We study continuous bounded cohomology of totally disconnected locally compact groups with coefficients in a non-Archimedean valued field K \mathbb {K} . To capture the features of classical amenability that induce the vanishing of bounded cohomology with real coefficients, we start by introducing the notion of normed K \mathbb {K} -amenability, of which we prove an algebraic characterization. It implies that normed K \mathbb {K} -amenable groups are locally elliptic, and it relates an invariant, the norm of a K \mathbb {K} -amenable group, to the order of its discrete finite p p -subquotients, where p p is the characteristic of the residue field of K \mathbb {K} . Moreover, we prove a characterization of discrete normed K \mathbb {K} -amenable groups in terms of vanishing of bounded cohomology with coefficients in K \mathbb {K} . The algebraic characterization shows that normed K \mathbb {K} -amenability is a very restrictive condition, so the bounded cohomological one suggests that there should be plenty of groups with rich bounded cohomology with trivial K \mathbb {K} coefficients. We explore this intuition by studying the injectivity and surjectivity of the comparison map, for which surprisingly general statements are available. Among these, we show that if either K \mathbb {K} has positive characteristic or its residue field has characteristic 0 0 , then the comparison map is injective in all degrees. If K \mathbb {K} is a finite extension of Q p \mathbb {Q}_p , we classify unbounded and non-trivial quasimorphisms of a group and relate them to its subgroup structure. For discrete groups, we show that suitable finiteness conditions imply that the comparison map is an isomorphism; this applies in particular to finitely presented groups in degree 2 2 . A motivation as to why the comparison map is often an isomorphism, in stark contrast with the real case, is given by moving to topological spaces. We show that over a non-Archimedean field, bounded cohomology is a cohomology theory in the sense of Eilenberg–Steenrod, except for a weaker version of the additivity axiom which is however equivalent for finite disjoint unions. In particular there exists a Mayer–Vietoris sequence, the main missing piece for computing real bounded cohomology.