Adenoma Of Minor Salivary Glands Research Articles

Pleomorphic Adenoma of Palate: A Case Report

INTRODUCTION Pleomorphic adenoma is one of the most common benign salivary gland tumor affecting the major salivary glands mainly parotid gland of approx. 80% but infrequently the minor salivary glands of palate of approx. 7%. Salivary gland tumors are rare accounting only 2–3% of tumors occurring in head and neck region. The majority of minor salivary gland tumors are malignant in nature. The most common sites for minor salivary gland where pleomorphic adenoma arises are the palates followed by lips and cheek. This case report presents a case of pleomorphic adenoma of minor salivary gland of palate treated successfully by wide surgical excision with 1 cm healthy margin with uninvolved anatomical barrier under general anesthesia.

Pleomorphic Adenoma of the Soft Palate: The Pillars of Reconstruction

Salivary gland tumour contributed less than 5% of all head and neck tumours. The most common benign tumour of the salivary glands is pleomorphic adenoma. Palate is the common subsite in the oral cavity affected by this tumour. We herein discussed a case of pleomorphic adenoma of the soft palate and the reconstruction dilemma. A 41-year-old male presented with soft palate swelling, which gradually increasing in size in the last 5 years. Intraoral examination revealed well defined, 3x3 cm circumscribed mass at the soft palate, not crossing the midline, encroaching the hard palate, but spared the retromolar trigone and gingivobuccal sulcus. Incisional biopsy performed and histopathological examination showed features of pleomorphic adenoma. He underwent wide local excision of the pleomorphic adenoma with reconstruction using buccal myomucosal flap. Buccal flap was an excellent choice due to its proximity with good recovery. Pleomorphic adenoma of minor salivary gland of the soft palate was managed by complete excision but reconstructing the palatal defect was the cornerstone of managing this tumour. The aim was to preserve functionality and to prevent velopharyngeal insufficiency. Buccal myomucosal flap offered both advantageous, in addition to its proximity to the defect with negligible donor morbidity.

Management of pleomorphic adenoma of minor salivary gland- A case report

The neoplasms of the salivary glands account about 2% of head and neck tumours and among them, the Pleomorphic adenoma is the most common form. It is benign epithelial lesion of salivary gland origin, showing histopathological variation. The pleomorphic adenoma shows female predilection. The common sites for the intraoral Pleomorphic Adenoma are palate, buccal mucosa and lips. The article presents a case of Pleomorphic Adenoma of minor salivary gland of palate, which was treated successfully by surgical excision.

Pleomorphic adenoma of minor salivary glands: Review of the literature

Background: According to the WHO, pleomorphic adenoma (PA) is a benign tumor with variable cytomorphological and architectural manifestations. Objective: Our objective is to review the literature of all reported cases of PA of minor salivary glands from 2003 to 2023. Age, sex, location, clinical, radiographic and histological characteristics, prognosis and treatment options will be reviewed. Materials and methods: A literature search was carried out in PUBMED with the keywords: pleomorphic adenoma and minor salivary glands. Results: Twenty-four case reports in English were included after applying the inclusion criteria. The average age of appearance of the PA was 33.7 years. The male-female ratio was 19:11. The most frequent location was the hard palate (29%). 16.66% of cases presented pain. 27 of the 30 cases (90%) were encapsulated and 28 cases were treated by surgical resection (93.33%). Conclusion: PA constitutes up to two thirds of all salivary gland neoplasms. It presents a predilection for the female sex, it most commonly appears in the parotid gland and in the palate, the treatment of choice is surgical excision and its prognosis is good.

Pleomorphic Adenoma of Minor Salivary Gland

Minor salivary gland tumors represent about 10-15% of salivary gland tumors. The most frequently seen histological type are pleomorphic adenomas, which are usually located at the hard palate. Clinical and pathological features of 7 cases are reviewed.

Perplexity in Diagnosing Pleomorphic Adenoma of Minor Salivary Gland with Plasmacytoid Cell

Perplexity in Diagnosing Pleomorphic Adenoma of Minor Salivary Gland with Plasmacytoid Cell

HMGA2-WIF1 Rearrangements Characterize a Distinctive Subset of Salivary Pleomorphic Adenomas With Prominent Trabecular (Canalicular Adenoma-like) Morphology.

Most of salivary gland neoplasms (benign and malignant) are characterized by recurrent gene fusions. Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal rearrangements involving PLAG1 mapped to 8q12 and HMGA2 mapped to 12q13-15 in most cases. Multiple fusion partners have been identified including CTNNB1, FGFR1, LIFR, CHCHD7 and TCEA for PLAG1 fusions and NFIB, WIF1 and FHIT for HMGA2 fusions. To date, no data exist on the morphology of the few reported HMGA2-WIF1-rearranged PAs. We present 28 major salivary gland adenomas displaying distinctive trabecular and canalicular morphology associated with recurrent genotype. Patients were 15 females and 13 males aged 43 to 87 (median: 65). All tumors originated from the parotid. Their size range was 1 to 4 cm (mean: 2.3). Histologically, all tumors showed elongated or columnar cells arranged into bilayered to multilayered communicating and branching strands and trabeculae in a manner similar to canalicular adenoma of minor salivary glands or trabecular myoepithelioma with variable solid confluent intercalated duct-like areas. Fifteen tumors were exclusively canalicular/trabecular while 13 had intermingled or well-demarcated conventional (chondromyxoid) PA component comprising 5 to >50% of the tumor. The monomorphic areas expressed uniformly CK7 (28/28), vimentin (21/21), S100 (24/24), SOX10 (16/17) and variably p63 (8/21) and mammaglobin (6/16) but were negative with p40 (0/24), smooth muscle actin (0/24) and MUC4 (0/16). Targeted RNA sequencing revealed HMGA2 fusions in 14/16 (87%) assessable cases. Fusion partner was WIF1 (12), RPSAP52 (1) and HELB (1). Separate testing of the 2 components in 1 hybrid tumor showed same HMGA2/WIF1 fusion. HMGA2 immunohistochemistry was homogeneously positive in all cases including the 2 fusion-negative cases. A control cohort of 12 genuine canalicular adenomas revealed no HMGA2 fusions (0/4) and lacked HMGA2 immunoreactivity (0/12). This study highlights a distinctive variant in the spectrum of PA characterized by prominent trabecular and canalicular adenoma-like morphology. Our data confirm that canalicular adenomas in major salivary glands (either monomorphic or part of hybrid tumors) are distinct from canalicular adenoma of minor salivary glands. Their uniform genotype irrespective of presence or absence of a conventional PA component argues for classifying those tumors lacking a conventional PA component as "monomorphic variants of PA" rather than canalicular/basal cell adenomas, intercalated duct adenoma, trabecular myoepithelioma or true hybrid tumors.

Canalicular adenoma of minor salivary gland: Report of a case and a brief review of the literature

We refer a case of a canalicular adenoma of minor salivary gland, located at the submucosal region of the upper lip. The patient’s clinical state was thoroughly studied, along with the histopathological findings. Numerous histogenesis theories and the appropriate tumor treatment are mentioned, being always in accordance with the relative literature. Canalicular adenoma of minor salivary gland is a rare oral mucosa lesion. The differential diagnosis among many oral swellings is interesting. The surgical excision is the treatment of choice. The histological examination confirms the clinical diagnosis.

Pleomorphic Adenoma of Hard Palate: A Case Series

ABSTRACT Introduction Pleomorphic adenoma of minor salivary glands of the hard palate is a rare benign tumor that has elements of both epithelial and mesenchymal tissues. It usually presents as slow-growing painless submucosal mass on the hard palate. Diagnosis rests on clinical features and tissue examination with radiological investigations helping in surgical planning. Aim and objective To add to the literature few more cases of this relatively rare condition and discuss its clinical presentation and management. Case description Here, we present a case series of three patients who presented with a mass over the hard palate that was subsequently diagnosed as pleomorphic adenoma and discuss the treatment of the same. Conclusion Treatment of choice is wide local excision with removal of periosteum or bone if involved. Recurrence rate is low. How to cite this article Gupta SR, Thorawade VP, Khan MHMS. Pleomorphic Adenoma of Hard Palate: A Case Series. Int J Otorhinolaryngol Clin 2020;12(1):11–13.

Systematic Review of Clinical and Radiographic Signs of Pediatric Pleomorphic Adenoma of Minor Salivary Glands

To examine the clinical signs, radiographical features, and demographics of pediatric pleomorphic adenoma (PA) in the minor salivary glands. Several databases were searched for relevant studies. The included studies were assessed for methodological quality. Demographic, clinical, and radiographic data were collected. Sixteen of 3,121 articles met the inclusion criteria (17 lesions). The mean age was 9.7 ± 3.9 years and majority were females n = 10 (59%). It is commonly presented as asymptomatic swelling n = 16 (94.1%), in the hard palate 13 (76.5%). Radiographically, most were well-defined n = 15 (93.7%) and 8 (47%) caused erosion or displacement of surrounding tissues. The small size and asymptomatic nature of pediatric PA can render these lesions undiagnosed. On rare occurrences, PA can show calcifications, MRI, or CT enhancement. MRI is the best imaging modality to depict soft tissue content but not subtle erosion of adjacent bony structures. The dentist can be the first to detect PA in the mouth of a child. Augmenting clinical examination with radiographic examination is paramount to ensure adequate diagnosis of PA, examine effects on surrounding bone, and maintain close follow-up as watchful waiting is not safe in this population.

Pleomorphic adenoma in buccal mucosa: A case report

Introduction: Pleomorphic adenoma is one of the most common salivary gland neoplasms, with the parotid gland being the most affected site and a lower incidence in the minor salivary glands. This article reports an unusual clinical case of pleomorphic adenoma of minor salivary gland, located in the buccal mucosa and presents its treatment.

Pleomorphic Adenoma of the Cheek. Case Report with Review

Pleomorphic adenoma (PA), also called benign mixed tumor, is the most common tumor of the salivary glands. About 70 % of these tumors occur in the parotid gland and an uncommon site are the minor salivary glands. The most common sites of PA of the minor salivary glands are the palate followed by lips and cheek. Other rare reported sites include the fauces, floor of the mouth, tongue, tonsil, pharynx, retromolar area and nasal cavity. Here we report a case of pleomorphic adenoma of minor salivary glands of the cheek in a 22-year-old male. The mass was removed by wide local excision with adequate margins, and the patient was followed for 1-year post operatively with no recurrence.

Usual pathology at an unusual site - pleomorphic adenoma of parapharyngeal space: a rare case report

<p class="abstract">The parapharyngeal space is an inverted triangular pyramid. Parapharyngeal space masses account for 0.5% of all head and neck tumours and the majority is benign. Minor salivary gland tumour is a rare entity. A 75 years old female presented with a mass left side soft palate, per operatively mass of size about 6×3 cm was deeply extending to left parapharyngeal space and excised through transoral approach which came out to be pleomorphic adenoma of minor salivary gland on histopathological examination. Although external approach should be preferred due to important structure in vicinity but transoral approach can be used in selective cases.</p>

Pleomorphic Adenoma of minor Salivary Gland arising from Thyroglossal Duct: Uncommon Presentation

Pleomorphic Adenoma of minor Salivary Gland arising from Thyroglossal Duct: Uncommon Presentation

Pleomorphic adenoma of minor salivary gland in the floor of mouth

Pleomorphic adenoma of minor salivary gland in the floor of mouth

Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

Pleomorphic Adenoma of Minor Salivary Glands: a Case Report

Pleomorphic adenoma in the cheek a rare finding

Pleomorphic adenoma, also known as the benign mixed tumor is the most common tumor of salivary gland origin, accounting for about 60% of all salivary tumors. Up to 80% of tumors which occur in the parotid gland only, 10% in the submandibular glands, and the rest in the minor salivary glands. The pleomorphic adenoma comprises of the majority of both major and minor salivary gland tumors accounting for 3%–10% of neoplasms of head and neck region. The most common sites of pleomorphic adenoma of the minor salivary glands are the palate, followed by lips and then cheeks. These minor salivary gland pleomorphic adenomas require diagnosis based on clinical features and incisional biopsy should be avoided. These are managed by wide surgical excision. The recurrence of this tumor is a well-known factor, and inadequate initial surgical procedure is the most common cause of recurrence. Carcinoma arising from pleomorphic adenoma accounts for about 3% of salivary tumors. We are reporting a case of pleomorphic adenoma of minor salivary glands around the upper right buccal vestibule in a 36-year-old female.

An unusual presentation of mixed tumor of salivary gland

Pleomorphic adenoma is one of the salivary gland tumors affecting both major and minor salivary glands. Parotid gland is the most commonly affected of the major group, and hard palate is the most common site of the minor salivary glands affected. Pleomorphic adenoma is a benign mixed tumor of the salivary glands that has elements of both epithelial and mesenchymal tissues. We report a case of pleomorphic adenoma of minor salivary glands in the soft palate. Incisional biopsy revealed features of pleomorphic adenoma.

Primary Pleomorphic Adenoma of Minor Salivary Gland in the Parapharyngeal Space

ABSTRACTParapharyngeal space (PPS) lesions account for only 0.5% head and neck tumors and the majority of the minor salivary gland tumors are malignant. We report a case of pleomorphic adenoma of minor salivary gland in PPS as this is of a very rare occurrence. High index of suspicion and an adequate clearance of the tumor with a cuff of surrounding dispensable normal tissues are the key to successful treatment of such tumors.How to cite this articleRay CS, Joshi A. Primary Pleomorphic Adenoma of Minor Salivary Gland in the Parapharyngeal Space. Int J Otorhinolaryngol Clin 2016;8(3):125-127.

Pleomorphic Adenoma of Minor Salivary Gland in Buccal Mucosa: an Uncommon Finding

AbstractSalivary gland tumors account for less than 3% of the head and neck tumors. Among various salivary gland tumors, pleomorphic adenoma is most common and accounts for 60- 70% of the benign tumors of salivary glands. However, the involvement of minor salivary glands of buccal mucosa is extremely uncommon and reported to be 4% only. Salivary glands may present with a diverse range of lesions presenting a challenge to even the most experienced clinician. We report two rare cases of pleomorphic adenoma of minor salivary glands of buccal mucosa in a 45 year old female and 70 years old male respectively. It includes clinical features, diagnosis and treatment of the tumor.