Malaria was a significant global health challenge, particularly affecting children under five years of age in endemic regions. This review examined the effectiveness of various preventive measures against malaria in children, including insecticide-treated nets (ITNs), preventive chemotherapy, intermittent preventive treatment in infants (IPTi), and health education interventions. A systematic literature search across multiple databases to collate and analyze studies assessing the impact of these preventive measures on malaria outcomes in children was carried out and utilized in compiling this review paper. The findings indicated that a combination of these strategies can substantially reduce malaria incidence and associated morbidity in children. ITNs have been shown to provide a protective barrier against mosquito bites, while IPTi effectively reduces malaria cases in infants through timely administration of antimalarial drugs during immunization visits. Additionally, health education interventions have proven effective in increasing awareness and promoting the use of preventive measures among caregivers and communities. Despite the progress made, challenges such as insecticide resistance and access to healthcare services remain critical barriers to achieving optimal malaria control. Keywords: Malaria prevention, Insecticide-treated nets (ITNs), Preventive chemotherapy, Intermittent preventive treatment (IPT), Childhood malaria