The aims of this study are to analysis adoption and impacts of conservation agriculture on poverty and resilience to drought in Eastern Ethiopia. Multi-stage sampling method was employed and four districts were randomly selected from Eastern Hararghe Zone. Using cross-sectional survey data collected in 2023 from 430 households, multinomial endogenous switching regression was applied in impact evaluation. The result shows farm experience, education, climatic-shocks experience, access to climate information, access to extension, number of oxen, farm size, labor force, livestock and distance to market are determinants of conservation agriculture (CA) adoption in terms of inter-cropping, crop rotation and crop residue retention or mulch practices in its single and combination of practices. Poverty was evaluated based on cost-of-basic-need and resilience to drought is in its index. Accordingly, the food poverty line and total consumption expenditure or total poverty line was found to be 6582.7ETB and 8620.70ETB per Adult/Equivalent per year in the study area. Results of average treatment effect on treated shows adoption is significantly reduced poverty and increased resilience to drought condition in the area. The study also shows importance role of extension service in adoption of CA practices. There is a need to encourage extension facilities and awareness to promote better adoption of CA particularly, in its combination. The combination of practices increased consumption expenditure of adopters by 73.3 percent compared to non-adopters, given its significant impact on households’ poverty and resilience to drought in moisture stress area of eastern Ethiopia. So, it is crucial to more advances farmers and experts’ information on climate shocks and conservation agricultural practices adoption. The policymakers ought to develop and encourage farmers’ asset building plan including livestock, adult education, market linkage facilities, extension and weather related information delivery service to enhance adoption of conservation agricultural practices to combat the current and future drought.