Introduction: Depression is widely prevalent among the former opioid addicts in Methadone Maintenance Treatment (MMT). It is important to be aware of its severity as it plays a crucial role in methadone dosage, length of time in treatment and the relapse rate. The co-existence of depression is seen to worsen the prognosis in outcome of MMT.Objective: This study aimed to study the prevalence of the symptoms of depression among MMT clients.Method: This is a descriptive and Cross-Sectional study done in 60 MMT clients attending the out patients clinic in Tribhuwan University Teaching Hospital, Nepal. A structured proforma was constructed obtaining the data regarding age, sex, religion, occupation, marital status, literacy rate and socio-economical status. Depressive symptoms were evaluated using 21-item BDI scale.Result: Depressive symptoms were found in 63.3 % of the patients. 38.3% had mild to moderate depression, 15% had moderate to severe, and 11.7% had severe level of depressive symptoms. The depressive symptoms were most prevalent among females (90%) and age group 40-50 years. The prevalence of depressive symptoms were more in unmarried (82%), unemployed (65%), lower socio-economic class(71%) and completing only secondary level in education (73%).Conclusion: The major risk factors for depression among former opioid users were female gender, unmarried, low education level, unemployment and low socio-economic status.