To address the problems of low detection accuracy of rolling bearings under different loads and the difficulty of effectively identifying the lack of labelled data, a rolling bearing fault diagnosis method combining GADF-DFT image coding and Multi-kernel domain coordinated adaptation network is proposed. Firstly, the vibration signal is converted into a two-dimensional image using GADF coding technology, and then the GADF image is converted into the frequency domain using discrete Fourier transform to extract deeper feature information. Combined with the multi-source domain adaptive method, the public feature extraction module is used to initially achieve feature mining of the image; the MK-MMD algorithm of the domain-specific adaptive module reduces the difference in feature distribution between the source and target domains; and the final classification difference minimization module reduces the problems caused by the classification errors that may be generated by the different domain classifiers due to the fact that the data samples are located near the category boundaries. The test uses the Case Western Reserve University dataset and divides the dataset with different operating conditions as the source and target domains, and the test results show that the proposed model demonstrates its effectiveness in responding to the complex operating condition changes in rolling bearing fault detection in multiple operating condition migration tasks, good adaptability and robustness, and is able to achieve accurate fault diagnosis under different operating conditions.