AbstractThe extensive use of multidirectional composite laminates requires to understand the delamination behavior at interfaces between plies with different fiber orientations. In this study, double cantilever beam testing was performed to investigate the mode I interlaminar fracture of carbon fiber reinforced polymer laminates with different central interfaces (0//0, 0//+45 and +45//−45). X‐ray microtomography revealed the curved crack front shape that was incorporated to calculate fracture toughness. The fracture toughness varies with the crack length in a typical delamination resistance curve, which can be quantified by an empirical equation. Incorporation of variable fracture toughness into a cohesive zone model can better predict the delamination fracture of the laminate, compared to constant toughness. It was found that the delamination mechanism is independent of central interfaces. However, compared to unidirectional laminates, multidirectional laminates are less resistant to crack initiation, but more resistant to propagation with higher toughness and shorter fiber bridging zone.Highlights Mode I interlaminar fracture of CFRP laminates with different central interfaces was investigated experimentally and numerically. Curved crack front shape was incorporated to calculate fracture toughness. Incorporation of variable fracture toughness into a cohesive zone model can better predict the delamination fracture of the laminate. Multidirectional laminates are less resistant to crack initiation but more resistant to propagation with higher toughness and shorter fiber bridging zone.