The study focused on Cloud Computing practices among Small and Medium-Sized Enterprises (SMEs), the Contemporary trends, Possibilities, and Challenges. The objectives were to review the history behind cloud computing in relation to SMEs in Ghana, to examine factors that impact the adoption of cloud computing by SMEs in Ghana that tend to affect their performance, to analyze the impact of cloud computing migration strategy on cloud computing adoption, to evaluate the merits and demerits of cloud computing adoption, and to analyze the security involved in using cloud computing. The study employed a descriptive research design to describe the variables of interest, and information. This study found that cloud computing has a favorable impact on SMEs by reducing their operating costs, thereby increasing their margins. It also revealed that despite the many advantages of cloud computing, demerits such as security and privacy, lack of skills, expertise, and resources, and limited flexibility and control contribute to the low rate of cloud service adoption in Ghana. It is recommended that cloud services must be developed to integrate seamlessly with the existing Information Technology (IT) systems prevalent in the SME industry, and cloud service providers provide adequate migration training for SMEs as part of the adoption process. It also emphasizes the need for future cloud technology research to review new cloud services and practices that SMEs can adopt to gain a competitive advantage in the market.
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