaplasia, has not been previously reported and must be differentiated from adrenal myelolipoma.

Adrenal Myelolipoma Associated with Hereditary Spherocytosis

Myelolipomas are benign tumors composed of mature fat and bone marrow elements. We report a case of adrenal myelolipoma associated with hereditary spherocytosis which was treated with splenectomy seventeen years ago. The hematopoietic stimulus of the hereditary spherocytosis might have been associated with the development of adrenal myelolipoma in the present case.

Retroperitoneal Hemorrhage Due to a Ruptured Adrenal Myelolipoma

Retroperitoneal Hemorrhage Due to a Ruptured Adrenal Myelolipoma

Combined Adrenal Myelolipoma and Pheochromocytoma

A 39-year-old woman had a 2-year history of headache and hyperhidrosis. Magnetic resonance imaging showed 2 right adrenal tumors with different intensities (fig. 1). 131Metaiodobenzylguanidine scintigraphy revealed accumulation at the ventral tumor. Serum levels of norepinephrine were increased (579 pg.1 ml., normal 94 to 322). A %-hour urine sample revealed abnormally increased levels of dopamine (9,206 pg., normal 190 to 7401, norepinephrine (250 pg., normal 26 to 1211, epinephrine (312 pg., normal 3 to 15), normetanephrine (2.25 mglml., normal 0.04 to 0.18) and vanillylmandelic acid (11.2 mglml., normal 0.7 to 7.0). Adrenocorticotropic hormone, cortisol and aldosterone were normal (less than 60 pg./ml., 5.6 to 21.3 pg ld l . and 2 to 3 ng./dl., respectively). Based on these results right adrenal myelolipoma combined with pheochmmocytorna was suspected and surgical extirpation was performed. Pathological evaluation revealed that the ventral tumor was a 47 X 45 X 40 mm. 48 gm. pheochmmocytoma and the dorsal tumor was a 43 X 34 X 30 mm. 23 gm. myelolipoma (fig. 2). Quantitative analysis of

Combined Adrenal Myelolipoma and Pheochromocytoma

Combined Adrenal Myelolipoma and Pheochromocytoma

US, CT, MR and percutaneous biopsy of adrenal myelolipomas

A group of eight asymptomatic patients with unilateral adrenal myelolipoma are reported. All lesions were discovered incidentally during US examinations for unrelated symptoms. A series of US, CT, and MR examinations showed typical findings in seven patients, and one patient presented atypical imaging, due to the predominance of myeloid tissue. A percutaneous CT-guided biopsy confirmed the definitive diagnosis in seven patients.

Clinical Spectrum of Adrenal Myelolipoma: Analysis of 8 Tumors in 7 Patients

Adrenal myelolipoma is a rare, benign, and biochemically nonfunctioning tumor. Most patients with adrenal myelolipoma are asymptomatic and the condition is discovered incidentally at autopsy. Review of the literature reveals 70 patients with surgically documented adrenal myelolipoma. We report 7 additional patients with 8 adrenal myelolipomas, of whom 5 underwent surgical removal because of tumor size, unusual imaging features or symptomatology. Of our patients 4 had symptomatic lesions requiring surgical removal, while 1 had an adrenal myelolipoma that was discovered intraoperatively. Of the remaining 2 patients 1 had a small (3 cm.) lesion discovered incidentally on excretory urography and 1 had bilateral adrenal myelolipoma discovered incidentally on computerized tomography.

Clinical Spectrum of Adrenal Myelolipoma

Clinical Spectrum of Adrenal Myelolipoma

A CASE OF ADRENAL MYELOLIPOMA ASSOCIATED WITH MASSIVE BLEEDING

Adrenal myelolipomas are usually asymptomatic. With an enlargement of the tumor lumbago and other symptoms due to pressure from enlarging tumor on the organ come out. Rupture of bleeding has been rarely reported on. Here a case of adrenal myelolipoma associated with massive retroperitoneal bleeding is presented. A 46-year-old man was sent to the hospital by ambulance because of shock state. Abdominal ultrasonography and computed tomography demonstrated the presence of retroperitoneal masses with massive hematoma in the posterior region of It-kidney. Then emergency operation was carried out. During surgery two retroperitoneal and one left adrenal tumors were recognized which were 25.0×15.0×15.0cm (3200g), 2.5×2.0×1.5cm, and 5.0×5.0×2.0cm, respectively. Histopathologically all tumors were adrenal myelolipoma and in the main tumor inner massive hemorrage was seen. Adrenal myelolipoma has been reported in about 50 cases in Japan so far. Almost of these reported cases were diagnosed incidentally by abdominal echography or CT. Inner hemorrhage case with hypovolemic shock like our case is very rare.

Myelolipoma of the Adrenal Gland Associated With Contralateral Renal Cell Carcinoma: Case Report and Review of the Literature

Adrenal myelolipoma is a rare benign hormonally inactive tumor. It is frequently detected incidentally on new imaging procedures, such as sonography and computerized tomography and, thus, the question of treatment arises. The association of myelolipomas with obesity, hypertension and malignant tumors has been described previously. We report the second case of myelolipoma associated with renal cell carcinoma. Pathogenesis, differential diagnosis and therapy are discussed.

US, CT, MR and percutaneous biopsy of adrenal myelolipomas

US, CT, MR and percutaneous biopsy of adrenal myelolipomas

Giant Adrenal Myelolipoma

The clinicopathologic features of a giant adrenal myelolipoma (diameter 16 cm, weight 900 g) are presented. The ultrasonographic and the computed tomographic appearance of adrenal myelolipoma are reviewed. Diagnostic fine-needle aspiration biopsy is recommended for avoidance of unnecessary surgical treatment.

Myelolipoma of the Adrenal Gland

We report 2 cases of large adrenal myelolipoma. Although their fatty nature was found by a CT scan and there was no endocrine activity, surgery was done because of their size and the caused discomfort.

Hemorrhagic myelolipoma of adrenal gland after blunt trauma

A case of adrenal myelolipoma is reported in a patient in whom symptoms of hematuria and flank pain developed after the patient had sustained blunt trauma. Adrenal myelolipomas are usually found incidentally at autopsy. However, the symptomatic presentation of this patient was probably caused by traumatic intratumor hemorrhage. The etiology and pathogenesis of these tumors are discussed in relation to their occasional symptomatic presentation and to their differential diagnosis.

Perinephric hemorrhage secondary to adrenal myelolipoma case report

Spontaneous perinephric hemorrhage has been described as occurring secondary to a number of primary renal abnormalities, but rarely from other causes. We describe the computed tomography (CT) and ultrasound findings of this event resulting from hemorrhage from an adrenal myelolipoma.

MR Imaging of Adrenal Myelolipomas

The magnetic resonance (MR) images in six patients with seven adrenal myelolipomas are presented. Four lesions involved the right gland, and three the left; they ranged from 3 to 12.5 cm in diameter. Magnetic resonance was able to image all lesions. Using T1-weighted sequences, three structural patterns were observed; (a) homogeneous masses with intensity equal to adjacent fat (three cases); (b) heterogeneous masses with fat intensity areas and areas similar to renal cortex (two cases); and (c) nodules quite different from fat, hypointense to the liver (two cases). On T2-weighted images, myelolipomas were slightly hypointense to fat and either hypo- or isointense to the liver. A comparison with the results of CT studies was possible in all cases, and good correlation with determination of the presence and quantity of fat density tissues within the lesions was observed. However, MR imaging did not seem to help in diagnosing adrenal myelolipoma in patients with equivocal CT findings, and needle biopsy is still needed in difficult cases.

穿刺細胞診で診断し得た副腎ｍｙｅｌｏｌｉｐｏｍａの１例

穿刺細胞診で診断し得た副腎ｍｙｅｌｏｌｉｐｏｍａの１例