Administration Of Gold Salts Research Articles

Generalized Chrysiasis Improved with Pulsed Dye Laser

Chrysiasis is the phenomenon of bluish to slategray skin pigmentation induced by prolonged treatment with gold salts. The most common etiology is the administration of gold salts to patients with rheumatoid arthritis. Although parental gold salt administration is now uncommon because of the availability of biologic agents and disease-modifying antirheumatic drugs, chrysiasis may still be seen because this condition can develop decades after discontinuing gold salts. Discoloration can persist for a lifetime.

Antitumor antibodies and immunoglobulin class and subclass levels in Corynebacterium parvum-treated mice.

Changes in immunoglobulin class and subclass levels and the development of antitumor antibodies were assessed in normal and tumor-bearing mice challenged with Corynebacterium parvum. C. parvum administration resulted in a marked increase in certain immunoglobulin levels, especially Ig G2b, and in the development of antibodies reacting with syngeneic and allogeneic tumor cells. The serologic changes induced by C. parvum were dependent on the dose and route of administration; preliminary studies suggested that they may have been largly independent of T-cell function. These changes were suppressed by the administration of gold salts, which also inhibited the antitumor effect of C. parvum.

The nephrotic syndrome as a complication of gold therapy.

AbstractA patient with rheumatoid arthritis developed a reversible nephrotic syndrome secondary to gold therapy. A review of the world literature revealed 18 other case reports of the nephrotic syndrome apparently associated with the administration of gold salts. Renal tissue was available for study in only 8 of these; membranous glomeruionephritis was the predominant lesion. This rare complication of gold therapy appears to have a good prognosis. Two thirds of the patients have recovered from the nephrotic syndrome.

The effect of 2,3-dithiopropanol on gold toxicity in rats.

Abstract The toxicity from gold salts injected into albino rats is described. BAL had no protective effect when injected several days after toxic doses of gold were administered. When injected simultaneously with the administration of toxic doses of gold sufficient to be lethal to rats, BAL prevented important toxicity; the animals lived in apparently good health. These observations indicate that BAL is an effective antidote for gold if it is given in adequate amounts sufficiently early after the administration of gold salts. These results further suggest that to have maximal effect in human beings who have toxicity from gold salts, BAL should be given as soon as signs of toxicity are observed.

The Problem of Dosage in the Administration of Gold Salts for Rheumatoid Arthritis

The Problem of Dosage in the Administration of Gold Salts for Rheumatoid Arthritis