The energy possibility of the transition of free bubbles A to adherent bubbles M, or the A → M (TAM) transition, is calculated on substrates with different wetting abilities: extremely hydrophilic (Φ), extremely hydrophobic (Γ), and with incomplete wetting ability (Hx), where x is the substrate surface fraction covered by a monolayer of collector molecules). Calculations of TAM for bubbles with a diameter (de) of 2 mm to 20 nm on Φ, Γ, and Hx substrates showed that the change in specific energy (ΔG/V) in a bubble in the case of TAM depends on the value of de, substrate wetting ability, and surface area of its contact with the bubble. According to the results of studies, high capillary pressure (Pc) in nanobubbles M promotes their instantaneous spreading over the substrate. Herewith, Pc decreases considerably. The adhesion and spreading processes occur as a single process, irreversibly, one-way, and fast, because they are not complicated by counterprocesses. Upon a decrease in equatorial diameter de and wetting ability of the substrate, the decrease in G/V reaches several million J/m3. The actual simultaneity of the processes of bubble adhesion and spreading is illustrated by microphotographs of larger bubbles with a luminescent apolar reagent eliminating the effect of wetting hysteresis that is easily overcome in nanobubbles in the case of high Pc values.