This paper studies the coordinate optimization control problem of networked control systems (NCSs) with random time delay and packet dropout. A discrete-time system model of NCSs with time-delays and data packet dropout is proposed. A method of state estimation base on extra kalman filter is given. Then a gain-schedule adaptive LQG control strategy base on effective delay-estimation online is proposed. The result illustrate that the effectiveness of the proposed controller design and the satisfactory performance of the system.